Study of Sacituzumab Govitecan-hziy Versus Treatment of Physician's Choice in Patients With Previously Untreated Locally Advanced Inoperable or Metastatic Triple-Negative Breast Cancer
研究单位：[1]Gilead Sciences[2]Texas Oncology-Denison,Denison,Texas,United States,75020[3]The Center for Cancer & Blood Disorders - Magnolia,Fort Worth,Texas,United States,76104[4]Oncology Consultants,1631 North Loop West,Houston,Texas,United States,77008[5]Oncology Consultants,925 Gessner,Houston,Texas,United States,77024[6]Oncology Consultants,Houston,Texas,United States,77030[7]Mays Cancer Center,San Antonio,Texas,United States,78229[8]The Center for Cancer & Blood Disorders - Magnolia,920 Santa Fe Drive,Weatherford,Texas,United States,76086[9]Virginia Oncology Associates,744 N. Battlefield Blvd,Chesapeake,Virginia,United States,23320[10]Virginia Cancer Specialists, PC,7501 Right Flank Road,Mechanicsville,Virginia,United States,23116[11]Virginia Oncology Associates,1051 Loftis Blvd Suite 100,Newport News,Virginia,United States,23606[12]Virginia Oncology Associates,Norfolk,Virginia,United States,23502[13]Virginia Cancer Specialists, PC,210 Medical Park Boulevard,Petersburg,Virginia,United States,23805[14]Virginia Cancer Specialists, PC,1401 Johnston-Willis Drive,Richmond,Virginia,United States,23235[15]Virginia Cancer Specialists, PC,Richmond,Virginia,United States,23298[16]Virginia Oncology Associates,1950 Glenn Mitchell Drive,Virginia Beach,Virginia,United States,23456[17]Swedish Cancer Institute-First Hill,21632 Highway 99,Edmonds,Washington,United States,98026[18]Swedish Cancer Institute-First Hill,751 NE Blakely Drive,Issaquah,Washington,United States,98029[19]Swedish Cancer Institute-First Hill,Seattle,Washington,United States,98104[20]Swedish Cancer Institute-First Hill,747 Broadway,Seattle,Washington,United States,98122[21]Northwest Cancer Specialists, P.C,210 SE 136th Avenue,Vancouver,Washington,United States,98684[22]Hospital Británico de Buenos Aires,Buenos Aires,Argentina,1426[23]Instituto de Oncologia Angel H.Roffo,Caba,Argentina,1417[24]Fundacion CORI para la Investigacion y Prevencion del Cancer,Capital,Argentina,F5300COE[25]Instituto de Oncología de Rosario,Rosario,Argentina,2000[26]Centro para la Atencion Integral del Paciente Oncologico Centro Médico C.A.I.P.O,San Miguel de Tucumán,Argentina,4000[27]Clinica Viedma,Viedma,Argentina,8500[28]Border Medical Oncology,Albury,New South Wales,Australia,2640[29]Saint George Hospital - Australia,Kogarah,New South Wales,Australia,2217[30]Mater Hospital - North Sydney,North Sydney,New South Wales,Australia,2060[31]GenesisCare - North Shore,St Leonards,New South Wales,Australia,2065[32]Mater Misericordiae Limited and Mater Research Limited,South Brisbane,Queensland,Australia,4101[33]Princess Alexandra Hospital,Woolloongabba,Queensland,Australia,4102[34]Cancer Research SA (CRSA),Adelaide,South Australia,Australia,5000[35]Icon Cancer Centre Hobart,Hobart,Tasmania,Australia,7000[36]Monash Medical Centre,Clayton,Victoria,Australia,3168[37]Austin Hospital,Melbourne,Victoria,Australia,3084[38]Breast Cancer Research Center - Western Australia,Nedlands,Western Australia,Australia,6009[39]Universitätsklinikum Graz,Graz,Austria,8036[40]Medizinische Universität Innsbruck,Innsbruck,Austria,06020[41]Ordensklinikum Linz GmbH Barmherzige Schwestern,Linz,Austria,4010[42]Landeskrankenhaus Salzburg,Salzburg,Austria,A-5020[43]Universitätsklinikum Sankt Pölten,Sankt Poelten,Austria,3100[44]Landesklinikum Wiener Neustadt,Wiener Neustadt,Austria,2700[45]Medizinische Universität Wien,Wien,Austria,1090[46]Algemeen Ziekenhuis Klina,Brasschaat,Belgium,2930[47]Cliniques Universitaires Saint-Luc,Brussels,Belgium,1200[48]Universitair Ziekenhuis Brussel,Brussels,Belgium[49]Grand Hopital de Charleroi - Notre Dame,Charleroi,Belgium,6000[50]Universitair Ziekenhuis Gent,Gent,Belgium,9000[51]UZ Leuven,Leuven,Belgium,3000[52]Centre Hospitalier Universitaire Université Cathol,Namur,Belgium,5000[53]Hospital Araújo Jorge - Associação de Combate ao Câncer em Goiás - ACCG,Goiânia,Brazil,74605-070[54]ONCOSITE - Centro de Pesquisa Clinica em Oncologia,Ijui,Brazil,98700-000[55]Catarina Pesquisa Clínica,Itajai,Brazil,88331-10[56]Hospital Amaral Carvalho,Jau,Brazil,17210080[57]Hospital Moinhos de Vento,Porto Alegre,Brazil,90035-00[58]Hospital de Clinicas de Porto Alegre - HCPA,Porto Alegre,Brazil,90035-903[59]Hospital Sao Lucas da PUCRS,Porto Alegre,Brazil,90610001[60]Instituto Nacional de Câncer - INCA - HCIII,Rio de Janeiro,Brazil[61]Núcleo de Oncologia da Bahia,Salvador,Brazil,40170170[62]CEPHO - Centro de Estudos e PesquisaS de Hematologia e Oncologia,Santo Andre,Brazil,09060-650[63]Real e Portuguesa de Beneficéncia - Hospital Beneficéncia Portuguesa (BP) - Unidade Paulista,São Paulo,Brazil,01323-001[64]Clinica de Pesquisas e Centro de Estudos em Oncolo,São Paulo,Brazil,1317000[65]Fundação Pio XII - Hospital de Amor de Barretos,São Paulo,Brazil,14784400[66]Nucleo de Pesquisa Clinica da Rede Sao Camilo,São Paulo,Brazil,4014002[67]Cross Cancer Institute,Edmonton,Canada,T6G 1Z2[68]QEII Health Sciences Centre,Halifax,Canada,B3H 1V7[69]Grand River Regional Cancer Centre at Grand River Hospital,Kitchener,Canada,N2G 1G3[70]London Health Sciences Centre,London,Canada,N6A 5W9[71]McGill University Health Centre,Montreal,Canada,H4A 3J1[72]Jewish General Hospital,Montréal,Canada,H3T 1E2[73]Ottawa Hospital - General Campus,Ottawa,Canada,K1H 8L6[74]CISSS du Bas-Saint-Laurent - Hôpital régional de Rimouski,Rimouski,Canada,G5L 5T1[75]Sunnybrook Research Institute,Toronto,Canada,M4N 3M5[76]Mount Sinai Hospital,Toronto,Canada,M5G 1X5[77]British Columbia Cancer - Vancouver,Vancouver,Canada,V5Z 4E6[78]Oncovida - Santiago,Providencia,Chile,7510035[79]Clínica IRAM,Santiago DE CHILE,Chile[80]Centro de Oncología de Precisión,Santiago Region,Chile,8330032[81]Clínica Alemana,Santiago,Chile,7630000[82]James Lind Centro de Investigacion del Cancer,Temuco,Chile[83]Cancer Hospital Chinese Academy of Medical Sciences,Beijing,China,100021[84]Peking University People's Hospital,Beijing,China,100044[85]Beijing Cancer Hospital,Beijing,China,100142[86]The First Medical Center of Chinese PLA General Hospital,Beijing,China,100853[87]Sichuan Cancer Hospital,Chengdu,China,610041[88]West China Hospital, Sichuan University,Chengdu,China,610041[89]Chongqing University Cancer Hospital,Chongqing,China,404100[90]Deyang People's Hospital,Deyang,China,618000
研究目的：
The primary objective of this study is to compare the progression-free survival (PFS) between sacituzumab govitecan-hziy (SG) versus treatment of physician's choice (TPC) in participants with previously untreated, locally advanced, inoperable or metastatic triple-negative breast cancer whose tumors do not express programmed cell death ligand 1 (PD-L1) or in participants previously treated with anti-programmed cell death (ligand or protein) 1 (Anti-PD-(L)1) Agents in the early setting whose tumors do express PD-L1.
