研究单位：[1]Seagen Inc.[2]Genmab[3]University of Alabama at Birmingham,Birmingham,Alabama,United States,35294-3300[4]Arizona Oncology Associates, PC - HAL,Phoenix,Arizona,United States,85016[5]Arizona Oncology Associates, PC - HOPE,Tucson,Arizona,United States,85710[6]University of California Irvine Medical Center,Irvine,California,United States,92697[7]Olive View - UCLA Medical Center,Sylmar,California,United States,91342[8]Yale Cancer Center,New Haven,Connecticut,United States,06520[9]Broward Health Medical Center,Fort Lauderdale,Florida,United States,33316[10]Augusta University,Augusta,Georgia,United States,30912[11]Northwestern Memorial Hospital,Chicago,Illinois,United States,60611[12]Gynecological Cancer Institute of Chicago, LLC,Oak Lawn,Illinois,United States,60453[13]Norton Cancer Institute,Louisville,Kentucky,United States,40207[14]Willis-Knighton Physician Network/Gynecologic Oncology Associates,Shreveport,Louisiana,United States,71103[15]Maryland Oncology Hematology, P.A.,Columbia,Maryland,United States,21044[16]Minnesota Oncology Hematology P.A.,Minneapolis,Minnesota,United States,55404[17]St. Dominic - Jackson Memorial Hospital,Jackson,Mississippi,United States,39216[18]Washington University in St Louis,Saint Louis,Missouri,United States,63108[19]Weill Cornell Medicine,Brooklyn,New York,United States,11215[20]Weill Cornell Medicine,Flushing,New York,United States,11355[21]New York University (NYU) Cancer Institute,New York,New York,United States,10016[22]UNC Lineberger Comprehensive Cancer Center / University of North Carolina,Chapel Hill,North Carolina,United States,27599[23]Cleveland Clinic Fairview Hospital,Cleveland,Ohio,United States,44111[24]Cleveland Clinic, The,Cleveland,Ohio,United States,44195[25]Ohio State University Clinical Trials Management Office,Hilliard,Ohio,United States,43026[26]Kettering Health,Kettering,Ohio,United States,45429[27]Cleveland Clinic Hillcrest Hospital,Mayfield Heights,Ohio,United States,44124[28]Oncology Associates of Oregon,Eugene,Oregon,United States,97401[29]Northwest Cancer Specialists, P.C.,Portland,Oregon,United States,97227[30]Texas Oncology - Austin Central,Austin,Texas,United States,78731[31]Texas Oncology - Fort Worth 12th Avenue,Fort Worth,Texas,United States,76104[32]Texas Oncology - The Woodlands,The Woodlands,Texas,United States,77380[33]Texas Oncology - Tyler,Tyler,Texas,United States,75702[34]University of Virginia,Charlottesville,Virginia,United States,22901[35]Virginia Oncology Associates,Norfolk,Virginia,United States,23502[36]Virginia Commonwealth University Medical Center,Richmond,Virginia,United States,23219[37]Carbone Cancer Center / University of Wisconsin,Madison,Wisconsin,United States,53792[38]Instituto Oncologico de Cordoba,Córdoba,Other,Argentina,X5006HBF[39]Fundacion Cenit,Caba,Argentina,1125[40]Instituto Alexander Fleming,Caba,Argentina,1426[41]Sanatorio de la Mujer,Rosario,Argentina,2000[42]LKH- Universitat Klinikum Graz,Graz,Other,Austria,8036[43]AKH - Medizinische Universitat Wien,Vienna,Other,Austria,1090[44]Institut Jules Bordet,Anderlecht,Other,Belgium,B-1070[45]ZNA Middelheim,Antwerpen,Other,Belgium,2020[46]Cliniques Universitaires Saint Luc,Brussels,Other,Belgium,1200[47]Universitair Ziekenhuis Gent,Gent,Other,Belgium,9000[48]UZ Leuven campus Gasthuisberg,Leuven,Other,Belgium,3000[49]CHU de Liege,Liege,Other,Belgium,4000[50]CHU UCL Namur-Site de Saint Elisabeth,Namur,Other,Belgium,5000[51]Grand Hopital de Charleroi,Charleroi,Belgium,6000[52]Hospital Mãe de Deus,Porto Alegre,Other,Brazil,90110-270[53]Erasto Gaertner Hospital,CuriBba,Brazil,81520-060[54]Instituto Brasileiro de Controle do Cancer,Formosa,Brazil,73801-340[55]Hospital de Caridade de Ijuí,Ijuí,Brazil[56]Centro de PesquisaemOncologia - HSL-PUCRS,Porto Alegre, Rio Grande Do Sul,Brazil,90610-000[57]Brazilian National Cancer Institute,Rio de Janeiro,Brazil,20220---280[58]Fundação Natonio Prudente (AC Camargo Cancer Center),Sao Paulo,Brazil,01509-010[59]Hospital Beneficencia Portuguesa,São Paulo,Brazil,01323-001[60]University of Alberta / Cross Cancer Institute,Edmonton,Alberta,Canada,T6G 1Z2[61]British Columbia Cancer Agency - Vancouver Centre,Vancouver,British Columbia,Canada,V5Z 4E6[62]Sunnybrook Health Sciences Centre,Toronto,Ontario,Canada,M4N 3M5[63]University Health Network, Princess Margaret Hospital,Toronto,Ontario,Canada,M5G 2M9[64]Centre Hospitalier de l''Universite de Montreal,Montreal,Quebec,Canada,H2X 3E4[65]Saskatoon Cancer Centre,Saskatoon,Saskatchewan,Canada,S7N 4H4[66]Cancer Hospital Chinese Academy of Medical Sciences,Beijing,Other,China,100021[67]Beijing Obstetrics and Gynecology Hospital,Beijing,Other,China,100026[68]Peking University People''s Hospital,Beijing,Other,China,100044[69]Jilin University - First Affiliated Hospital - Cancer Center,Changchun,Other,China,130000[70]The Third Xiangya Hospital of Central South University,Changsha,Other,China,410008[71]Hunan Cancer Hospital,Changsha,Other,China,410013[72]Sichuan Cancer Hospital,Chengdu,Other,China,610041[73]Chongqing Cancer Hospital,Chongqing,Other,China,400030[74]Sun Yat-sen University Cancer Center,Guangzhou City,Other,China,510060[75]Zhejiang Cancer Hospital,Hangzhou City,Other,China,310022[76]Shandong Cancer Hospital,Jinan,Other,China,250117[77]Shanghai First People''s Hospital,Shanghai,Other,China,200060[78]Liaoning Cancer Hospital and Institute,Shenyang,Other,China,110042
This trial is being done to find out whether tisotumab vedotin works better than chemotherapy to treat cervical cancer. People in this study have cervical cancer that has spread to other parts of the body (metastatic) or has come back after being treated (recurrent). Participants in this trial will be randomly assigned to one of two groups. One group will be treated with tisotumab vedotin. Participants in the other group will get one of five different chemotherapy drugs (topotecan, vinorelbine, gemcitabine, pemetrexed, or irinotecan). Participants and their doctors will know which group they are in. Participants in the chemotherapy group will decide with their study doctor which drug they will take.
