研究单位：[1]Akeso[2]Cancer hospital, Chinese academy of medical sciences and Peking union medical college[3]Henan Cancer Hospital[4]The first affiliated hospital of bengbu medical college,Bengbu,Anhui,China,233099[5]Anhui provincial hospital,Hefei,Anhui,China,230001[6]Anhui provincial cancer hospital,Hefei,Anhui,China,230088[7]The first affiliated hospital of wannan medical college,Wuhu,Anhui,China,241001[8]Cancer hospital, Chinese academy of medical sciences and Peking union medical college,Beijing,Beijing,China,100021[9]The Fifth Medical Center of the Chinese People's Liberation Army General Hospital,Beijing,Beijing,China,100039[10]Beijing Cancer Hospital,Beijing,Beijing,China,100142[11]Beijing Chest hospital,Beijing,Beijing,China,101149[12]Chongqing University Cancer Hospital,Chongqing,Chongqing,China,400030[13]Fujian cancer hospital,Fuzhou,Fujian,China,350014[14]Zhangzhou municipal hospital of fujian province,Zhangzhou,Fujian,China,363099[15]Gansu provincial cancer hospital,Lanzhou,Gansu,China,730050[16]The First Affiliated Hospital of Sun Yat-sen University,Guangzhou,Guangdong,China,510080[17]Affiliated cancer hospital and institute of guangzhou medical university,Guangzhou,Guangdong,China,510095[18]Nanfang hospital,Guangzhou,Guangdong,China,510515[19]Cancer hospital Chinses academy of medical sciences， shenzhen center,Shenzhen,Guangdong,China,518172[20]Hainan cancer hospital,Haikou,Hainan,China,570312[21]Affiliated hospital of Hebei university,Baoding,Hebei,China,050031[22]The second people's hospital of Hengshui,Hengshui,Hebei,China,053099[23]The Second Hospital of HeBei Medical University,Shijiazhuang,Hebei,China,050004[24]The Fourth Hospital of Hebei Medical University,Shijiazhuang,Hebei,China,050011[25]Tangshang people's hospital,Tangshan,Hebei,China,063001[26]Harbin medical university cancer hospital,Harbin,Heilongjiang,China,150081[27]Jiamusi Tuberculosis Prevention and Control Hospital (Jiamusi Cancer Hospital),Jiamusi,Heilongjiang,China,154007[28]The first hospital of Qiqihar,Qiqihar,Heilongjiang,China,161005[29]The First Affiliated Hospital of Henan University of Science and Technology,Luoyang,Henan,China,450052[30]Nanyang central hospital,Nanyang,Henan,China,473005[31]The First Affiliated Hospital of Xinxiang Medical College,Xinxiang,Henan,China,45310[32]Henan Cancer Hospital,Zhengzhou,Henan,China,450003[33]The First Affiliated Hospital of Zhengzhou University,Zhengzhou,Henan,China,450052[34]Renmin Hospital of Wuhan University,Wuhan,Hubei,China,430060[35]Hubei Cancer Hospital,Wuhan,Hubei,China,430079[36]Xiangya Hospital of Central South University,Changsha,Hunan,China,410008[37]The Second Xiangya Hospital, Central South University,Changsha,Hunan,China,410012[38]Hunan Cancer Hospital,Changsha,Hunan,China,410013[39]The First Affiliated Hospital of Soochow University,Suzhou,Jiangsu,China,215006[40]The affiliated hospital of xuzhou medical university,Xuzhou,Jiangsu,China,221799[41]First Affiliated Hospital of Gannan medical college,Ganzhou,Jiangxi,China,341000[42]First Affiliated Hospital of Nanchang University,Nanchang,Jiangxi,China,330006[43]The first hospital of Jilin Universit,Changchun,Jilin,China,130061[44]Tonghua Central Hospital,Tonghua,Jilin,China,134099[45]The First Hospital of China medical University,Shenyang,Liaoning,China,110002[46]Liaoning cancer hospital,Shenyang,Liaoning,China,110801[47]General hospital of ningxia medical university,Yinchuan,Ningxia,China,750003[48]Qinghai university affiliated hospital,Xining,Qinghai,China,810012[49]Binzhou medical university hospital,Binzhou,Shandong,China,256603[50]Shandong Cancer Hospital,Jinan,Shandong,China,250117[51]The Affiliated Hospital of Qingdao University,Qingdao,Shandong,China,266000[52]Weifang NO.2 people's Hospital,Weifang,Shandong,China,261041[53]Zhongshan Hospital, Fudan university,Shanghai,Shanghai,China,200032[54]Changzhi people's hospital,Changzhi,Shanxi,China,046099[55]Shanxi Cancer hospital,Taiyuan,Shanxi,China,030013[56]The First Affiliated Hospital of Xi'an Jiaotong University,Xi'an,Shanxi,China,710061[57]Sichuan Cancer Hospital,Chengdu,Sichuan,China,610042[58]Mianyang central hospital,Mianyang,Sichuan,China,621099[59]The Second People's Hospital of Yibin City,Yibin,Sichuan,China,644000[60]Tianjin Medical University Cancer Institute & Hospital,Tianjin,Tianjin,China,300060[61]Tianjin Chest Hospital,Tianjin,Tianjin,China,300222[62]Xinjiang Medical University Cancer Hospital,Urumqi,Xinjiang,China,830000[63]Yunnan Cancer Hospital /the Third Affiliated Hospital of Kunming Medical University,Kunming,Yunnan,China,650118[64]The First Affiliated Hospital, Zhejiang University School of Medicine (FAHZU),Hangzhou,Zhejiang,China,310003[65]Zhejiang Cancer Hospital,Hangzhou,Zhejiang,China,310005
研究目的：
This is a randomized, double-blind, phase III clinical study to compare the efficacy and safety of AK104 combined chemotherapy versus Tislelizumab combined chemotherapy in first-line treatment of Locally advanced or metastatic NSCLC with PD-L1 TPS < 1%.
