研究单位：[1]Taizhou Hanzhong biomedical co. LTD[2]Anhui Provincial Cancer Hospital,Hefei,Anhui,China,230000[3]Anhui Provincial Hospital,Hefei,Anhui,China,230001[4]The Second Affiliated Hospital of Anhui Medical University,Hefei,Anhui,China,230601[5]Beijing ChaoYang Hospital, Capital Medical University,Beijing,Beijing,China,100020[6]Cancer Hospital, Chinese Academy of Medical Sciences,Beijing,Beijing,China,100021[7]Peking Union Medical College Hospital,Beijing,Beijing,China,100032[8]Beijing Friendship Hospital, Capital Medical University,Beijing,Beijing,China,100050[9]Peking University Third Hospital,Beijing,Beijing,China,100191[10]Peking University Internationale Hospital,Beijing,Beijing,China,102206[11]Chongqing University Cancer Hospital,Chongqing,Chongqing,China,400030[12]Fujian Cancer Hospital,Xiamen,Fujian,China,350000[13]Gansu Wuwei Tumor Hospital,Wuwei,Gansu,China,350000[14]Affiliated Cancer Hospital of Guangzhou Medical University,Guangzhou,Guangdong,China,510095[15]Zhongshan People's Hospital,Guangzhou,Guangdong,China,528403[16]Peking University Shenzhen Hospital,Shenzhen,Guangdong,China,518035[17]Cancer Hospital Chinese Academy of Medical Sciences, Shenzhen Center,Shenzhen,Guangdong,China,518117[18]Guangxi Medical University Cancer Hospital,Naning,Guangxi,China,530021[19]The First Affiliated Hospital, Sun Yat-sen University,Guangzhou,Guangzhou,China,510080[20]The Fourth Hospital of Hebei Medical University,Shijiazhuang,Hebei,China,050011[21]The First Hospital of Hebei Medical University,Shijiazhuang,Hebei,China,050051[22]Affiliated Hospital of Hebei University,Shijiazhuang,Hebei,China,071000[23]The affiliated Cancer Hospital of Harbin Medical University,Harbin,Heilongjiang,China,150081[24]Henan Cancer Hospital,Zhengzhou,Henan,China,450008[25]The First Affiliated Hospital of Zhengzhou University,Zhengzhou,Henan,China,450052[26]The First Affiliated Hospital of Henan Science&Technology University,Zhengzhou,Henan,China,471000[27]Henan Provincial People''s Hospital,Zhengzhou,Henan,China,540003[28]The Second Xiangya Hospital of Cancer South University,Changsha,Hunan,China,410000[29]Xiangya Hospital, Central South University,Changsha,Hunan,China,410000[30]Hunan Cancer Hospital,Changsha,Hunan,China,410200[31]The Affiliated People''s Hospital of Inner Mongolia Medical University,Huhhot,Inner Mongolia,China,010000[32]Changzhou Cancer Hospital,Changzhou,Jiangsu,China,213000[33]Jiangsu Provincial Hospital,Nanjing,Jiangsu,China,210000[34]Nanjing Drum Tower Hospital,Nanjing,Jiangsu,China,210009[35]Zhongda Hospital Southeast Universtiy,Nanjing,Jiangsu,China,210009[36]Nantong Tumor Hospital,Nantong,Jiangsu,China,226006[37]The Second Affiliated Hospital of Soochow University,Suzhou,Jiangsu,China,215000[38]Xuzhou Central Hospital,Xuzhou,Jiangsu,China,221009[39]Yangzhou FIrst People''s Hospital,Yangzhou,Jiangsu,China,225000[40]The First Affiliated Hospital of Nanchang University,Nanchang,Jiangxi,China,330006[41]Jiangxi Cancer Hospital,Nanchang,Jiangxi,China,330029[42]Jilin Cancer Hospital,Changchun,Jilin,China,130000[43]The First Hospital of Jilin University,Changchun,Jilin,China,130000[44]The First Hospital of China Medical University,Shenyang,Liaoning,China,110001[45]Liaoning Cancer Hospital,Shenyang,Liaoning,China,110042[46]General Hospital of Ningxia Medical University,Yinchuan,Ningxia,China,750001[47]Shandong Provincial Hospital,Jinan,Shandong,China,250000[48]Shandong Cancer Hospital,Jinan,Shandong,China,250117[49]The Affiliated Hospital of Qingdao University,Qingdao,Shandong,China,266000[50]Yantai Yuhuangding Hospital,Yantai,Shandong,China,264000[51]Shanghai General Hospital,Shanghai,Shanghai,China,200000[52]Shanghai Sixth People''s Hospital,Shanghai,Shanghai,China,200233[53]Shanxi Cancer Hospital,Taiyuan,Shanxi,China,030013[54]The First Affiliated Hospital of Xi''an Jiaotong University,Xi''an,Shanxi,China,710061[55]Sichuan Cancer Hospital,Chengdu,Sichuan,China,610041[56]Tianjin Medical University General Hospital,Tianjin,
研究目的：
This is a randomized, double-blinded, multicenter study to evaluate the efficacy and safety of HX008 injection combined with irinotecan versus placebo combined with irinotecan as second-line therapy in patients with adcanced gastric or gastroesophageal junction (GEJ) adenocarcinoma who have had tumor progression after first-line treatment with platinum and/or fluropyrimidine therapy.
