A Study Evaluating Sotorasib Platinum Doublet Combination Versus Pembrolizumab Platinum Doublet Combination as a Front-Line Therapy in Participants With Stage IV or Advanced Stage IIIB/C Nonsquamous Non-Small Cell Lung Cancers (CodeBreaK 202)
研究单位：[1]Amgen[2]University of Illinois Chicago,Chicago,Illinois,United States,60612[3]Norton Cancer Institute - Brownsboro,Louisville,Kentucky,United States,40241[4]University of New Mexico Cancer Center,Albuquerque,New Mexico,United States,87131[5]Memorial Sloan Kettering Cancer Center,New York,New York,United States,10065[6]Duke University,Durham,North Carolina,United States,27710[7]University of Pittsburgh Medical Center,Pittsburgh,Pennsylvania,United States,15232[8]University of Tennessee Medical Center Knoxville,Knoxville,Tennessee,United States,37920[9]Hospital Britanico de Buenos Aires,Caba,Buenos Aires,Argentina,C1280AEB[10]Instituto Alexander Fleming,Capital Federal,Buenos Aires,Argentina,C1426ANZ[11]Instituto Argentino de Diagnostico y Tratamiento IADT,Ciudad Autónoma de Buenos Aires,Buenos Aires,Argentina,C1012AAR[12]Hospital Italiano de La Plata,La Plata,Buenos Aires,Argentina,B1900AUR[13]Fundacion Ars Medica,San Salvador de Jujuy,Jujuy,Argentina,4600[14]Clinica Viedma,Viedma,Río Negro,Argentina,8500[15]Sanatorio Parque SA,Rosario,Santa Fe,Argentina,2000[16]Centro Oncologico Korben,Buenos Aires,Argentina,1426[17]Fundacion Centro Oncológico Riojano Integral para la Investigación y Prevención del Cáncer,La Rioja,Argentina,F5300COE[18]Centro de Diagnostico Investigacion y Tratamiento,Salta,Argentina,4400[19]Campbelltown Hospital,Campbelltown,New South Wales,Australia,2560[20]Concord Repatriation General Hospital,Concord,New South Wales,Australia,2139[21]GenesisCare -North Shore Oncology,St Leonards,New South Wales,Australia,2065[22]Calvary Mater Newcastle Hospital,Waratah,New South Wales,Australia,2298[23]Toowoomba Hospital,Toowoomba,Queensland,Australia,4350[24]Princess Alexandra Hospital,Woolloongabba,Queensland,Australia,4102[25]Cancer Research South Australia,Adelaide,South Australia,Australia,5000[26]Peter MacCallum Cancer Centre,Melbourne,Victoria,Australia,3000[27]The Alfred Hospital,Melbourne,Victoria,Australia,3004[28]Medizinische Universitaet Graz,Graz,Austria,8036[29]Klinikum Klagenfurt am Woerthersee,Klagenfurt,Austria,9020[30]Universitaetsklinikum Krems,Krems,Austria,3500[31]Landeskrankenhaus Salzburg,Salzburg,Austria,5020[32]Klinikum Wels - Grieskirchen GmbH,Wels,Austria,4600[33]Chirec - Delta Ziekenhuis,Auderghem,Belgium,1160[34]Algemeen Ziekenhuis Maria Middelares,Gent,Belgium,9000[35]Universitair Ziekenhuis Leuven - Campus Gasthuisberg,Leuven,Belgium,3000[36]Centre Hospitalier Regional de la Citadelle,Liège,Belgium,4000[37]Algemeen Ziekenhuis Sint-Maarten,Mechelen,Belgium,2800[38]Hospital Sirio Libanes,Brasilia,Distrito Federal,Brazil,70200-730[39]Centro de Tratamento Oncologico - Cto,Belem,Pará,Brazil,66053-000[40]Instituto de Medicina Integral Professor Fernando Figueira - Imip,Recife,Pernambuco,Brazil,50070-550[41]Hospital Sao Lucas da Pontificia Universidade Catolica do Rio Grande do Sul,Porto Alegre,Rio Grande Do Sul,Brazil,90610-000[42]Centro de pesquisa em oncologia Hospital Ana Nery,Santa Cruz do Sul,Rio Grande Do Sul,Brazil,96835-090[43]Catarina Pesquisa Clinica,Itajaí,Santa Catarina,Brazil,88301-220[44]Fundacao Pio 12 Hospital de Amor de Barretos,Barretos,São Paulo,Brazil,14784-400[45]Santa Casa de Misericordia de Santos - Iscms,Santos,São Paulo,Brazil,11075-900[46]Beneficencia Portuguesa de Sao Paulo - Bp,Sao Paulo,São Paulo,Brazil,01323-900[47]Fundacao Antonio Prudente,Sao Paulo,São Paulo,Brazil,01509-900[48]Oncoclinicas Rio de Janeiro S A,Rio de Janeiro,Brazil,22250-905[49]Instituto de Ensino e Pesquisa Sao Lucas Iep Sao Lucas,São Paulo,Brazil,01236-030[50]Instituto do Cancer do Estado de Sao Paulo Octavio Frias de Oliveira Icesp,São Paulo,Brazil,01246-000[51]Multiprofile Hospital for Active Treatment - Uni Hospital OOD,Panagyurishte,Bulgaria,4500[52]University Multiprofile Hospital for Active Treatment Sveta Marina - Pleven OOD,Pleven,Bulgaria,5800[53]Acibadem City Clinic University Multiprofile Hospital for Active Treatment Tokuda EAD,Sofia,Bulgaria,1407[54]University Multiprofile Hospital for Active Treatment Tsaritsa Yoanna - ISUL EAD,Sofia,Bulgaria,1527[55]Queen Elizabeth II, Health Sciences Centre,Halifax,Nova Scotia,Canada,B3H 1V7[56]Sunnybrook Research Institute Sunnybrook Health Sciences Centre,Toronto,Ontario,Canada,M4N 3M5[57]McGill University Health Centre Glen Site,Montreal,Quebec,Canada,H4A 3J1[58]CIUSSS - du Nord-de-lIle-de-Montreal / Hopital Sacre-Coeur de Montreal,Montreal,Quebec,Canada,H4J 1C5[59]Institut Universitaire de cardiologie et de pneumologie de Quebec,Quebec City,Quebec,Canada,G1V 4G5[60]James Lind Centro de Investigacion del Cancer,Temuco,Cautín,Chile,4800827[61]Clinica CIDO,Temuco,Cautín,Chile,4810218[62]Orlandi Oncologia,Santiago,Chile,7500713[63]Fundacion Arturo Lopez Perez,Santiago,Chile,7500836[64]Biocinetic,Santiago,Chile,8330336[65]Centro de Investigacion del Maule,Talca,Chile,346000[66]The First Affiliated Hospital of Bengbu Medical University,Bengbu,Anhui,China,233004[67]Anhui Chest Hospital,Hefei,Anhui,China,230022[68]Fujian Medical University Union Hospital,Fuzhou,Fujian,China,350109[69]Zhongshan Hospital Xiamen University,Xiamen,Fujian,China,361004[70]Guangdong Provincial Peoples Hospital,Guangzhou,Guangdong,China,510080[71]Cancer Hospital of Shantou University Medical College,Shantou,Guangdong,China,515031[72]Liuzhou Peoples Hospital,Liuzhou,Guangxi,China,545006[73]Guangxi Medical University Cancer Hospital,Nanning,Guangxi,China,530021[74]Hainan Cancer Hospital,Haikou,Hainan,China,570311[75]The First Affiliated Hospital of Henan University of Science And Technology,Luoyang,Henan,China,471003[76]Tongji Hospital Tongji Medical College Of Hust,Wuhan,Hubei,China,430030[77]Xiangyang Central Hospital,Xiangyang,Hubei,China,441021[78]The Second Xiangya Hospital of Central South University,Changsha,Hunan,China,410011[79]Nanjing Drum Tower Hospital,Nanjing,Jiangsu,China,210008[80]Jiangxi Cancer Hospital,Nanchang,Jiangxi,China,330029[81]The First Affiliated Hospital of Nanchang University,Nanchang,Jiangxi,China,330209[82]Linyi Peoples Hospital,Linyi,Shandong,China,276002[83]Weifang Peoples Hospital,Weifang,Shandong,China,261071[84]Sichuan Cancer Hospital,Chengdu,Sichuan,China,610041[85]West China Hospital of Sichuan University,Chengdu,Sichuan,China,611135[86]Sir Run Run Shaw Hospital Affiliated to Zhejiang University School of Medicine,Hangzhou,Zhejiang,China,310016[87]Nantong Tumor Hospital,Nantong,Zhejiang,China,226361[88]Beijing Chest Hospital, Capital Medical University,Beijing,China,101149[89]Sociedad de Oncologia y Hematologia del Cesar,Valledupar,Cesar,Colombia,200001[90]Centro de Tratamiento e Investigación sobre Cancer Luis Carlos Sarmiento Angulo Ctic,Bogotá,Cundinamarca,Colombia,110131[91]Fakultni nemocnice Brno,Brno,Czechia,625 00[92]Fakultni nemocnice Olomouc,Olomouc,Czechia,779 00[93]Fakultni nemocnice Plzen,Plzen,Czechia,305 99[94]Aarhus Universitetshospital,Aarhus N,Denmark,8200[95]Regionshospitalet Godstrup,Herning,Denmark,7400[96]Rigshospitalet,Kobenhavn,Denmark,2100[97]Sonderborg Sygehus,Sonderborg,Denmark,6400[98]Centre Hospitalier Régional Universitaire de Besançon, Hôpital Jean Minjoz,Besancon cedex,France,25030
The primary objective of this study is to compare progression-free survival (PFS) in participants who receive sotorasib with platinum doublet chemotherapy versus participants who receive pembrolizumab with platinum doublet chemotherapy.
