研究单位：[1]Jiangsu Alphamab Biopharmaceuticals Co., Ltd[2]The Second Hospital Of Anhui medical University,Hefei,Anhui,China[3]Beijing Cancer Hospital,Beijing,Beijing,China[4]Beijing Friendship Hospital,Beijing,Beijing,China[5]Cancer Hospital Chinese Academy of Medical Sciences,Beijing,Beijing,China[6]Chinese PLA General Hospital,Beijing,Beijing,China[7]Peking Union Medical College,Beijing,Beijing,China[8]Peking University Third Hospital,Beijing,Beijing,China[9]Chongqing Cancer Hospital,Chongqing,Chongqing,China[10]The First Affiliated Hospital of Chongqing Medical University,Chongqing,Chongqing,China[11]The Southwest Hospital of AMU,Chongqing,Chongqing,China[12]The Third Affiliated Hospital of Army Medical University,Chongqing,Chongqing,China[13]Fujian Cancer Hospital,Fuzhou,Fujian,China[14]Fujian Medical University Union Hospital,Fuzhou,Fujian,China[15]The First Affiliated Hospital of Fujian Medical University,Fuzhou,Fujian,China[16]The First Affiliated Hospital of Xiamen University,Xiamen,Fujian,China[17]The First Hospital of Lanzhou University,Lanzhou,Gansu,China[18]Guangdong Provincial People's Hospital,Guangzhou,Guangdong,China[19]Sun Yat-sen Memorial Hospital, Sun Yat-sen University,Guangzhou,Guangdong,China[20]The First Affiliated Hospital,Sun Yat-sen University,Guangzhou,Guangdong,China[21]Affiliated Cancer Hospital of Guangxi Medical University,Nanning,Guangxi,China[22]The Affiliated Hospital of Guizhou Medical University,Guiyang,Guizhou,China[23]The Fourth Hospital of Hebei Medical University,Shijiazhuang,Hebei,China[24]Harbin Medical University Cancer Hospital,Harbin,Heilongjiang,China[25]Henan Cancer Hospital,Zhengzhou,Henan,China[26]Henan Provincial People''s Hospital,Zhengzhou,Henan,China[27]The First Affiliated Hospital of Zhengzhou University,Zhengzhou,Henan,China[28]Hubei Cancer Hospital,Wuhan,Hubei,China[29]Renmin Hospital of Wuhan University,Wuhan,Hubei,China[30]Union Hospital Tongji Medical College Huazhong University of Science And Technology,Wuhan,Hubei,China[31]Zhongnan Hospital of Wuhan University,Wuhan,Hubei,China[32]Hunan Cancer Hospital,Changsha,Hunan,China[33]Hunan Provincial People''s Hospital,Changsha,Hunan,China[34]The Second Xiangya Hospital of Central South University,Changsha,Hunan,China[35]Xiangya Hospital Central South University,Changsha,Hunan,China[36]The First People''s Hospital of Changzhou,Changzhou,Jiangsu,China[37]Jiangsu Province Hospital,Nanjing,Jiangsu,China[38]Nantong Tumor Hospital,Nantong,Jiangsu,China[39]The Affiliated Hospital Of XuZhou Medical University,Xuzhou,Jiangsu,China[40]First Affiliated Hospital of Nanchang University,Nanchang,Jiangxi,China[41]The Second Affiliated Hospital of Nanchang University,Nanchang,Jiangxi,China[42]China-Japan Union Hospital of Jilin University,Changchun,Jilin,China[43]The First Hospital of Jilin University,Changchun,Jilin,China[44]Liaoning Cancer Hospital,Shenyang,Liaoning,China[45]The First Affiliated Hospital of China Medical University,Shenyang,Liaoning,China[46]Shandong Cancer Hospital,Jinan,Shandong,China[47]Shandong Provincial Hospital,Jinan,Shandong,China[48]Affiliated Hospital of Jining Medical University,Jining,Shandong,China[49]LINYI Cancer Hospital,Linyi,Shandong,China[50]Linyi City People Hospital,Linyi,Shandong,China[51]The Affiliated Hospital of Qingdao University,Qingdao,Shandong,China[52]Weifang People''S Hospital,Weifang,Shandong,China[53]Shanghai Changhai Hospital,Shanghai,Shanghai,China,200433[54]Yueyang Hospital of Integrated Traditional Chinese and Western Medicine , Shanghai University of Traditional Chinese Medicine,Shanghai,Shanghai,China[55]Zhongshan Hospital Fudan University,Shanghai,Shanghai,China[56]Shanxi Cancer hospital,Taiyuan,Shanxi,China[57]Shanxi Provincial People''s Hospital,Taiyuan,Shanxi,China[58]the First Affiliated Hospital of Xi''an Jiaotong University,Xi''an,Shanxi,China[59]Sichuan Cancer Hospital,Chengdu,Sichuan,China[60]Sichuan Provincial People''s Hospital,Chengdu,Sichuan,China[61]Sir Run Run Sha
研究目的：
This study is a multicenter, randomized, double-Blind Phase III Study to compare the clinical efficacy and safety of KN046 plus gemcitabine and nab-paclitaxel versus placebo plus gemcitabine and nab-paclitaxel in subjects with advanced pancreatic ductal adenocarcinoma who have not previously received systemic treatment.
