Phase 3 Study of Pyrotinib Versus Docetaxel in Patients With Advanced Non-squamous NSCLC Harboring a HER2 Exon 20 Mutation Who Failed Platinum Based Chemotherapy
研究单位：[1]Jiangsu HengRui Medicine Co., Ltd.[2]University of California - Irvine Medical Center,Orange,California,United States,92868[3]University of California (UC) Davis Comprehensive Cancer Center,Sacramento,California,United States,95817[4]Innovative Clinical Research Institute,Whittier,California,United States,33756[5]Florida Cancer Specialists South Divisio,Fort Myers,Florida,United States,33901[6]Florida Cancer Specialists North Divisio,Saint Petersburg,Florida,United States,33701[7]University of Kansas Medical Center (KUMC),Kansas City,Kansas,United States,66160[8]David H. Koch Center for Cancer Care at Memorial Sloan Kettering Cancer Center,New York,New York,United States,10021[9]Gabrail Cancer Center,Canton,Ohio,United States,44718[10]Tennessee Oncology,Nashville,Tennessee,United States,33756[11]MD Anderson Cancer Center,Houston,Texas,United States,77030[12]Summit Cancer Centers - North Spokane,Spokane,Washington,United States,99208[13]Royal North Shore Hospital,St Leonards,Saint Leonards,Australia[14]Border Medical Oncology,Albury,Australia[15]St Vincent's Hospital Melbourne,Fitzroy,Australia[16]Sir Charles Gairdner Hospital,Nedlands,Australia[17]Calvary North Adelaide Hospital,North Adelaide,Australia[18]Antwerp University Hospital (UZA),Edegem,Belgium[19]University Hospital Gent,Gent,Belgium[20]University Hospital (UZ) Leuven,Leuven,Belgium[21]the Second Affiliated Hospital of Anhui Medical University,Hefei,Anhui,China[22]beijing chest hospital,Capital medical university,Beijing,Beijing,China[23]Peking university Cancer Hospital,Beijing,Beijing,China[24]The second affiliated hospital of ChongQing medical university,Chongqing,Chongqing,China[25]The First Affiliated Hospital of Guangdong Pharmaceutical University,Guangzhou,Guangdong,China[26]Cangzhou Hospital of Integrated Tcm-Wm.Hebei,Cangzhou,Hebei,China[27]Harbin Medical University Cancer Hospital,Ha''erbin,Heilongjiang,China[28]First Affiliated Hospital of ZhengzhouUniversity,Zhengzhou,Henan,China[29]Henan Cancer Hospital,Zhengzhou,Henan,China[30]Hubei cancer hospital WardII,Wuhan,Hubei,China[31]Hunan Cancer Hospital & The Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University,Changsha,Hunan,China[32]Jiangsu Cancer Hospital,Nanjing,Jiangsu,China[33]Subei People''s Hospital of Jiangsu Province,Yangzhou,Jiangsu,China[34]The Second Affiliated of Nanchang University,Nanchang,Jiangxi,China[35]Jilin Cancer Hospital,Changchun,Jilin,China[36]The affiliated hospital of inner mongolia medical univerity,Hohhot,Neimenggu,China[37]Shandong Cancer Hospital Affiliated to Shandong University,Jinan,Shandong,China[38]Shanghai Pulmonary Hospital, Tongji University,Shanghai,Shanghai,China,200433[39]Fudan University Cancer hospital,Shanghai,Shanghai,China[40]Ruijin Hospital, Shanghai Jiaotong University School of Medicine,Shanghai,Shanghai,China[41]Shanghai Chest Hospital,Shanghai,Shanghai,China[42]Shanxi Provincial Cancer Hospital,Taiyuan,Shanxi,China[43]SiChuan Cancer Hospital,Chengdu,Sichuan,China[44]West China Hospital,Sichuan University,Chengdu,Sichuan,China[45]The Second People''s Hosipital of Yibin,Yibin,Sichuan,China[46]General Hospital of Tianjin Medical University,Tianjin,Tianjin,China[47]Yunnan Provincial Cancer Hospital,Kunming,Yunnan,China[48]Sir Run Run Shaw Hospital ZheJiang University School Of Medicine,Hangzhou,Zhejiang,China[49]The First Affiliated Hospital，ZheJiang University,Hangzhou,Zhejiang,China[50]ZheJiang Cancer Hospital,Hangzhou,Zhejiang,China[51]Taizhou Hospital of Zhejiang Province,Taizhou,Zhejiang,China[52]Centre Francois Baclesse,CAEN cedex 05,France[53]Centre Hospitalier Intercommunal Creteil,Creteil,France[54]AP-HM - Hôpital Nord,Marseille cedex 20,France[55]Hopital Bichat - Claude Bernard - AP-HP,Paris,France[56]CHRU Strasbourg,Strasbourg Cedex,France[57]CHU Toulouse - Hopital Larrey,Toulouse,France
This is a randomized, positive-controlled, open-label, international multicenter, Phase 3 clinical study to compare the efficacy and safety of pyrotinib versus docetaxel in patients with advanced non-squamous NSCLC harboring a HER2 exon 20 mutation who failed platinum based chemotherapy.
