研究单位：[1]Hansoh BioMedical R&D Company[2]Anhui Cancer Hospital,Hefei,Anhui,China[3]Beijing Cancer Hospital,Beijing,Beijing,China[4]Beijing Tongren Hospital, CMU,Beijing,Beijing,China[5]Fujian Cancer Hospital,Fuzhou,Fujian,China[6]Sun Yai-Sen Memorial Hospital Sun Yai-Sen University,Guangzhou,Guangdong,China[7]Sun Yat-Sen University Cancer Center,Guangzhou,Guangdong,China[8]The Fifth Affiliated Hospital Sun Yat-Sen University,Zhuhai,Guangdong,China[9]Guangxi Medical University Cancer Hospital,Nanning,Guangxi,China[10]Harbin Medical University Cancer Hospital,Harbin,Heilongjiang,China[11]Henan Cancer Hospital,Zhengzhou,Henan,China[12]The First Affiliated Hospital of Zhengzhou University,Zhengzhou,Henan,China[13]Tongji Hospital affiliated to Tongji Medical College of Huazhong University of Science & Technology,Wuhan,Hubei,China[14]Hunan Cancer Hospital,Changsha,Hunan,China[15]The Second XIANGYA Hospital Of Central South University,Changsha,Hunan,China[16]The Second Hospital of Dalian Medical University,Dalian,Liaoning,China[17]Liaoning Cancer Hospital,Shenyang,Liaoning,China[18]Cancer Hospital of Shandong First Medical University,Jinan,Shandong,China[19]Shanghai East Hospital,Shanghai,Shanghai,China,200120[20]Shanghai Ninth People's Hospital, Shanghai JiaoTong University School of Medicine,Shanghai,Shanghai,China[21]The first Affiliated Hospital of Xi'an Jiaotong University,Xi'an,Shanxi,China[22]Sichuan Cancer Hospital,Chengdu,Sichuan,China[23]West China Hospital of Sichuan University,Chengdu,Sichuan,China[24]Tianjin Cancer Hospital,Tianjin,Tianjin,China[25]Cancer hospital of Xinjiang medical University,Xinjiang,Xinjiang,China[26]Zhejiang Cancer Hospital,Hangzhou,Zhejiang,China
研究目的：
HS-20093 is a fully humanized IgG1 antibody-drug conjugate (ADC) which specifically binds to B7-H3, a target wildly expressed on solid tumor cells. This is a phase 2, open-label, multi-center study to evaluate the efficacy, safety, pharmacokinetics (PK) and immunogenicity of HS-20093 as a monotherapy in patients with head and neck squamous cell carcinoma and other solid tumors.
