A Study to Assess Disease Activity and Adverse Events of Intravenous (IV) Telisotuzumab Vedotin Compared to IV Docetaxel in Adult Participants With Previously Treated Non-Squamous Non-Small Cell Lung Cancer (NSCLC)
研究单位：[1]AbbVie[2]The Oncology Institute of Hope and Innovation - DTLA /ID# 239774,Los Angeles,California,United States,90015-3070[3]Eisenhower Medical Center /ID# 233189,Rancho Mirage,California,United States,92270-3221[4]Ocala Oncology Florida Cancer Affiliates - Main /ID# 234228,Ocala,Florida,United States,34474-4445[5]The Queens Medical Center /ID# 250633,Honolulu,Hawaii,United States,96813[6]Kaiser Permanente Moanalua Medical Center /ID# 238363,Honolulu,Hawaii,United States,96819-1469[7]Edward-Elmhurst Cancer Center /ID# 238552,Elmhurst,Illinois,United States,60126[8]St. Joseph Mercy Hospital /ID# 232190,Ypsilanti,Michigan,United States,48197-1051[9]Hulston Cancer Center /ID# 232226,Springfield,Missouri,United States,65807-5287[10]Renown Medical Group - Oncology/Hematology /ID# 247942,Reno,Nevada,United States,89502-1464[11]San Juan Oncology Associates /ID# 244387,Farmington,New Mexico,United States,87401[12]Maimonides Medical Center /ID# 240783,Brooklyn,New York,United States,11219[13]First Health of the Carolinas /ID# 241279,Pinehurst,North Carolina,United States,28374[14]Genesis Cancer Care Center /ID# 239190,Zanesville,Ohio,United States,43701-1406[15]Avera Cancer Institute /ID# 239635,Sioux Falls,South Dakota,United States,57105[16]Centro Médico Austral /ID# 239860,Ciudad Autonoma Buenos Aires,Ciuadad Autonoma De Buenos Aires,Argentina,1019[17]Instituto de Oncologia Angel H. Roffo /ID# 231499,Ciudad Autonoma Buenos Aires,Ciuadad Autonoma De Buenos Aires,Argentina,1417[18]Cenit /Id# 239880,Ciudad Autonoma de Buenos Aire,Ciuadad Autonoma De Buenos Aires,Argentina,1125[19]Hospital Britanico de Buenos Aires /ID# 231495,Ciudad Autonoma de Buenos Aire,Ciuadad Autonoma De Buenos Aires,Argentina,1280[20]Cemic /Id# 231486,Ciudad Autonoma de Buenos Aire,Ciuadad Autonoma De Buenos Aires,Argentina,1431[21]Centro de Investigaciones Clinicas Clinica Viedma S.A. /ID# 232339,Viedma,Rio Negro,Argentina,8500[22]Barwon Health /ID# 241920,Geelong,Victoria,Australia,3220[23]Austin Health /ID# 247507,Heidelberg,Victoria,Australia,3084[24]Ordensklinikum Linz GmbH Elisabethinen /ID# 240967,Linz,Oberoesterreich,Austria,4010[25]Klinikum Wels-Grieskirchen GmbH /ID# 249000,Wels,Oberoesterreich,Austria,4600[26]Medizinische Universitaet Innsbruck /ID# 240981,Innsbruck,Tirol,Austria,6020[27]Landeskrankenhaus Feldkirch /ID# 250333,Feldkirch,Vorarlberg,Austria,6800[28]Medizinische Universitaet Wien /ID# 230615,Vienna,Wien,Austria,1090[29]Klinik Penzing /ID# 230700,Vienna,Wien,Austria,1140[30]Klinik Floridsdorf /ID# 230608,Vienna,Wien,Austria,1210[31]Landeskrankenhaus Salzburg-Universitätsklinikum der PMU (LKH) /ID# 232467,Salzburg,Austria,5020[32]Universitair Ziekenhuis Antwerpen /ID# 239971,Edegem,Antwerpen,Belgium,2650[33]Grand Hopital de Charleroi /ID# 234178,Charleroi,Hainaut,Belgium,6000[34]AZ Klina /ID# 239853,Brasschaat,Belgium,2930[35]Ensino e Terapia de Inovacao Clínica AMO - Etica /ID# 231604,Salvador,Bahia,Brazil,41830-907[36]Irmandade da Santa Casa de Misericórdia de Porto Alegre /ID# 233249,Porto Alegre,Rio Grande Do Sul,Brazil,90020-090[37]Fundacao Pio XII - Hospital de Cancer de Barretos /ID# 233247,Barretos,Sao Paulo,Brazil,14784-400[38]Instituto Nacional de Câncer José Alencar Gomes da Silva (INCA) /ID# 231509,Rio de Janeiro,Brazil,20231-050[39]Instituto D'or de Pesquisa e Ensino /ID# 233245,Rio de Janeiro,Brazil,22281-100[40]Instituto de Ensino e Pesquisa Sao Lucas /ID# 247417,Sao Paulo,Brazil,01236-030[41]Casa de Saúde Santa Marcelina /ID# 231605,Sao Paulo,Brazil,08270-070[42]Complex Oncology Center - Burgas /ID# 240532,Burgas,Bulgaria,8000[43]UMHAT Sofiamed /ID# 234108,Sofia,Bulgaria,1797[44]UMHAT Sveta Marina /ID# 234112,Varna,Bulgaria,9010[45]CISSS de la Monteregie /ID# 239081,Greenfield Park,Quebec,Canada,J4V 2H1[46]Clinica Universidad Catolica del Maule /ID# 231294,Talca,Maule,Chile,3461341[47]Icegclinic /Id# 231212,La Florida,Region Metropolitana De Santiago,Chile,8241479[48]Sociedad Prosalud Montes y Orlandi /ID# 231154,Providencia,Region Metropolitana De Santiago,Chile,7500713[49]Fundacion Arturo Lopez Perez /ID# 231151,Providencia,Region Metropolitana Santiago,Chile,7500921[50]Sociedad Oncovida /ID# 231152,Providencia,Region Metropolitana Santiago,Chile,7510032[51]Anhui Chest Hospital /ID# 231899,Hefei,Anhui,China,230022[52]Peking Union Medical College Hospital /ID# 233175,Beijing,Beijing,China,100032[53]Beijing Cancer Hospital /ID# 231923,Beijing,Beijing,China,100142[54]Beijing Chest Hospital, Capital Medical University /ID# 232202,Beijing,Beijing,China,101149[55]The First Affiliated Hospital of Chongqing Medical University /ID# 251592,Chongqing,Chongqing,China,400016[56]Fujian Provincial Cancer Hospital /ID# 243134,Fuzhou,Fujian,China,350014[57]The First Affiliated Hospital of Xiamen University /ID# 242381,Xiamen,Fujian,China,361003[58]The First Affiliated Hospital of Guangzhou Medical University /ID# 238591,Guangzhou,Guangdong,China,510163[59]Cancer Hospital of Shantou University Medical College /ID# 242182,Shantou,Guangdong,China,515041[60]Affiliated Hospital Of Guangdong Medical University /ID# 233317,Zhanjiang,Guangdong,China,524011[61]Guangxi Medical University Cancer Center /ID# 231855,Nanning,Guangxi,China,530027[62]Guizhou Provincial People''s Hospital /ID# 243614,Guiyang,Guizhou,China,550002[63]Affiliated Hospital of Hebei University /ID# 239586,Baoding,Hebei,China,071000[64]Harbin Medical University Cancer Hospital /ID# 231941,Harbin,Heilongjiang,China,150081[65]The First affiliated Hospital of Nanyang Medical College /ID# 244652,Nanyang,Henan,China,473007[66]Henan Provincial People''s Hospital /ID# 242187,Zhengzhou,Henan,China,450003[67]Henan Cancer Hospital /ID# 239577,Zhengzhou,Henan,China,450008[68]Union Hospital Tongji Medical College Huazhong University of Science and Technol /ID# 231904,Wuhan,Hubei,China,430022[69]Tongji Hospital Tongji Medical College of HUST /ID# 239575,Wuhan,Hubei,China,430030[70]Hubei Cancer Hospital /ID# 240045,Wuhan,Hubei,China,430079[71]Hunan Cancer Hospital /ID# 231943,Changsha,Hunan,China,410006[72]Xiangya Hospital Central South University /ID# 232005,Changsha,Hunan,China,410008[73]The Affiliated Hospital of Inner Mongolia Medical University /ID# 242179,Huhehaote,Inner Mongolia,China,010050[74]Nanjing Drum Tower Hospital /ID# 231791,Nanjing,Jiangsu,China,210008[75]Nantong Tumor Hospital /ID# 232424,Nantong,Jiangsu,China,226300[76]The First Affiliated Hospital of Nanchang University /ID# 231934,Nanchang,Jiangxi,China,330006[77]The Second Affiliated Hospital of Nanchang University /ID# 231935,Nanchang,Jiangxi,China,330008[78]Jilin Cancer Hospital /ID# 244702,Changchun,Jilin,China,130012[79]The First Hospital of China Medical University /ID# 231924,Shenyang,Liaoning,China,110001[80]Jinan Central Hospital /ID# 231895,Jinan,Shandong,China,250013[81]Shandong Cancer Hospital /ID# 251506,Jinan,Shandong,China,251601[82]The First Affiliated Hospital of Xi''an Jiaotong University /ID# 232023,Xian,Shanxi,China,710061[83]Sichuan Cancer Hospital /ID# 239707,Chengdu,Sichuan,China,610041[84]West China Hospital, Sichuan University /ID# 233703,Chengdu,Sichuan,China,610041[85]Tianjin Medical University Cancer Institute and Hospital /ID# 233176,Tianjin,Tianjin,China,300222[86]Yunnan Cancer Hospital /ID# 251388,Kunming,Yunnan,China,650118[87]The First Affiliated Hospital, Zhejiang University School of Medicine /ID# 232032,Hangzhou,Zhejiang,China,310006[88]Zhejiang Cancer hospital /ID# 242476,Hangzhou,Zhejiang,China,310022[89]Taizhou Hospital, Zhejiang Province /ID# 232021,Taizhou,Zhejiang,China,317013[90]The First Affiliated Hospital of Dalian Medical University /ID# 239717,Dalian,China,116011[91]The Second Hospital of Dalian Medical University /ID# 239755,Dalian,China,116027[92]Linyi Cancer Hospital /ID# 239713,Linyi,China,276000[93]Ningbo No. 2 Hospital /ID# 242478,Ningbo,China,315010[94]Shanghai Chest Hospital /ID# 231897,Shanghai,China,200030[95]Tianjin Medical University General Hospital /ID# 231839,Tianjin,China,300052[96]Masarykuv onkologicky ustav /ID# 232426,Brno,Czechia,656 53[97]Nemocnice AGEL Novy Jicin, a.s. /ID# 232427,Novy Jicin,Czechia,741 01[98]Sjællands Universitetshospital, Roskilde /ID# 241842,Roskilde,Sjælland,Denmark,4000[99]Odense University Hospital /ID# 241663,Odense C,Syddanmark,Denmark,5000[100]CHU Bordeaux - Hopital Haut Leveque /ID# 244953,Pessac,Gironde,France,33604[101]Institut Curie /ID# 240141,Paris CEDEX 05,Ile-de-France,France,75248[102]Hopital Arnaud de Villeneuve /ID# 239404,Montpellier Cedex 5,France,34295[103]AP-HP - Hopital Cochin /ID# 239409,Paris,France,75014[104]AP-HP - Hopital Tenon /ID# 239179,Paris,France,75020[105]Universitatsklinikum Mannheim /ID# 238331,Mannheim,Baden-Wuerttemberg,Germany,68167[106]Universitaetsklinikum Giessen /ID# 252973,Gießen,Hessen,Germany,35392[107]Universitaetsklinikum Jena /ID# 239661,Jena,Thueringen,Germany,07747[108]Universitaetsklinikum Hamburg-Eppendorf (UKE) /ID# 239658,Hamburg,Germany,20246[109]Haemato-Onkologie Hamburg /ID# 241047,Hamburg,Germany,20251[110]Thoraxklinik Heidelberg gGmbH /ID# 239656,Heidelberg,Germany,69126[111]Klinikum Kassel /ID# 240142,Kassel,Germany,34125[112]General Hospital of Chest Diseases of Athens SOTIRIA /ID# 230824,Athens,Attiki,Greece,11527[113]Metropolitan Hospital /ID# 232158,Piraeus,Attiki,Greece,18547[114]Metropolitan Hospital /ID# 239170,Piraeus,Attiki,Greece,18547[115]Euromedica General Clinic /ID# 254407,Thessaloniki,Greece,54645[116]The Edith Wolfson Medical Center /ID# 233781,Holon,Israel,5822000[117]Ziv Medical Center /ID# 238606,Safed,Israel,13100[118]Ospedale San Raffaele IRCCS /ID# 254376,Milan,Milano,Italy,20132[119]Azienda Ospedaliera San Giovanni Addolorata /ID# 238618,Rome,Roma,Italy,00184[120]Azienda Ospedaliera di Perugia /ID# 238473,Perugia,Umbria,Italy,06129[121]I.R.C.C.S Istituto Tumori Giovanni Paolo II /ID# 238696,Bari,Italy,70124[122]Azienda Socio Sanitaria Territoriale di Cremona /ID# 238698,Cremona,Italy,26100[123]Azienda Ospedaliero-Universitaria di Parma /ID# 252943,Parma,Italy,43126[124]ASST Sette Laghi /ID# 238536,Varese,Italy,21100[125]NHO Nagoya Medical Center /ID# 246306,Nagoya-shi,Aichi,Japan,460-0001[126]Nagoya University Hospital /ID# 239990,Nagoya-shi,Aichi,Japan,4668560[127]Hirosaki University Hospital /ID# 242377,Hirosaki-shi,Aomori,Japan,036-8203[128]National Cancer Center Hospital East /ID# 233775,Kashiwa-shi,Chiba,Japan,277-8577[129]National Hospital Organization Kyushu Medical Center /ID# 238533,Fukuoka shi,Fukuoka,Japan,810-8563[130]Hospital of the University of Occupational and Environmental Health, Japan /ID# 241191,Kitakyushu-shi,Fukuoka,Japan,807-8556[131]Fukushima Medical University Hospital /ID# 249691,Fukushima-shi,Fukushima,Japan,960-1295[132]Gunma Prefectural Cancer Center /ID# 233723,Ota-shi,Gunma,Japan,373-8550[133]Chugoku Central Hospital /ID# 242970,Fukuyama-shi,Hiroshima,Japan,720-0001[134]Hiroshima University Hospital /ID# 241882,Hiroshima-shi,Hiroshima,Japan,734-8551[135]Hokkaido University Hospital /ID# 241289,Sapporo-shi,Hokkaido,Japan,060-8648[136]Kobe Minimally Invasive Cancer Center /ID# 254131,Kobe-shi,Hyogo,Japan,650-0046[137]Takarazuka City Hospital /ID# 240786,Takarazuka-shi,Hyogo,Japan,665-0827[138]National Hospital Organization Mito Medical Center /ID# 241709,Higashi Ibaraki-gun,Ibaraki,Japan,311-3193[139]Ibaraki Prefectural Central Hospital /ID# 246145,Kasama-shi,Ibaraki,Japan,309-1793[140]Iwate Medical University Hospital /ID# 239027,Shiwa-gun,Iwate,Japan,028-3695[141]Kitasato University Hospital /ID# 239958,Sagamihara-shi,Kanagawa,Japan,252-0375[142]Yokohama City University Medical Center /ID# 246554,Yokohama shi,Kanagawa,Japan,232-0024[143]Kanagawa Cardiovascular and Respiratory Center /ID# 239052,Yokohama-shi,Kanagawa,Japan,236-0051[144]Kumamoto University Hospital /ID# 241039,Kumamoto shi,Kumamoto,Japan,8608556[145]National Hospital Organization Mie Chuo Medical Center /ID# 246659,Tsu-shi,Mie,Japan,514-1101[146]Miyagi Cancer Center /ID# 234198,Natori-shi,Miyagi,Japan,981-1293[147]Sendai Kousei Hospital /ID# 253350,Sendai-shi,Miyagi,Japan,980-0873[148]University of Miyazaki Hospital /ID# 242161,Miyazaki-shi,Miyazaki,Japan,889-1692[149]Nagaoka Red Cross Hospital /ID# 240714,Nagaoka-shi,Niigata,Japan,940-2085[150]Kurashiki Central Hospital /ID# 239344,Kurashiki-shi,Okayama,Japan,710-8602[151]Osaka Habikino Medical Center /ID# 239989,Habikino-shi,Osaka,Japan,583-8588[152]Kansai Medical University Hospital /ID# 233476,Hirakata-shi,Osaka,Japan,573-1191[153]Osaka Metropolitan University Hospital /ID# 238895,Osaka-shi,Osaka,Japan,545-8586[154]Kindai University Hospital /ID# 239085,Osakasayama-shi,Osaka,Japan,589-8511[155]Tochigi Cancer Center /ID# 240020,Utsunomiya-shi,Tochigi,Japan,320-0834[156]Juntendo University Hospital /ID# 239932,Bunkyo-ku,Tokyo,Japan,113-8431[157]National Hospital Organization Tokyo Medical Center /ID# 246581,Meguro-ku,Tokyo,Japan,152-8902[158]NTT Medical Center Tokyo /ID# 241067,Shinagawa-ku,Tokyo,Japan,141-8625[159]Keio University Hospital /ID# 239506,Shinjuku-ku,Tokyo,Japan,160-8582[160]Toyama University Hospital /ID# 241660,Toyama-shi,Toyama,Japan,930-0194[161]Wakayama Medical University Hospital /ID# 234004,Wakayama-shi,Wakayama,Japan,641-8510[162]Yamagata University Hospital /ID# 240815,Yamagata-shi,Yamagata,Japan,990-9585[163]CHA University Bundang Medical Center /ID# 233318,Seongnam si,Gyeonggido,Korea, Republic of,13496[164]Ajou University Hospital /ID# 233319,Suwon,Gyeonggido,Korea, Republic of,16499[165]Gyeongsang National University Hospital /ID# 234244,Jinju,Gyeongsangnamdo,Korea, Republic of,52727[166]Kangbuk Samsung Hospital /ID# 233711,Seoul,Seoul Teugbyeolsi,Korea, Republic of,03181[167]SMG-SNU Boramae Medical Center /ID# 233710,Seoul,Seoul Teugbyeolsi,Korea, Republic of,07061[168]Hospital Civil de Guadalajara Fray Antonio Alcalde /ID# 238488,Guadalajara,Jalisco,Mexico,44280[169]Centro de Investigacion Clínica Chapultepec SA de CV /ID# 231928,Morelia,Michoacan,Mexico,58260[170]Hospital Universitario Dr. Jose Eleuterio Gonzalez /ID# 231880,Monterrey,Nuevo Leon,Mexico,64460[171]Clinical Research & Oncology Oaxaca /ID# 231883,Oaxaca,Mexico,68020[172]Radboud Universitair Medisch Centrum /ID# 233755,Nijmegen,Gelderland,Netherlands,6525 GA[173]HagaZiekenhuis /ID# 243693,Den Haag,Netherlands,2545 AA[174]Maastricht Universitair Medisch Centrum /ID# 233932,Maastricht,Netherlands,6229 HX[175]Isala /ID# 238846,Zwolle,Netherlands,8025 AB[176]Instytut Centrum Zdrowia Matki Polki /ID# 239024,Lodz,Lodzkie,Poland,93-338[177]MRUK-MED I Sp. Z o.o. /ID# 239363,Rzeszow,Podkarpackie,Poland,35-021[178]Warminsko-Mazurskie Centrum Chorob Pluc w Olsztynie /ID# 239025,Olsztyn,Warminsko-mazurskie,Poland,10-357[179]Fundação Champalimaud /ID# 241925,Lisboa,Portugal,1400-038[180]Centro Hospitalar Universitario do Porto, EPE - Hospital Santo Antonio /ID# 241572,Porto,Portugal,4099-001[181]Hospital CUF Porto /ID# 241570,Porto,Portugal,4100-180[182]IPO Porto FG, EPE /ID# 241569,Porto,Portugal,4200-072[183]Centro Hospitalar Universitario de Sao Joao, EPE /ID# 241930,Porto,Portugal,4200-319[184]Oncocenter - Oncologie Clinica Srl /Id# 239103,Timisoara,Timis,Romania,300166[185]Centrul Medical de Diagnostic si Tratament Ambulator Neomed SRL /ID# 240826,Brasov,Romania,500283[186]Sc Oncolab Srl /Id# 239105,Craiova,Romania,200385[187]SC RTC Radiology Therapeutic Center SRL /ID# 240744,Otopeni,Romania,075100[188]S.C. Sigmedical Services SRL /ID# 239108,Suceava,Romania,720214[189]Fakultna nemocnica s poliklinikou F.D. Roosevelta Banska Bystrica /ID# 230084,Banska Bystrica,Slovakia,975 17[190]Wits Clinical Research Site /ID# 230841,Johannesburg,Gauteng,South Africa,2193[191]Sandton Oncology Medical Group PTY Ltd /ID# 230843,Johannesburg,Gauteng,South Africa,2196[192]Dept of Oncology Steve Biko Academic Hospital /ID# 230883,Pretoria,Gauteng,South Africa,0002[193]UOMi Cancer Center - Clinica Tres Torres /ID# 240584,Barcelona,Spain,08017[194]Hospital Universitario de Jaen /ID# 240588,Jaen,Spain,23007[195]Hospital Universitario 12 de Octubre /ID# 240176,Madrid,Spain,28041[196]Hospital Clinico Universitario de Valencia /ID# 240378,Valencia,Spain,46010[197]Sahlgrenska University Hospital /ID# 229943,Gothenburg,Vastra Gotalands Lan,Sweden,413 45[198]Karolinska University Hospital /ID# 229853,Stockholm,Sweden,171 76[199]Universitätsspital Basel /ID# 252422,Basel,Basel-Stadt,Switzerland,4031[200]Changhua Christian Hospital /ID# 238394,Changhua City, Changhua County,Taiwan,50006[201]National Taiwan University Hospital - Hsinchu branch /ID# 238393,Hsinchu City,Taiwan,30059[202]Hualien Tzu Chi Hospital /ID# 238398,Hualien City,Taiwan,97002[203]E-DA Cancer Hospital /ID# 239718,Kaohsiung City,Taiwan,82445[204]Chung Shan Medical University Hospital /ID# 238444,Taichung,Taiwan,40201[205]National Taiwan University Hospital /ID# 238378,Taipei City,Taiwan,100[206]MacKay Memorial Hospital /ID# 238392,Taipei City,Taiwan,10449[207]Taipei Medical University Hospital /ID# 238380,Taipei City,Taiwan,11031[208]Memorial Ankara Hastanesi /ID# 234212,Çankaya,Ankara,Turkey,06520[209]Izmir Ekonomi Universitesi Ozel Medicalpoint Hastanesi /ID# 234209,Karsiyaka,Izmir,Turkey,35575[210]Adana Acibadem Hospital /ID# 234208,Adana,Turkey,01130[211]Ankara City Hospital /ID# 234210,Ankara,Turkey,06800[212]Inonu Universitesi Turgut Ozal /ID# 234038,Battalgazi/malatya,Turkey,44280[213]Uludag University Medical Faculty /ID# 234205,Bursa,Turkey,16059[214]Dicle Universitesi Tip /ID# 234036,Diyarbakir,Turkey,21200[215]Bagcilar Medipol Mega Universite Hastanesi /ID# 234211,Istanbul,Turkey,34214[216]Ege University Medical Faculty /ID# 234039,Izmir,Turkey,35040[217]Baskent Universitesi Adana Dr. Turgut Noyan Uyg. Ve Arast. Merkezi /ID# 238337,Yuregir,Turkey,01250[218]University College London Hospitals NHS Foundation Trust /ID# 249407,London,United Kingdom,NW1 2PG[219]The Royal Marsden NHS Foundation Trust /ID# 246974,London,United Kingdom,SW3 6JJ[220]The Christie Hospital /ID# 243422,Manchester,United Kingdom,M20 4BX
Cancer is a condition where cells in a specific part of body grow and reproduce uncontrollably. Non-small cell lung cancer (NSCLC) is a solid tumor, a disease in which cancer cells form in the tissues of the lung. The purpose of this study is to determine if telisotuzumab vedotin works better than docetaxel and to assess how safe telisotuzumab vedotin is in adult participants with NSCLC who have previously been treated. Change in disease activity and adverse events will be assessed. Telisotuzumab vedotin is an investigational drug being developed for the treatment of NSCLC. Participants will be randomly assigned a treatment of Teliso-V or Docetax at an 1:1 ratio. Each group receives intravenous (IV) infusion of telisotuzumab vedotin or IV infusion of docetaxel. Approximately 698 adult participants with c-Met overexpressing NSCLC will be enrolled in the study in approximately 250 sites worldwide. Participants will receive IV telisotuzumab vedotin every 2 weeks or docetaxel every 3 weeks until meeting study drug discontinuation criteria. There may be higher treatment burden for participants in this trial compared to their standard of care. Participants will attend regular visits during the study at a hospital or clinic. The effect of the treatment will be checked by medical assessments, blood tests, checking for side effects and completing questionnaires.
