Study of Dato-DXd Plus Pembrolizumab vs Pembrolizumab Alone in the First-line Treatment of Subjects With Advanced or Metastatic NSCLC Without Actionable Genomic Alterations
研究单位：[1]Daiichi Sankyo, Inc.[2]AstraZeneca[3]Merck Sharp & Dohme LLC[4]Ironwood Cancer and Research Center,Chandler,Arizona,United States,85224[5]UCLA HemOnc - Clinical Research Unit,Los Angeles,California,United States,90095[6]Compassionate Cancer Care Medical Group,Riverside,California,United States,92501[7]UCSF Helen Diller Family Comprehensive Cancer Center,San Francisco,California,United States,94158[8]Ridley-Tree Cancer Center,Santa Barbara,California,United States,93105[9]PIH Health Whittier Hospital,Whittier,California,United States,90602[10]The Oncology Institute of Hope and Innovation,Whittier,California,United States,90603[11]Uch-Mhs D/B/A Memorial Health System,Colorado Springs,Colorado,United States,80909[12]Johns Hopkins University,Baltimore,Maryland,United States,21205[13]American Oncology Partners of Maryland,Bethesda,Maryland,United States,20817[14]Dana-Farber Cancer Institute,Boston,Massachusetts,United States,02115[15]Beth Israel Deaconess Medical Center,Boston,Massachusetts,United States,02215[16]DFCI - Steward St. Elizabeth''s Medical Center,Boston,Massachusetts,United States,02215[17]Dana Farber Cancer Institute - Foxborough,Foxboro,Massachusetts,United States,02035[18]Dana Farber Cancer Institute - Milford Medical Center,Milford,Massachusetts,United States,01757[19]DFCI - South Shore Hospital,South Weymouth,Massachusetts,United States,02190[20]Dartmouth Hitchcock Medical Center,Lebanon,New Hampshire,United States,03766[21]Astera Cancer Care,East Brunswick,New Jersey,United States,08816[22]Regional Cancer Care Associates LLC,Freehold,New Jersey,United States,07728[23]Cooperman Barnabas Medical Center,New Brunswick,New Jersey,United States,08901[24]The Valley Hospital,Paramus,New Jersey,United States,07652[25]Montefiore Medical Center,Bronx,New York,United States,10461[26]Arizona Oncology NAHOA,Irving,Texas,United States,75063[27]Cancer Care Center of Brevard,Irving,Texas,United States,75063[28]Illinois Cancer Specialists,Irving,Texas,United States,75063[29]Maryland Oncology Hematology,Irving,Texas,United States,75063[30]Southern Cancer Center,Irving,Texas,United States,75063[31]Texas Oncology - Northeast Texas,Irving,Texas,United States,75063[32]Texas Oncology Gulf Coast,Irving,Texas,United States,75063[33]Texas Oncology McAllen,Irving,Texas,United States,75063[34]Woodlands Medical,Irving,Texas,United States,75063[35]University of Texas Health Science Center San Antonio,San Antonio,Texas,United States,78229[36]Utah Cancer Specialists,Salt Lake City,Utah,United States,84106[37]Providence Regional Cancer System,Lacey,Washington,United States,98503[38]Medical College of Wisconsin,Milwaukee,Wisconsin,United States,53226[39]Fundacion CENIT para la investigación en Neurociencias,Ciudad Autonoma de Buenos Aire,Argentina,1125[40]Centro de Investigación Pergamino S. A.,Pergamino,Argentina,2700[41]Instituto de Oncología de Rosario,Rosario,Argentina,S2000[42]Sanatorio Parque,Rosario,Argentina,S2001[43]Sanatorio Británico de Rosario,Rosario,Argentina,S2002[44]Clinica Viedma SA,Viedma,Argentina,8500[45]Austin Hospital,Heidelberg,Victoria,Australia,3084[46]Peninsula and South Eastern Haematology and Oncology Group,Mount Waverley,Victoria,Australia,3149[47]Chris Obrien Lifehouse,Camperdown,Australia,2050[48]The Queen Elizabeth Hospital,Woodville South,Australia,5011[49]Karl-Landsteiner Institute for Lung Research and Pulmonary Oncology c/o Klinik Floridsdorf,Vienna,Austria,1090[50]Onze-Lieve-Vrouwziekenhuis Olvz - Campus Aalst,Aalst,Belgium,9300[51]Grand Hopital de Charleroi - Hopital Saint Joseph,Charleroi,Belgium,6000[52]Az Maria Middelares - Campus Maria Middelares,Gent,Belgium,9000[53]AZ Nikolaas,Sint-Niklaas,Belgium,9100[54]Instituto de Pesquisas em Saúde - IPS,Caxias Do Sul,Brazil,95020-972[55]Hospital Erasto Gaertner,Curitiba,Brazil,81520-060[56]Oncosite - Centro de Pesquisa Clinica Oncologia,Ijui,Brazil,98700-000[57]Clínica de Neoplasias Litoral,Itajaí,Brazil,88301-220[58]UPCO - Unidade de Pesquisas Clínicas em Oncologia - Clinica Lacks,Pelotas,Brazil,96020-080[59]Santa Casa de Misericordia de Porto Alegre,Porto Alegre,Brazil,90050-170[60]Instituto Nacional de Câncer - INCA,Rio De Janeiro,Brazil,20231-050[61]Centro de Estudos e Pesquisa de Hematologia e Oncologia - CEPHO,Santo Andre,Brazil,09060-870[62]Instituto de Ensino e Pesquisas Sao Lucas,Sao Paulo,Brazil,01236-030[63]Santa Cabrini Hospital,Montréal,Canada,H1T 2M4[64]Centro de Estudios Clínicos SAGA,Santiago de Chile,Metropolitana,Chile,7500653[65]Oncovida,Santiago,Chile,7500000[66]Fundación Arturo Pérez López,Santiago,Chile,7500921[67]Orlandi Oncología,Santiago,Chile,7501010[68]Centro de Investigaciones Clinicas Vina Del Mar,Vina Del Mar,Chile,254-0488[69]Guangxi Medical University Affiliated Tumor Hospital,Nanning,Guangxi,China,530021[70]Henan Cancer Hospital,Zhengzhou,Henan,China,450008[71]Jilin Cancer Hospital,Changchun,Jilin,China,130012[72]Sichuan Cancer Hospital,Chengdu,Sichuan,China,610049[73]Peking University Peoples Hospital,Beijing,China,100044[74]Peking University Cancer Hospital,Beijing,China,100142[75]Hunan Cancer Hospital,Changsha,China,410013[76]Army Medical Center of PLA,Chongqing,China,400042[77]Affiliated Cancer Hospital and Institute of Guangzhou Medical University,Guangzhou,China,510095[78]Haikou People''s Hospital,Haikou,China,570208
This study is designed to assess the efficacy and safety of datopotamab deruxtecan (Dato-DXd) in combination with pembrolizumab versus pembrolizumab alone in participants with advanced or metastatic non-small cell lung cancer (NSCLC).
