研究单位：[1]Amgen[2]Zai Lab (China only)[3]Alaska Oncology and Hematology LLC,Anchorage,Alaska,United States,99508[4]Mayo Clinic Arizona,Phoenix,Arizona,United States,85054[5]The Oncology Institute Clinical Research,Cerritos,California,United States,90703[6]University of California Los Angeles,Los Angeles,California,United States,90095[7]Mayo Clinic Florida,Jacksonville,Florida,United States,32224[8]Saint Francis Medical Group,Indianapolis,Indiana,United States,46237[9]University of Michigan,Ann Arbor,Michigan,United States,48109[10]Mayo Clinic Rochester,Rochester,Minnesota,United States,55905[11]Healthier Hematology and Oncology Excelsior Integrated Medical Group,Brooklyn,New York,United States,11220[12]White Plains Hospital Medical Center,White Plains,New York,United States,10604[13]Levine Cancer Institute University,Charlotte,North Carolina,United States,28204[14]FirstHealth Cancer Center,Pinehurst,North Carolina,United States,28374[15]Avera Cancer Institute,Sioux Falls,South Dakota,United States,57108[16]Vanderbilt University Medical Center,Nashville,Tennessee,United States,37232[17]Inova Schar Cancer Institute,Fairfax,Virginia,United States,22031[18]Medical Oncology Associates, PS,Spokane,Washington,United States,99208[19]Instituto Alexander Fleming,Caba,Buenos Aires,Argentina,C1426ANZ[20]Hospital Universitario Fundacion Favaloro,Ciudad Autonoma de Buenos Aires,Buenos Aires,Argentina,C1093AAS[21]Sociedad de Beneficencia Hospital Italiano,Cordoba,Córdoba,Argentina,5000[22]Hospital Privado Universitario de Cordoba,Cordoba,Córdoba,Argentina,X5016KEH[23]Hospital Provincial del Centenario,Rosario,Santa Fe,Argentina,S2002KDS[24]Exelsus Oncologia Clinica,San Miguel de Tucuman,Tucuman,Argentina,4000[25]Instituto Argentino de Diagnostico y Tratamiento IADT,Buenos Aires,Argentina,C1122AAL[26]Hospital Britanico de Buenos Aires,Buenos Aires,Argentina,C1280AEB[27]Liverpool Hospital,Liverpool,New South Wales,Australia,2170[28]St John of God Murdoch Hospital,Murdoch,Western Australia,Australia,6150[29]Universitair Ziekenhuis Antwerpen,Edegem,Belgium,2650[30]Universitair Ziekenhuis Gent,Gent,Belgium,9000[31]Universitair Ziekenhuis Leuven - Campus Gasthuisberg,Leuven,Belgium,3000[32]Centre Hospitalier Universitaire de Liege - Sart Tilman,Liege,Belgium,4000[33]Núcleo de Oncologia da Bahia,Salvador,Bahia,Brazil,40170-110[34]Centro de Oncologia Mackenzie,Curitiba,Paraná,Brazil,80440-220[35]Oncosite Centro de Pesquisa Clinica Em Oncologia Ltda,Ijui,Rio Grande Do Sul,Brazil,98700-000[36]Hospital Sao Lucas da Pontificia Universidade Catolica do Rio Grande do Sul,Porto Alegre,Rio Grande Do Sul,Brazil,90610-000[37]Clinica de Oncologia Reichow,Blumenau,Santa Catarina,Brazil,89010-340[38]Centro de Pesquisa e Ensino em Oncologia de Santa Catarina,Florianopolis,Santa Catarina,Brazil,88020-210[39]Instituto de Ensino e Pesquisa Sao Lucas Iep Sao Lucas,Santo Andre,São Paulo,Brazil,09060-650[40]Instituto Nacional de Cancer,Rio de Janeiro,Brazil,20231-050[41]Hospital Nove de Julho - dasa,São Paulo,Brazil,01409-001[42]Instituto Brasileiro de Controle do Cancer Ibcc,São Paulo,Brazil,04014-002[43]Multiprofile Hospital for Active Treatment Park Hospital EOOD,Branipole Village,Bulgaria,4109[44]Specialized Hospital for Active Treatment of Oncology - Haskovo EOOD,Haskovo,Bulgaria,6300[45]University Multiprofile Hospital for Active Treatment Dr Georgi Stranski EAD,Pleven,Bulgaria,5800[46]University Multiprofile Hospital for Active Treatment Pulmed OOD,Plovdiv,Bulgaria,4002[47]Acibadem City Clinic University Multiprofile Hospital for Active Treatment Tokuda EAD,Sofia,Bulgaria,1407[48]Multiprofile Hospital for Active Treatment Serdika EOOD,Sofia,Bulgaria,1632[49]Cross Cancer Institute,Edmonton,Alberta,Canada,T6G 1Z2[50]The Ottawa Hospital Cancer Centre,Ottawa,Ontario,Canada,K1H 8L6[51]Sunnybrook Research Institute Sunnybrook Health Sciences Centre,Toronto,Ontario,Canada,M4N 3M5[52]Jewish General Hospital,Montreal,Quebec,Canada,H3T 1E2[53]James Lind Centro de Investigacion del Cancer,Temuco,Cautín,Chile,4800827[54]Clinica CIDO,Temuco,Cautín,Chile,4810218[55]Centro de Estudios Clinicos SAGA Spa,Santiago,Chile,7500653[56]Centro de Estudios Clinicos e Investigaciones Medicas CeCim,Santiago,Chile,8320000[57]The First Affiliated Hospital of Bengbu Medical College,Bengbu,Anhui,China,233099[58]The First Affiliated Hospital of Anhui Medical University,Hefei,Anhui,China,230022[59]Anhui Provincial Cancer Hospital,Hefei,Anhui,China,230031[60]Cancer Hospital of Chinese Academy of Medical Sciences,Beijing,Beijing,China,100021[61]Peking Union Medical College Hospital, Chinese Academy of Medical Sciences,Beijing,Beijing,China,100032[62]Chongqing University Three Gorges Hospital,Chongqing,Chongqing,China,400037[63]Fujian Medical University Union Hospital,Fuzhou,Fujian,China,350001[64]Fujian Cancer Hospital,Fuzhou,Fujian,China,350014[65]The First Affiliated Hospital of Xiamen University,Xiamen,Fujian,China,361003[66]Lanzhou University Second Hospital,Lanzhou,Gansu,China,730030[67]Gansu Wuwei Tumour Hospital,Wuwei,Gansu,China,733000[68]Sun Yat-sen University Cancer Center,Guangzhou,Guangdong,China,510030[69]Guangdong Provincial Peoples Hospital,Guangzhou,Guangdong,China,510180[70]Sun Yat-sen University Cancer Center,Guangzhou,Guangdong,China,510700[71]Cancer Hospital of Shantou University Medical College,Shantou,Guangdong,China,515031[72]The First Affiliated Hospital of Hainan Medical University,Haikou,Hainan,China,570102[73]Fourth Hospital of Hebei Medical University,Shijiazhuang,Hebei,China,050011[74]Tongji Hospital Affiliated to Tongji Medical College of Huazhong University of ScienceandTechnology,Wuhan,Hebei,China,430030[75]Harbin Medical University Cancer Hospital,Harbin,Heilongjiang,China,150000[76]Anyang Cancer Hospital,Anyang,Henan,China,455001[77]The First Affiliated Hospital of Henan University of science and Technology,Luoyang,Henan,China,471000[78]Henan Cancer Hospital,Zhengzhou,Henan,China,450000[79]The First Affiliated Hospital of Zhengzhou University,Zhengzhou,Henan,China,450052[80]Taihe Hospital Affiliated Hospital of Hubei University of Medicine,Shiyan,Hubei,China,442000[81]Hubei Cancer Hospital,Wuhan City,Hubei,China,430079[82]The Cancer Center Union Hospital Tongji Medical College Huazhong University of Science and Tech,Wuhan,Hubei,China,430000[83]Xiangya Hospital of Central South University,Changsha,Hunan,China,410000[84]Hunan Cancer Hospital,Changsha,Hunan,China,410006[85]Nanjing First Hospital,Nanjing,Jiangsu,China,210006[86]The Second Affiliated Hospital of Soochow University,Suzhou,Jiangsu,China,215004[87]Affiliated Hospital of Jiangnan University,Wuxi,Jiangsu,China,214122[88]The Affiliated Hospital of Xuzhou Medical University,Xuzhou,Jiangsu,China,221002[89]The First Affiliated Hospital of Nanchang University,Nanchang,Jiangxi,China,330000[90]The First Hospital of Jilin University,Changchun,Jilin,China,130021[91]China-Japan Union Hospital of Jilin University,Changchun,Jilin,China,130022[92]The First Affiliated Hospital of Jinzhou Medical University,Jinzhou,Liaoning,China,121000[93]The First Hospital of China Medical University,Shenyang,Liaoning,China,110001[94]Liaoning Cancer Hospital,Shenyang,Liaoning,China,110042[95]The First Affiliated Hospital of Xi an Jiaotong University,XI An,Shaanxi,China,710061[96]Jinan Central Hospital,Jinan,Shandong,China,250013[97]The Affiliated Cancer Hospital of Shandong First Medical University,Jinan,Shandong,China,250117[98]The Affiliated Hospital of Qingdao University,Qingdao,Shandong,China,266000[99]Fudan University Shanghai Cancer Center,Shanghai,Shanghai,China,200032[100]Zhongshan Hospital Fudan University,Shanghai,Shanghai,China,200032[101]Shanghai General Hospital,Shanghai,Shanghai,China,200080[102]Shanghai East Hospital,Shanghai,Shanghai,China,200123[103]Ruijin Hospital Shanghai Jiao Tong University School of Medicine,Shanghai,Shanghai,China,201800[104]Changzhi Peoples Hospital,Changzhi,Shanxi,China,046000[105]Linfen Central Hospital,Linfen,Shanxi,China,100032[106]Shanxi Province Cancer Hospital,Taiyuan,Shanxi,China,030013[107]Sichuan Cancer Hospital,Chengdu,Sichuan,China,610041[108]The First Affiliated Hospital Zhejiang University School of Medicine,Hangzhou,Zhejiang,China,310003[109]The Second Affiliated Hospital Zhejiang University School of Medicine,Hangzhou,Zhejiang,China,310009[110]Sir Run Run Shaw Hospital Zhejiang University School of Medicine,Hangzhou,Zhejiang,China,310016[111]Taizhou Hospital of Zhejiang Province,Linhai,Zhejiang,China,317000
The main objective of this study is to compare efficacy of bemarituzumab combined with oxaliplatin, leucovorin, and 5-fluorouracil (5-FU) (mFOLFOX6) to placebo plus mFOLFOX6 as assessed by overall survival (OS) in participants with FGFR2b ≥10% 2+/3+ tumor cell staining (FGFR2b ≥10% 2+/3+TC)
