研究单位:[1]Hansoh BioMedical R&D Company[2]Anhui Provincial Cancer Hospital,Hefei,Anhui,China,230031[3]Fujian Provincial Tumor Hospital,Fujian,Fujian,China,350014[4]The 900th Hospital of the Joint Service Support Force of the Chinese People's Liberation Army,Fuzhou,Fujian,China,350014[5]Guangdong Provincial People's Hospital,Guangzhou,Guangdong,China,510000[6]Harbin Medical University Cancer Hospital,Harbin,Heilongjiang,China,1540000[7]Tumour Hospital of Anyang city,Anyang,Henan,China,455000[8]The First Affiliated Hospital of Henan University of Science & Technology,Luoyang,Henan,China,471003[9]Nanyang Central Hospital,Nanyang,Henan,China,422000[10]The First Affiliated Hospital of Xinxiang Medical University,Xinxiang,Henan,China,453100[11]Henan Cancer Hospital,Zhengzhou,Henan,China,450003[12]The First Affiliated Hospital of Zhengzhou University,Zhengzhou,Henan,China,450052[13]Tongji Hospital, affiliated with Tongji Medical College, Huazhong University of Science and Technology,Wuhan,Hubei,China,430030[14]Hubei Cancer Hospital,Wuhan,Hubei,China,430079[15]Nantong Tumor Hospital,Nantong,Jiangsu,China,226300[16]Jiangyin People's Hospital,Wuxi,Jiangsu,China,214400[17]Jiangxi Provincial Tumor Hospital,Nanchang,Jiangxi,China,330038[18]Liaoning Cancer Hospital,Shenyang,Liaoning,China,110000[19]The First Hospital of China Medical University,Shenyang,Liaoning,China,110002[20]Affiliated Hospital of Jining Medical University,Jining,Shandong,China,272000[21]Sichuan Cancer Hospital&Institude, Sichuan Cancer Center,Affiliate Cancer Hospital Of University Of Electronic Science and Technology of China,Chengdu,Sichuan,China,610041[22]The Affiliated Cancer Hospital of Xinjiang Medical University,Ürümqi,Xinjiang,China,830011
HS-20093 is a humanized IgG1 antibody-drug conjugate (ADC) which specifically binds to B7-H3, a target wildly expressed on solid tumor cells. The objectives of this study are to investigate the anti-tumor activity, safety, pharmacokinetics and immunogenicity of HS-20093 in Chinese advanced esophageal carcinoma and other solid tumor patients.