研究单位：[1]Peking University First Hospital[2]The Pepple's Hospital of Chizhou,Chizhou,Anhui,China,247099[3]Dongzhimen Hospital Beijing University of Chinese Medicine,Beijing,Beijing,China,100007[4]Guang'anmen Hospital China Academy of Chinese Medical Sciences,Beijing,Beijing,China,100055[5]Xiyuan Hospital of CACMS（China Academy of Chinese Medical Sciences,Beijing,Beijing,China,100091[6]Peking Union Medical College Hospital,Beijing,Beijing,China,100730[7]The First Affiliated Hospital of Chongqing Medical University,Chongqing,Chongqing,China[8]Peking University Shenzhen Hospital,Shenzhen,Guangdong,China,518034[9]The Fourth Hospital of Hebei Medical University (Hebei Tumor Hospital),Shijia Zhuang,Hebei,China,050011[10]The First Affiliated Hospital Of Zhengzhou University,Zhengzhou,Henan,China,450052[11]Henan Provincial People's Hospital,Zhengzhou,Henan,China,463599[12]Jiangyin People's Hospital,Jiangyin,Jiangsu,China,214400[13]Jiangsu Province Hospital,Nanjing,Jiangsu,China,210029[14]The People's Hospital of Wuxi,Wuxi,Jiangsu,China,214023[15]The First Affiliated Hospital Of Shandong First Medical University,Jinan,Shandong,China,250013[16]The Pepple's Hospital of Liaocheng,Liaocheng,Shandong,China,252000[17]Xijing Hospital, Fourth Military Medical University,Xi'an,Shanxi,China,710032[18]Sichuan Provincial People's Hospital,Chendu,Sichuan,China,610072[19]The First Affiliated Hospital of Chengdu Medical College,Chendu,Sichuan,China,610500[20]Chengdu Seventh People's Hospital,Chengdu,Sichuan,China,610041[21]Sichuan Cancer Hospital,Chengdu,Sichuan,China,610042
Intraoperative hypothermia is common in patients having major surgery and the compliance with intraoperative temperature monitoring and management remains poor. Studies suggest that intraoperative hypothermia is an important risk factor of postoperative delirium, which is associated with worse early and long-term outcomes. Furthermore, perioperative hypothermia increases stress responses and provokes immune suppression, which might promote cancer recurrence and metastasis. In a recent trial, targeted temperature management reduced intraoperative hypothermia and emergence delirium. There was also a trend of reduced postoperative delirium, although not statistically significant. This trial is designed to test the hypothesis that intraoperative targeted temperature management may reduce postoperative delirium and improves progression-free survival in older patients recovering from major cancer surgery.
