高级检索
当前位置: 首页 > 详情页

Laparoscopic Proximal Gastrectomy With Double-flap Technique Versus Laparoscopic Total Gastrectomy With Roux-en-Y Reconstruction for Proximal Early Gastric Cancer

文献详情

编号/登记号:
研究结束时间:
项目类型:
本院角色:
多中心研究:
招募状态:
研究类型:
研究单位: [1]Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University [2]First Hospital of China Medical University [3]Tianjin Medical University Cancer Institute and Hospital [4]Liaoning Tumor Hospital & Institute [5]Sichuan Provincial People's Hospital [6]Third Affiliated Hospital, Sun Yat-Sen University [7]Qilu Hospital of Shandong University [8]First Affiliated Hospital of Kunming Medical University [9]First Affiliated Hospital of Guangxi Medical University [10]Zunyi Medical College [11]Sichuan Cancer Hospital and Research Institute [12]Gansu Provincial Hospital [13]Shandong Provincial Hospital Affiliated to Shandong First Medical University [14]The First Affiliated Hospital of Zhengzhou University [15]Qinghai Province Cancer Hospital [16]LanZhou University

关键词: laparoscopy minimally invasive surgical procedures stomach neoplasm Gastrectomy Reflux Esophagitis

研究目的:
Proximal early gastric cancer can choose radical total gastrectomy or proximal gastrectomy. But if use simple esophagogastric anastomosis for proximal gastrectomy, the incidence of postoperative reflux esophagitis is up to 62%, which seriously affects the quality of life, and the short-term outcome is poorer than the total gastrectomy. If the incidence of postoperative reflux esophagitis can be reduced, proximal gastrectomy would be the treatment choice for proximal early gastric cancer, which may more improve both quality of life and nutritional status than total gastrectomy. Double-flap technique is a new surgical procedure for the reconstruction between esophagus and remnant stomach, which was started to be applied to digestive tract reconstruction in patients with proximal early gastric cancer in 2016. It can reduce the occurrence of reflux oesophagitis. At present, the studies for double-flap technique in China and other countries are mostly retrospective studies, and there are short of large-scale prospective studies and evidence of evidence-based medicine. The applicant has initiated a phase II, single center, single arm study and the results suggested that the laparoscopic proximal gastrectomy with double-flap reconstruction technique was safe and effective for treating proximal early gastric cancer. To further validate the short and long-term outcomes of this procedure, a multicentre, open label, prospective, superiority and randomised controlled clinical trial was set up to compare laparoscopic proximal gastrectomy with double-flap technique with laparoscopic total gastrectomy with Roux-en-Y reconstruction for proximal early gastric cancer. It include 216 patients with proximal early gastric cancer. The primary outcome is the proportion of patients who develop reflux esophagitis within 12 months after surgery. The short and long-term oncological outcomes are also explored. This trial can provide high-grade evidence of evidence-based medicine for double-flap technique's clinical applications .

资源点击量:46425 今日访问量:0 总访问量:3323 更新日期:2024-11-01 建议使用谷歌、火狐浏览器 常见问题

版权所有©2020 四川省肿瘤医院 技术支持:重庆聚合科技有限公司 地址:成都市人民南路四段55号