Study of Pembrolizumab (MK-3475) in Combination With Adjuvant Chemotherapy With or Without Radiotherapy in Participants With Newly Diagnosed Endometrial Cancer After Surgery With Curative Intent (MK-3475-B21 / KEYNOTE-B21 / ENGOT-en11 / GOG-3053)
研究单位：[1]Merck Sharp & Dohme LLC[2]European Network for Gynaecological Oncological Trial Groups[3]Gynecologic Oncology Group[4]University of Alabama - Birmingham ( Site 3061),Birmingham,Alabama,United States,35249[5]University of South Alabama, Mitchell Cancer Institute ( Site 3058),Mobile,Alabama,United States,36604[6]HonorHealth Research Institute - Biltmore ( Site 3043),Phoenix,Arizona,United States,85016[7]Arizona Oncology Associates PC- HOPE ( Site 3049),Tucson,Arizona,United States,85711[8]UCSD Moores Cancer Center ( Site 3053),La Jolla,California,United States,92093-0698[9]University Of Colorado ( Site 3051),Aurora,Colorado,United States,80045[10]Smilow Cancer Hospital at Yale New Haven ( Site 3070),New Haven,Connecticut,United States,06511[11]Mount Sinai Cancer Center ( Site 3081),Miami Beach,Florida,United States,33140[12]Northside Hospital ( Site 3036),Atlanta,Georgia,United States,30342[13]Northwestern Memorial Hospital ( Site 3044),Chicago,Illinois,United States,60611[14]Parkview Cancer Institute ( Site 3067),Fort Wayne,Indiana,United States,46845[15]Indiana University Melvin and Bren Simon Cancer Center ( Site 3071),Indianapolis,Indiana,United States,46202[16]University of Iowa Hospital and Clinics ( Site 3046),Iowa City,Iowa,United States,52242[17]Norton Cancer Institute - St. Matthews ( Site 3056),Louisville,Kentucky,United States,40207[18]WK Physicians Network/Gynecologic Oncology Associates ( Site 3047),Shreveport,Louisiana,United States,71103[19]University of Massachusetts Medical School ( Site 3037),Worcester,Massachusetts,United States,01655[20]Montefiore Medical Center ( Site 3065),Bronx,New York,United States,10461[21]Perlmutter Cancer Center at NYU Langone Hospital - Long Island ( Site 3076),Mineola,New York,United States,11501[22]Laura and Isaac Perlmutter Cancer Center at NYU Langone Health ( Site 3042),New York,New York,United States,10016[23]Duke Cancer Center ( Site 3072),Durham,North Carolina,United States,27710[24]Sanford Fargo Medical Center-Roger Maris Cancer Center ( Site 3080),Fargo,North Dakota,United States,58122[25]The James Cancer Hospital and Solove Research Institute at The Ohio State University Comprehensive C,Columbus,Ohio,United States,43210[26]Legacy Good Samaritan Medical Center ( Site 3033),Portland,Oregon,United States,97210[27]Sidney Kimmel Cancer Center - Jefferson Health ( Site 3078),Philadelphia,Pennsylvania,United States,19107[28]AHN West Penn Hospital ( Site 3060),Pittsburgh,Pennsylvania,United States,15224[29]Abington Hospital - Asplundh Cancer Center ( Site 3073),Willow Grove,Pennsylvania,United States,19090[30]Sanford Gynecology Oncology ( Site 3045),Sioux Falls,South Dakota,United States,57104[31]UT Southwestern Medical Center ( Site 3063),Dallas,Texas,United States,75390[32]VCU Massey Cancer Center ( Site 3068),Richmond,Virginia,United States,23298[33]Centro de Oncología e Investigación de Buenos Aires ( Site 1005),Berazategui,Buenos Aires,Argentina,B1884BBF[34]IDIM Instituto de Diagnostico e Investigaciones Metabolicas ( Site 1006),Caba,Buenos Aires,Argentina,C1012AAR[35]Instituto de Investigaciones Clinicas Mar del Plata ( Site 1003),Mar del Plata,Buenos Aires,Argentina,B7600FZO[36]Hospital Britanico de Buenos Aires ( Site 1002),Buenos Aires,Caba,Argentina,C1280AEB[37]Instituto de Oncologia de Rosario ( Site 1004),Rosario,Santa Fe,Argentina,S2000KZE[38]IDIM - Instituto de Diagnóstico e Investigaciones Metabólicas ( Site 1010),Buenos Aires,Argentina,C1012AAR[39]Hospital Aleman ( Site 1001),Buenos Aires,Argentina,C1118AAT[40]CEMIC ( Site 1009),Buenos Aires,Argentina,C1431FWO[41]Centro Oncologico Riojano Integral ( Site 1007),La Rioja,Argentina,F5300COE[42]Medizinische Universitat Graz ( Site 2004),Graz,Steiermark,Austria,8036[43]Medizinische Universitaet Innsbruck ( Site 2001),Innsbruck,Tirol,Austria,6020[44]Saint-Luc UCL ( Site 2042),Bruxelles,Bruxelles-Capitale, Region De,Belgium,1200[45]C.I.U. Hopital Ambroise Pare ( Site 2039),Mons,Hainaut,Belgium,7000[46]CHR Verviers ( Site 2035),Verviers,Liege,Belgium,4800[47]OLV Ziekenhuis ( Site 2038),Aalst,Oost-Vlaanderen,Belgium,9300[48]AZ Maria Middelares Gent ( Site 2032),Gent,Oost-Vlaanderen,Belgium,9000[49]Universitair Ziekenhuis Gent ( Site 2037),Gent,Oost-Vlaanderen,Belgium,9000[50]AZ Nikolaas ( Site 2031),Sint-Niklaas,Oost-Vlaanderen,Belgium,9100[51]UZ Leuven ( Site 2040),Leuven,Vlaams-Brabant,Belgium,3000[52]AZ Groeninge ( Site 2036),Kortrijk,West-Vlaanderen,Belgium,8500[53]CHC - Groupe Sante ( Site 2041),Liege,Belgium,4000[54]CHU Liege Sart-Tilman ( Site 2044),Liege,Belgium,4000[55]Tom Baker Cancer Centre ( Site 3007),Calgary,Alberta,Canada,T2N 4N2[56]Kingston Health Sciences Centre ( Site 3003),Kingston,Ontario,Canada,K7L 2V7[57]Centre Hospitalier de l Universite de Montreal - CHUM ( Site 3006),Montreal,Quebec,Canada,H2X 0C1[58]McGill University Health Centre ( Site 3005),Montreal,Quebec,Canada,H4A 3J1[59]Centre intégré de cancérologie du CHU de Québec Université Laval, Hôpital de l'Enfant-Jésus ( Site 3,Quebec City,Quebec,Canada,G1J 1Z4[60]Centro Investigación del Cáncer James Lind ( Site 1061),Temuco,Araucania,Chile,4800827[61]Fundacion Arturo Lopez Perez FALP ( Site 1062),Santiago,Region M. De Santiago,Chile,7500921[62]Centro de Cancer Nuestra Senora de la Esperanza ( Site 1063),Santiago,Region M. De Santiago,Chile,8330032[63]Bradfordhill-Clinical Area ( Site 1070),Santiago,Region M. De Santiago,Chile,8420383[64]Oncocentro ( Site 1065),Vina del Mar,Valparaiso,Chile[65]Anhui Provincial Hospital-Obstetrics and Gynecology ( Site 4034),Hefei,Anhui,China,230001[66]Beijing Cancer Hospital ( Site 4048),Beijing,Beijing,China,100036[67]Peking Union Medical College Hospital ( Site 4036),Beijing,Beijing,China,100730[68]Chongqing Cancer Hospital ( Site 4040),Chongqing,Chongqing,China,400030[69]The First Affiliated Hospital of Xiamen University ( Site 4060),Xiamen,Fujian,China,361003[70]The First Affiliated Hospital ( Site 4043),Guangzhou,Guangdong,China,510080[71]Guangxi Medical University Affiliated Tumor Hospital ( Site 4049),Nanning,Guangxi,China,530021[72]Harbin Medical University Cancer Hospital ( Site 4033),Harbin,Heilongjiang,China,150081[73]Hubei Cancer Hospital ( Site 4059),Wuhan,Hubei,China,430079[74]Xiangya Hospital Central-South University ( Site 4035),Changsha,Hunan,China,410008[75]Hunan Cancer Hospital ( Site 4050),Changsha,Hunan,China,410013[76]Nanjing Drum Tower Hospital ( Site 4037),Nanjing,Jiangsu,China,210008[77]Jiangxi Maternal and Child Health Hospital ( Site 4051),Nanchang,Jiangxi,China,530021[78]The First Bethune Hospital of Jilin University ( Site 4057),Changchun,Jilin,China,130021[79]The First Affiliated Hospital of Xi an Jiaotong University ( Site 4045),XI An,Shaanxi,China,710061[80]Obstetrics and Gynecology Hosp. Fudan University ( Site 4041),Shanghai,Shanghai,China,200090[81]Shanghai Renji Hospital Affiliated to Jiao Tong University ( Site 4053),Shanghai,Shanghai,China,200127[82]Shanghai First Maternity and Infant Hospital-Gynecology department ( Site 4001),Shanghai,Shanghai,China,201204[83]Sichuan Cancer Hospital ( Site 4039),Chengdu,Sichuan,China,610041[84]Tianjin Medical University Cancer Institute & Hospital ( Site 4054),Tianjin,Tianjin,China,300060[85]Yunnan Province Cancer Hospital-Gynecology Department ( Site 4055),Kunming,Yunnan,China,650118[86]The First Affiliated Hospital, Zhejiang University-Gynecology ( Site 4002),Hangzhou,Zhejiang,China,310003[87]Women s Hospital School of Medicine Zhejiang University ( Site 4032),Hangzhou,Zhejiang,China,310006[88]The First Affiliated Hospital of Wenzhou Medical University ( Site 4056),Wenzhou,Zhejiang,China,325000[89]Clínica Vida Fundación - Sede Poblado ( Site 1096),Medellin,Antioquia,Colombia,050030[90]Instituto Nacional de Cancerología E.S.E ( Site 1094),Bogota,Distrito Capital De Bogota,Colombia,111511[91]Instituto Cancerologico de Narino Ltda ( Site 1092),San Juan De Pasto,Narino,Colombia,520002[92]Fundacion Valle del Lili ( Site 1093),Cali,Valle Del Cauca,Colombia,760032[93]Fakultní nemocnice Brno Bohunice-Gynekologicko-porodnicka klinika ( Site 2394),Brno,Brno-mesto,Czechia,62500[94]Fakultni nemocnice Kralovske Vinohrady ( Site 2393),Praha,Praha 10,Czechia,100 34[95]Vseobecna fakultni nemocnice v Praze ( Site 2391),Praha,Praha 2,Czechia,120 00[96]Fakultni nemocnice Olomouc ( Site 2392),Olomouc,Czechia,775 20[97]Rigshospitalet University Hospital ( Site 2515),Copehagen,Hovedstaden,Denmark,2100[98]Herlev Hospital ( Site 2514),Herlev,Hovedstaden,Denmark,2730[99]Aalborg Universitetshospital ( Site 2511),Aalborg,Nordjylland,Denmark,9100[100]Roskilde Sygehus ( Site 2513),Roskilde,Sjaelland,Denmark,4000[101]Odense Universitetshospital ( Site 2512),Odense,Syddanmark,Denmark,5000[102]Tampere University Hospital ( Site 2541),Tampere,Pirkanmaa,Finland,33520[103]Kuopio University Hospital ( Site 2543),Kuopio,Pohjois-Savo,Finland,70029[104]Turku University Hospital ( Site 2542),Turku,Varsinais-Suomi,Finland,20760[105]Institut De Cancerologie De Lorraine ( Site 2072),Vandoeuvre les Nancy,Ain,France,54519[106]Centre Antoine Lacassagne ( Site 2073),Nice,Alpes-Maritimes,France,06189[107]Centre Francois Baclesse ( Site 2062),Caen,Calvados,France,14076[108]Hôpital Privé Des Côtes d''Armor ( Site 2063),Plérin,Cotes-d Armor,France,22190[109]CHU Besancon - Hopital Jean Minjoz ( Site 2068),Besancon,Doubs,France,25000[110]Institut Bergonie ( Site 2067),Bordeaux,Gironde,France,33076[111]Institut Universitaire du Cancer Toulouse - Oncopole ( Site 2065),Toulouse,Haute-Garonne,France,31059[112]Institut Regional du Cancer de Montpellier - ICM ( Site 2069),Montpellier,Herault,France,34298[113]Hopital Cochin ( Site 2070),Paris,Ile-de-France,France,75014[114]Gustave Roussy ( Site 2071),Villejuif,Ile-de-France,France,94800[115]Hopital prive du Confluent ( Site 2061),Nantes,Loire-Atlantique,France,44277[116]Centre Hospitalier Lyon Sud ( Site 2064),Pierre Benite,Rhone,France,69310[117]SLK-Kliniken Heilbronn GmbH ( Site 2116),Heilbronn,Baden-Wurttemberg,Germany,74078[118]Klinikum Ludwigsburg ( Site 2111),Ludwigsburg,Baden-Wurttemberg,Germany,71640[119]Universitaetsklinikum Tuebingen ( Site 2113),Tübingen,Baden-Wurttemberg,Germany,72076[120]Medizinische Hochschule Hannover-Department of Obstetrics and Gynecology ( Site 2109),Hannover,Niedersachsen,Germany,30625[121]Universitätsklinikum Bonn-Gynaecological oncology ( Site 2103),Bonn,Nordrhein-Westfalen,Germany,53127[122]Kliniken Essen-Mitte, Evangelische Huyssens-Stiftung ( Site 2105),Essen,Nordrhein-Westfalen,Germany,45136[123]Universitaetsklinikum Carl Gustav Carus Dresden-Klinik und Poliklinik für Frauenheilkunde und Gebur,Dresden,Sachsen,Germany,01307[124]Universitätsklinikum Schleswig-Holstein ( Site 2101),Lübeck,Schleswig-Holstein,Germany,23538[125]General Hospital of Patras. St Andrews ( Site 2421),Patras,Achaia,Greece,263 32[126]Geniko Panepistimako Nosokomeio ARETEIO ( Site 2423),Athens,Attiki,Greece,115 28[127]Perifereiako Geniko Nosokomeio ALEXANDRA ( Site 2425),Athens,Attiki,Greece,115 28[128]Athens University Hospital ATTIKON ( Site 2424),Chaidari,Attiki,Greece,124 62[129]Hospital Hygeia ( Site 2426),Marousi,Attiki,Greece,151 23[130]Euromedica General Clinic of Thessaloniki ( Site 2422),Thessaloniki,Greece,546 45[131]Rambam Medical Center ( Site 2307),Haifa,Israel,3109601[132]Edith Wolfson Medical Center ( Site 2306),Holon,Israel,5822012[133]Hadassah Medical Center. Ein Kerem ( Site 2303),Jerusalem,Israel,9112001[134]Rabin Medical Center ( Site 2305),Petah Tikva,Israel,4941492[135]Chaim Sheba Medical Center ( Site 2301),Ramat Gan,Israel,5262000[136]Istittuto Nazionale dei Tumori Regina Elena IRCCS - IFO ( Site 2121),Roma,Abruzzo,Italy,00144[137]Fondazione Policlinico Universitario Agostino Gemelli ( Site 2124),Roma,Lazio,Italy,00168[138]Istituto di Candiolo - IRCCS ( Site 2125),Candiolo,Piemonte,Italy,10060[139]Azienda Ospedaliera Spedali Civili di Brescia ( Site 2135),Brescia,Italy,25123[140]IRCCS Ospedale San Raffaele ( Site 2130),Milano,Italy,20132[141]Fondazione IRCCS Istituto Nazionale dei Tumori di Milano ( Site 2122),Milano,Italy,20133[142]Istituto Europeo di Oncologia IRCCS-Divisione di Ginecologia Oncologica ( Site 2132),Milano,Italy,20141[143]Azienda Ospedaliera Universitaria Federico II ( Site 2123),Napoli,Italy,80131[144]Istituto Nazionale Tumori IRCCS Fondazione Pascale ( Site 2127),Napoli,Italy,80131[145]Istituto Oncologico Veneto IRCCS-Oncologia 2 ( Site 2134),Padova,Italy,35128[146]Aichi Cancer Center Hospital ( Site 4190),Nagoya,Aichi,Japan,464-8681[147]National Cancer Center Hospital East ( Site 4197),Kashiwa,Chiba,Japan,277-8577[148]National Hospital Organization Shikoku Cancer Center ( Site 4181),Matsuyama,Ehime,Japan,791-0280[149]Ehime University Hospital ( Site 4187),Toon,Ehime,Japan,7910295[150]Kurume University Hospital ( Site 4186),Kurume,Fukuoka,Japan,830-0011[151]Gunma Prefectural Cancer Center ( Site 4183),Ota,Gunma,Japan,373-8550[152]Hokkaido University Hospital ( Site 4194),Sapporo,Hokkaido,Japan,060-8648[153]Hyogo Cancer Center ( Site 4195),Akashi,Hyogo,Japan,673-8558[154]Iwate Medical University Hospital ( Site 4189),Shiwa-gun,Iwate,Japan,028-3695[155]University of the Ryukyus Hospital ( Site 4184),Nakagami-gun,Okinawa,Japan,903-0215[156]Saitama Medical University International Medical Center ( Site 4182),Hidaka,Saitama,Japan,350-1298[157]Shizuoka Cancer Center Hospital and Research Institute ( Site 4192),Sunto-gun,Shizuoka,Japan,411-8777[158]National Hospital Organization Kyushu Cancer Center ( Site 4193),Fukuoka,Japan,811-1395[159]Niigata Cancer Center Hospital ( Site 4185),Niigata,Japan,951-8566[160]Osaka International Cancer Institute ( Site 4188),Osaka,Japan,541-8567[161]The Cancer Institute Hospital of JFCR ( Site 4196),Tokyo,Japan,135-8550[162]Keio University Hospital ( Site 4191),Tokyo,Japan,160-8582[163]National Cancer Center ( Site 4065),Goyang-si,Kyonggi-do,Korea, Republic of,10408[164]Seoul National University Bundang Hospital ( Site 4063),Seongnam-si,Kyonggi-do,Korea, Republic of,13620[165]Severance Hospital Yonsei University Health System ( Site 4062),Seoul,Korea, Republic of,03722[166]Asan Medical Center ( Site 4061),Seoul,Korea, Republic of,05505[167]Samsung Medical Center ( Site 4064),Seoul,Korea, Republic of,06351[168]Investigacion Onco Farmaceutica S de RL de CV ( Site 1127),La Paz,Baja California Sur,Mexico,23040[169]Hospital San Lucas Cardiologica del Sureste ( Site 1122),Tuxtla Gutierrez,Chiapas,Mexico,29090[170]Instituto Nacional de Cancerologia ( Site 1124),Cdmx,Distrito Federal,Mexico,14080[171]Christus Muguerza Clinica Vidriera ( Site 1125),Monterrey,Nuevo Leon,Mexico,64570[172]I Can Oncology Center SA de CV ( Site 1126),Monterrey,Nuevo Leon,Mexico,64710[173]Hospital Angeles Roma ( Site 1123),Ciudad de Mexico,Mexico,06700[174]Centro Oncologico Internacional. SEDNA ( Site 1121),Mexico City,Mexico,04700[175]University Hospital of North Norway ( Site 2153),Tromso,Troms,Norway,9019[176]Soerlandet sykehus HF Kristiansand ( Site 2152),Kristiansand,Vest-Agder,Norway,4615[177]Oslo Universitetssykehus Radiumhospitalet ( Site 2151),Oslo,Norway,0379[178]Mazowiecki Szpital Wojewódzki w Siedlcach-Siedleckie Centrum Onkologii ( Site 2487),Siedlce,Mazowieckie,Poland,08-110[179]Szpital Kliniczny im Ks Anny Mazowieckiej ( Site 2481),Warszawa,Mazowieckie,Poland,00-315[180]Bialostockie Centrum Onkologii ( Site 2483),Bialystok,Podlaskie,Poland,15-027[181]Narodowy Instytut Onkologii - Oddzial w Gliwicach ( Site 2482),Gliwice,Slaskie,Poland,44101[182]Swietokrzyskie Centrum Onkologii SPZOZ ( Site 2485),Kielce,Swietokrzyskie,Poland,25-734[183]SPZOZ MSWIA z Warminsko-Mazurskim Centrum Onkologii w Olsztynie ( Site 2486),Olsztyn,Warminsko-mazurskie,Poland,10-228[184]Wielkopolskie Centrum Onkologii im.M.Sklodowskiej-Curie ( Site 2484),Poznan,Wielkopolskie,Poland,61-866[185]Arkhangelsk Clinical Oncological Dispensary ( Site 2637),Arkhangelsk,Arkhangel Skaya Oblast,Russian Federation,163045[186]Republican Clinical Oncology Dispensary of Republic of Bashkortostan ( Site 2645),Ufa,Baskortostan, Respublika,Russian Federation,450054[187]Chelyabinsk Regional Clinical Center Oncology and Nuclear Medicine ( Site 2644),Chelyabinsk,Chelyabinskaya Oblast,Russian Federation,454087[188]Krasnoyarsk Regional Clinical oncology dispensary ( Site 2643),Krasnoyarsk,Krasnoyarskiy Kray,Russian Federation,660133[189]National Research Ogarev Mordovia State University ( Site 2648),Saransk,Mordoviya, Respublika,Russian Federation,430032[190]FSBI National Medical Oncology Research Center n.a. N.N. Blokhina ( Site 2634),Moscow,Moskva,Russian Federation,115478[191]Moscow Research Oncology Institute named after P.A. Hertsen ( Site 2631),Moscow,Moskva,Russian Federation,125284[192]Nizhegorodsky Regional Oncology Dispensary-chemotherapy department (Branch№1) ( Site 2639),Nizhniy Novgorod,Nizhegorodskaya Oblast,Russian Federation,603126[193]Samara Regional Clinical Oncology Center-Chemotherapy Dapartment ( Site 2649),Samara,Samarskaya Oblast,Russian Federation,443031[194]Scientific Research Oncology Institute n.a. N.N.Petrov ( Site 2636),Saint-Petersburg,Sankt-Peterburg,Russian Federation,197758[195]Republican Clinical Oncology Dispensary of Tatarstan MoH ( Site 2646),Kazan,Tatarstan, Respublika,Russian Federation,420029[196]Tomsk Scientific Research Institute of Oncology-Chemotherapy ( Site 2638),Tomsk,Tomskaya Oblast,Russian Federation,634028[197]Yaroslavl Regional SBIH Clinical Oncology Hospital ( Site 2641),Yaroslavl,Yaroslavskaya Oblast,Russian Federation,150054[198]Hospital Josep Trueta ( Site 2184),Girona,Gerona,Spain,17007[199]Clinica Universitaria de Navarra ( Site 2181),Madrid,Madrid, Comunidad De,Spain,28027[200]Hospital Vall D Hebron ( Site 2182),Barcelona,Spain,08035[201]Hospital Clinic i Provincial ( Site 2185),Barcelona,Spain,08036[202]Hospital Universitario Reina Sofia ( Site 2183),Cordoba,Spain,14004[203]Hospital Clinico San Carlos ( Site 2187),Madrid,Spain,28040[204]Hospital Universitario La Paz ( Site 2186),Madrid,Spain,28046[205]Universitetssjukhuset i Linkoping. ( Site 2222),Linkoping,Ostergotlands Lan,Sweden,581 85[206]Karolinska Universitetssjukhuset Solna ( Site 2220),Solna,Stockholms Lan,Sweden,171 76[207]Blod-och Tumorsjukdomar ( Site 2221),Uppsala,Uppsala Lan,Sweden,751 85[208]Changhua Christian Hospital ( Site 4095),Changhua,Taiwan,50006[209]Taichung Veterans General Hospital ( Site 4094),Taichung,Taiwan,40705[210]MacKay Memorial Hospital ( Site 4092),Taipei,Taiwan,10449[211]Taipei Veterans General Hospital ( Site 4093),Taipei,Taiwan,11217[212]Linkou Chang Gung Memorial Hospital ( Site 4091),Taoyuan,Taiwan,333[213]Baskent Adana Dr Turgut Noyan Uygulama ve Arastirma Merkezi ( Site 2355),Adana,Turkey,01250[214]Cukurova Uni. Tip Fakultesi ( Site 2353),Adana,Turkey,01330[215]Baskent Universitesi Ankara Hastanesi ( Site 2354),Ankara,Turkey,06490[216]Ankara Universitesi Tıp Fakultesi Hastanesi ( Site 2350),Ankara,Turkey,06590[217]Medipol Universite Hastanesi ( Site 2352),Istanbul,Turkey,34214[218]Ege University Medical Faculty ( Site 2351),Izmir,Turkey,35100[219]I.E.U. Medical Point Hastanesi ( Site 2356),Izmir,Turkey,35575[220]Chernihiv Medical Center of Modern Oncology ( Site 2368),Chernihiv,Chernihivska Oblast,Ukraine,14029[221]"Municipal Enterprise ""Bukovinian сlinical oncology сenter"" ( Site 2366),Chernivtsi,Chernivetska Oblast,Ukraine,58000[222]"
SO Grigoriev Institute for Medical Radiology and Oncology of NAMS of Ukraine ( Site 2363),Kharkiv,Kharkivska Oblast,Ukraine,61024[223]"MNE ""Khmelnytskyi regional antitumor center"" ( Site 2365),Khmelnitskyi,Khmelnytska Oblast,Ukraine,29009[224]"
LISOD - Israeli Oncological Hospital MedX-ray International Group, LLC ( Site 2364),Kiev,Kyivska Oblast,Ukraine,08720[225]Lviv State Regional Oncological Center ( Site 2361),Lviv,Lvivska Oblast,Ukraine,79031[226]The Municipal Enterprise Volyn Regional Medical Oncology Centre ( Site 2362),Lutsk,Volynska Oblast,Ukraine,43018[227]Bristol Haematology and Oncology Centre ( Site 2244),Bristol,Bristol, City Of,United Kingdom,BS2 8ED[228]Castle Hill Hospital-Academic Oncology ( Site 2252),Cottingham,East Riding Of Yorkshire,United Kingdom,HU165JQ[229]Beatson West of Scotland Cancer Centre ( Site 2247),Glasgow,Glasgow City,United Kingdom,G12 0YN[230]UCLH NHS Foundation Trust ( Site 2242),London,London, City Of,United Kingdom,NW1 2PG[231]Royal Marsden NHS Foundation Trust ( Site 2248),London,London, City Of,United Kingdom,SW3 6JJ[232]Royal Marsden Hospital Sutton-Surrey ( Site 2241),Sutton,London, City Of,United Kingdom,SM25PT[233]Leicester Royal Infirmary. Univ. Hosp. of Leicester NHS Trust ( Site 2249),Leicester,United Kingdom[234]The Christie Hospital NHS Foundation Trust ( Site 2243),Manchester,United Kingdom,M20 4BX
The purpose of this study is to compare pembrolizumab + adjuvant chemotherapy with placebo + adjuvant chemotherapy, with or without radiotherapy, with respect to disease-free survival (DFS) as assessed radiographically by the investigator or by histopathologic confirmation of suspected disease recurrence, and with respect to overall survival (OS). The primary hypotheses are that pembrolizumab + adjuvant chemotherapy is superior to placebo + adjuvant chemotherapy, with or without radiotherapy, with respect to DFS as assessed radiographically by the investigator or by histopathologic confirmation of suspected disease recurrence, and with respect to OS.
