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A Study to Compare the Efficacy and Safety of BMS-986489 (BMS-986012+ Nivolumab Fixed Dose Combination) in Combination With Carboplatin Plus Etoposide to That of Atezolizumab With Carboplatin Plus Etoposide as First-Line Therapy in Participants With Extensive-Stage Small Cell Lung Cancer (TIGOS).

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研究单位： [1]Bristol-Myers Squibb [2],South Korea,28644 [3],South Korea,03722 [4],South Korea,05505 [5],Spain,15706 [6],Spain,08036 [7],Spain,08041 [8]Southern Cancer Center, PC,Daphne 4058219,Alabama 4829764,United States,36526 [9]Local Institution - 0283,Hot Springs 4115412,Arkansas 4099753,United States,71913 [10]Florida Cancer Specialists - South,Fort Myers 4155995,Florida 4155751,United States,33901 [11]Mid Florida Hematology and Oncology Center,Orange City 4167055,Florida 4155751,United States,32763 [12]Florida Cancer Specialists - North,St. Petersburg 4171563,Florida 4155751,United States,33705 [13]Northwest Georgia Oncology Centers, a Service of Wellstar Cobb Hospital,Marietta 4207783,Georgia 4197000,United States,30060 [14]Illinois Cancer Care,Peoria 4905687,Illinois 4896861,United States,61615 [15]Local Institution - 0037,Minneapolis 5037649,Minnesota 5037779,United States,55407 [16]University of New Mexico Comprehensive Cancer Center,Albuquerque 5454711,New Mexico 5481136,United States,87106 [17]Duke Cancer Institute,Durham 4464368,North Carolina 4482348,United States,27710 [18]Oncology Hematology Care,Cincinnati 4508722,Ohio 5165418,United States,45242 [19]Local Institution - 0239,Cleveland 5150529,Ohio 5165418,United States,44106 [20]Sanford Cancer Center,Sioux Falls 5231851,South Dakota 5769223,United States,57104 [21]Local Institution - 0307,Knoxville 4634946,Tennessee 4662168,United States,37909 [22]SCRI Oncology Partners,Nashville 4644585,Tennessee 4662168,United States,37203 [23]Texas Oncology - Central/South Texas,Austin 4671654,Texas 4736286,United States,78705 [24]Texas Oncology - Northeast Texas,Tyler 4738214,Texas 4736286,United States,75702 [25]Oncology & Hematology Associates of Southwest Virginia, Inc.,Roanoke 4782167,Virginia 6254928,United States,24014 [26]Swedish Cancer Institute - Edmonds,Edmonds 5793427,Washington 5815135,United States,98026 [27]Swedish Medical Center,Seattle 5809844,Washington 5815135,United States,98104 [28]Local Institution - 0007,Tacoma 5812944,Washington 5815135,United States,98405 [29]Instituto Alexander Fleming,Ciudad Autónoma de Buenos Aires,Buenos Aires 3435907,Argentina,C1426ANZ [30]Hospital Italiano de Buenos Aires,ABB,Buenos Aires F.D. 3433955,Argentina,C1199ABB [31]Local Institution - 0100,Buenos Aires 3435910,Buenos Aires F.D. 3433955,Argentina,C1417DTB [32]Clinica Adventista Belgrano,CABA,Buenos Aires F.D. 3433955,Argentina,C1430EGF [33]Instituto Médico Río Cuarto,Río Cuarto 3838874,Córdoba Province 3860255,Argentina,X5800AEV [34]GenesisCare - Campbelltown,Campbelltown 2172586,New South Wales 2155400,Australia,2560 [35]Nepean Hospital,Penrith 2153471,New South Wales 2155400,Australia,2750 [36]Gallipoli Medical Research Ltd,Brisbane 2174003,Queensland 2152274,Australia,4120 [37]Grampians Health,Ballarat Central 8014922,Victoria 2145234,Australia,3350 [38]St. John of God Murdoch Hospital,Murdoch 8349091,Western Australia 2058645,Australia,6150 [39]Medizinische Universität Graz,Graz 2778067,Styria 2764581,Austria,8036 [40]Klinikum Wels-Grieskirchen GmbH,Wels 2761524,Upper Austria 2769848,Austria,4600 [41]Kepler Universitätsklinikum,Linz 2772400,Austria,4021 [42]Landeskrankenhaus Rankweil,Rankweil 2767974,Austria,6830 [43]Local Institution - 0250,Vienna 2761369,Austria,1210 [44]Cliniques universitaires Saint-Luc,Brussels 2800866,Bruxelles-Capitale, Région de,Belgium,1200 [45]UZ Gent,Ghent 2797656,Oost-Vlaanderen,Belgium,9000 [46]VITAZ,Sint-Niklaas 2786578,Oost-Vlaanderen,Belgium,B-9100 [47]Local Institution - 0180,Leuven 2792482,Vlaams-Brabant,Belgium,3000 [48]Centre Hospitalier Universitaire de Liège - Domaine Universitaire du Sart Tilman,Liège 2792413,Belgium,4000 [49]Local Institution - 0166,Fortaleza 3399415,Ceará 3402362,Brazil,60135-237 [50]Local Institution - 0165,Porto Alegre 3452925,Rio Grande do Sul 3451133,Brazil,90035-903 [51]Local Institution - 0169,Porto Alegre 3452925,Rio Grande do Sul 3451133,Brazil,90610-000 [52]Local Institution - 0170,Santa Cruz do Sul 3450269,Rio Grande do Sul 3451133,Brazil,96830-180 [53]Local Institution - 0163,Itajaí 3460845,Santa Catarina 3450387,Brazil,88301-220 [54]Local Institution - 0178,Barretos 3470451,São Paulo 3448433,Brazil,14784400 [55]Local Institution - 0111,São Paulo 3448439,São Paulo 3448433,Brazil,01509-010 [56]Local Institution - 0289,Edmonton 5946768,Alberta 5883102,Canada,T6G 1Z2 [57]CIUSSS- saguenay-Lac-Saint-Jean,Chicoutimi 5921225,Quebec 6115047,Canada,G7H 5H6 [58]IUCPQ,Québec 6325494,Quebec 6115047,Canada,G1V 4G5 [59]Centre intégré de santé et de services sociaux du Bas Saint-Laurent- Hôpital régional de Rimouski,Rimouski 6354895,Quebec 6115047,Canada,G5L 5T1 [60]Oncocentro Apys,Viña del Mar 3868121,Región de Valparaíso 3868621,Chile,2520598 [61]Orlandi Oncologia,Santiago 3871336,Santiago Metropolitan 3873544,Chile,0 [62]Fundacion Arturo Lopez Perez (FALP),Santiago 3871336,Santiago Metropolitan 3873544,Chile,7500921 [63]Pontificia Universidad Catolica de Chile,Santiago 3871336,Santiago Metropolitan 3873544,Chile,8330032 [64]Bradfordhill,Santiago 3871336,Santiago Metropolitan 3873544,Chile,8420383 [65]Beijing Cancer hospital,Beijing 1816670,Beijing Municipality 2038349,China,100142 [66]Beijing Chest Hospital,Capital Medical University,Beijing 1816670,Beijing Municipality 2038349,China,101149 [67]Chongqing University Cancer Hospital,Chongqing 1814906,Chongqing Municipality 1814905,China,400030 [68]Fujian Cancer Hospital,Fuzhou 1810821,Fujian 1811017,China,350014 [69]Local Institution - 0212,Xiamen 1790645,Fujian 1811017,China,361003 [70]Cancer Hospital of Shantou University Medical College,Shantou 1795940,Guangdong 1809935,China,515000 [71]Local Institution - 0227,Harbin 2037013,Heilongjiang 2036965,China,150081 [72]Local Institution - 0208,Wuhan 1791247,Hubei 1806949,China,430030 [73]Hubei Cancer Hospital,Wuhan 1791247,Hubei 1806949,China,430079 [74]Local Institution - 0216,Changsha 1815577,Hunan 1806691,China,410013 [75]The First Affiliated Hospital of Nanchang University,Nanchang 1800163,Jiangxi 1806222,China,330006 [76]Jilin Province Tumor Hospital,Changchun 2038180,Jilin 2036500,China,132000 [77]Local Institution - 0235,Shenyang 2034937,Liaoning 2036115,China,110042 [78]Xi''an International Medical Center Hospital,Xi''an 1790630,Shaanxi 1796480,China,710126 [79]Shandong Cancer Hospital,Jinan 1805753,Shandong 1796328,China,250117 [80]Local Institution - 0206,Shanghai 1796236,Shanghai Municipality 1796231,China,200030 [81]Zhongshan Hospital,Fudan University,Shanghai 1796236,Shanghai Municipality 1796231,China,200032 [82]Sichuan Cancer hospital,Chengdu 1815286,Sichuan 1794299,China,610041 [83]Tianjin Medical University Cancer Institute & Hospital,Tianjin 1792947,Tianjin Municipality 1792943,China,300060 [84]Sir Run Run Shaw Hospital of Zhejiang University School of Medicine,Hangzhou 1808926,Zhejiang 1784764,China,310016 [85]Zhejiang Cancer Hospital,Hangzhou 1808926,Zhejiang 1784764,China,310022 [86]Taizhou Hospital of Zhejiang Province,Linhai 1803422,Zhejiang 1784764,China,317000 [87]Shanghai East Hospital,Shanghai 1796236,China,200120 [88]Masarykuv onkologicky ustav,Brno 3078610,Brno-město,Czechia,656 53 [89]Nemocnice AGEL Ostrava - Vitkovice a.s.,Ostrava 3068799,Ostrava Město,Czechia,703 00 [90]Fakultni Thomayerova nemocnice,Prague 3067696,Praha 4,Czechia,14059 [91]Fakultni nemocnice Olomouc,Olomouc 3069011,Czechia,779 00 [92]Hôpital Arnaud de Villeneuve - CHU Montpellier,Montpellier 2992166,Hérault,France,34090 [93]Chu Grenoble Alpes,La Tronche 3006131,Isère,France,38700 [94]CHU Lille - Institut Coeur Poumon,Lille 2998324,Nord,France,59037 [95]L Hopital Nord Ouest,Gleizé 3015823,Rhône,France,69400 [96]Centre Hospitalier Lyon Sud,Pierre-Bénite 2987314,Rhône,France,69310 [97]Centre Hospitalier Intercommunal de Créteil,Créteil 3022530,Val-de-Marne,France,94010 [98]Gustave Roussy,Villejuif 2968705,Val-de-Marne,France,94800 [99]Assistance Publique Hôpitaux de Marseille - Hôpital Nord,Marseille 2995469,France,13915 [100]Institut Curie,Paris 2988507,France,75248 [101]Centre Hospitalier de Cornouaille Quimper - Concarneau,Quimper 2984701,France,29000 [102]Krankenhaus Nordwest GmbH,Frankfurt am Main 2925533,Hesse 2905330,Germany,60488 [103]Pius Hospital Oldenburg,Oldenburg 2857458,Lower Saxony 2862926,Germany,26121 [104]Klinikum Köln-Merheim,Cologne 2886242,North Rhine-Westphalia 2861876,Germany,51109 [105]Krankenhaus Martha-Maria Halle-Dölau,Halle 2911522,Saxony-Anhalt 2842565,Germany,06120 [106]Zentralklinik Bad Berka,Bad Berka 2953548,Thuringia 2822542,Germany,99437 [107]Local Institution - 0263,Berlin 2950159,Germany,14165 [108]Asklepios Klinik Gauting GmbH,Gauting 2922230,Germany,82131 [109]LungenClinic Grosshansdorf,Großhansdorf 2915556,Germany,22927 [110]Thoraxklinik-Heidelberg gGmbH,Heidelberg 2907911,Germany,69126 [111]Robert Bosch Krankenhaus GmbH,Stuttgart 2825297,Germany,70736 [112]Errikos Dunant Hospital Center,Athens 264371,Attikí,Greece,115 26 [113]"Thoracic General Hospital of Athens ""I Sotiria"",Athens 264371,Attikí,Greece,115 27" [114]"""Theagenio"" Cancer Hospital of Thessaloniki,Thessaloniki 734077,Kentrikí Makedonía,Greece,540 07" [115]European Interbalkan Medical Center,Thessaloniki 734077,Thessaloníki,Greece,570 01 [116]University General Hospital of Larissa,Larissa 258576,Thessalía,Greece,41110 [117]Local Institution - 0274,Bengaluru 1277333,Karnataka 1267701,India,560017 [118]Local Institution - 0278,New Delhi 1261481,National Capital Territory of Delhi 1273293,India,110029 [119]Local Institution - 0271,Madurai 1264521,Tamil Nadu 1255053,India,625107 [120]Local Institution - 0277,Varanasi 1253405,Uttar Pradesh 1253626,India,221005 [121]Local Institution - 0273,Kolkata 1275004,West Bengal 1252881,India,700094 [122]Istituto Nazionale Tumori IRCCS Fondazione Pascale,Napoli 9031661,Campania 3181042,Italy,80131 [123]Fondazione IRCCS Istituto Nazionale dei Tumori,Milan 3173435,Lombardy 3174618,Italy,20133 [124]Istituto Nazionale Tumori Regina Elena,Rome 3169070,Roma,Italy,00144 [125]AO Santa Maria della Misericordia,Perugia 3171180,Umbria 3165048,Italy,06132 [126]Casa di Cura Dott. Pederzoli,Peschiera del Garda 3171152,Verona,Italy,37019 [127]IRCCS Azienda Ospedaliero-Universitaria di Bologna, Policlinico di Sant''Orsola,Bologna 3181928,Italy,40138 [128]Istituto Europeo di Oncologia IRCCS,Milan 6951411,Italy,20141 [129]National Hospital Organization Shikoku Cancer Center,Matsuyama 1926099,Ehime 1864226,Japan,791-0280 [130]Kurume University Hospital,Kurume 1858088,Fukuoka 1863958,Japan,830-0011 [131]Hokkaido University Hospital,Sapporo 2128295,Hokkaido 2130037,Japan,0608648 [132]Kobe City Medical Center General Hospital,Kobe 1859171,Hyōgo 1862047,Japan,650-0047 [133]Kanazawa University Hospital,Kanazawa 1860243,Ishikawa-ken 1861387,Japan,920-8641 [134]Kanagawa Cardiovascular and Respiratory Center,Yokohama 1848354,Kanagawa 1860291,Japan,236-0051 [135]Sendai Kousei Hospital,Sendai 2111149,Miyagi 2111888,Japan,9810914 [136]Nara Medical University Hospital,Kashihara 1859953,Nara 1855608,Japan,634-8522 [137]Kurashiki Central Hospital,Kurashiki 1858311,Okayama-ken 1854381,Japan,710-8602 [138]Kansai Medical University Hospital,Hirakata 1862540,Osaka 1853904,Japan,573-1191 [139]Kindai University Hospital- Osakasayama Campus,Ōsaka-sayama 11612568,Osaka 1853904,Japan,589-8511 [140]Osaka Medical and Pharmaceutical University Hospital,Takatsuki 1850910,Osaka 1853904,Japan,569-8686 [141]Saitama Medical University International Medical Center,Hidaka 6822161,Saitama 1853226,Japan,350-1298 [142]Saitama Prefectural Cancer Center,Ina-machi,Saitama 1853226,Japan,362-0806 [143]Hamamatsu University Hospital,Hamamatsu 1863289,Shizuoka 1851715,Japan,431-3192 [144]Nippon Medical School Hospital,Bunkyo-ku,Tokyo 1850144,Japan,1138603 [145]The Cancer Institute Hospital of JFCR,Koto,Tokyo 1850144,Japan,135-8550 [146]Fukushima Medical University,Fukushima 2112923,Japan,960-1295 [147]Local Institution - 0310,Kuala Lumpur 1735161,Kuala Lumpur 1733046,Malaysia,50586 [148]Local Institution - 0312,Kuala Lumpur 1735161,Kuala Lumpur 1733046,Malaysia,50603 [149]Local Institution - 0311,Kuching 1735634,Sarawak 1733038,Malaysia,93586 [150]Local Institution - 0148,Pachuca 3522210,Hidalgo 3527115,Mexico,42000 [151]Local Institution - 0146,Guadalajara 4005539,Jalisco 4004156,Mexico,44630 [152]Local Institution - 0147,Monterrey 3995465,Nuevo León 3522542,Mexico,66460 [153]Local Institution - 0145,Puebla City 3521081,Mexico,72424 [154]Amsterdam UMC, locatie VUmc,Amsterdam 2759794,North Holland 2749879,Netherlands,1081 HV [155]Ziekenhuis Rijnstate,Arnhem 2759661,Netherlands,6815 AD [156]University Medical Center Groningen,Groningen 2755251,Netherlands,9713 GZ [157]Przychodnia Lekarska KOMED,Konin 3095321,Greater Poland Voivodeship 3337498,Poland,62-500 [158]Pratia Poznań,Poznan 3088171,Greater Poland Voivodeship 3337498,Poland,60-192 [159]Szpital Specjalistyczny w Prabutach Spolka z o.o.,Prabuty 3088161,Pomeranian Voivodeship 3337496,Poland,82-550 [160]Centrum Onkologii im. Prof. Franciszka Lukaszczyka,Bydgoszcz 3102014,Poland,85796 [161]Instytut Centrum Zdrowia Matki Polki,Lodz 3093133,Łódź Voivodeship 3337493,Poland,93-338 [162]SC Memorial Healthcare International SRL,Bucharest 683506,București 683504,Romania,013812 [163]Institutul Oncologic Bucuresti,Bucharest 683506,București 683504,Romania,022328 [164]SC Radiotherapy Center Cluj SRL,Florești,Cluj 681291,Romania,407280 [165]"Centrul de Oncologie ""Sfântul Nectarie"",Craiova 680332,Dolj 679134,Romania,200542" [166]Institutul Oncologic Cluj,Cluj-Napoca 681290,Romania,400015 [167]S.C. Centrul de Oncologie Euroclinic S.R.L.,Iași 675810,Romania,700106 [168]Institutul Regional de Oncologie,Iași 675810,Romania,700483 [169]Seoul National University Bundang Hospital,Seongnam 6876792,Kyǒnggi-do,South Korea,13620 [170]Ajou University Hospital,Suwon 1835553,Kyǒnggi-do,South Korea,16499 [171]Keimyung University Dongsan Hospital,Daegu 1835329,Taegu-Kwangyǒkshi,South Korea,42601 [172]Hospital Universitario de Jaen,Jaén 2516395,Jaén,Spain,23007 [173]Hospital Universitario Ramón y Cajal,Madrid 3117735,Madrid, Comunidad de,Spain,28034 [174]Hospital Universitario 12 de Octubre,Madrid 3117735,Madrid, Comunidad de,Spain,28041 [175]Hospital Universitario Puerta de Hierro Majadahonda,Majadahonda 3117667,Madrid, Comunidad de,Spain,28222 [176]Hospital General Universitario de Valencia,Valencia 2509954,Valenciana, Comunitat,Spain,46014 [177]Local Institution - 0299,Seville 2510911,Spain,41009 [178]Hospital Universitario Virgen Del Rocio,Seville 2510911,Spain,41013 [179]Kantonsspital Graubünden,Chur 2661169,Switzerland,7000 [180]Kantonsspital Winterthur,Winterthur 2657970,Switzerland,8401 [181]UniversitätsSpital Zürich,Zurich 2657896,Switzerland,8091 [182]Local Institution - 0158,Çiğli 320257,İzmir 311044,Turkey (Türkiye),35620 [183]Local Institution - 0154,Adana 325363,Turkey (Türkiye),01370 [184]Local Institution - 0157,Ankara 323786,Turkey (Türkiye),06010 [185]Local Institution - 0177,Ankara 323786,Turkey (Türkiye),06280 [186]Local Institution - 0153,Istanbul 745044,Turkey (Türkiye),34732 [187]Local Institution - 0197,London 2643743,London, City of,United Kingdom,SE1 9RT [188]James Cook University Hospital,Central Middlesbrough,Middlesbrough,United Kingdom,TS4 3BW [189]Aberdeen Royal Infirmary,Aberdeen 2657832,United Kingdom,AB9 2ZB [190]Local Institution - 0108,Leicester 2644668,United Kingdom,LE1 5WW [191]The Christie NHS Foundation Trust,Manchester 2643123,United Kingdom,M20 4BX [192]The Clatterbridge Cancer Centre,Metropolitan Borough of Wirral 7733088,United Kingdom,CH63 4JY

关键词： BMS-986489 BMS-986012 Extensive-Stage Small Cell Lung Cancer Etoposide Carboplatin Nivolumab TIGOS fucGM1 SCLC ES-SCLC atigotatug

研究目的：

The Purpose of the Study is to Compare the Efficacy and Safety of BMS-986489 (Anti-fucosyl-GM1+ Nivolumab Fixed Dose Combination) in Combination with Carboplatin plus Etoposide to that of Atezolizumab with Carboplatin plus Etoposide as First-Line Therapy in Participants with Extensive-Stage Small Cell Lung Cancer.