研究单位：[1]Incyte Corporation[2]Mayo Clinic Arizona,Phoenix,Arizona,United States,85054[3]Marin Cancer Care,Greenbrae,California,United States,94904[4]Georgetown University - Lombardi Comprehensive Cancer Center,Washington,District of Columbia,United States,20007[5]Mayo Clinic - Florida,Jacksonville,Florida,United States,32224[6]Mount Sinai Medical Center Comprehensive Cancer Center,Miami Beach,Florida,United States,33140[7]Winship Cancer Institute of Emory University,Atlanta,Georgia,United States,30322[8]University of Chicago Medical Center,Chicago,Illinois,United States,60637-1447[9]Parkview Research Center,Fort Wayne,Indiana,United States,46845[10]University of Iowa Hospital and Clinics,Iowa City,Iowa,United States,52242[11]The University of Kansas Cancer Center,Westwood,Kansas,United States,66205[12]Ochsner Clinic Foundation Ocf Ochsner Cancer Institute Oci,New Orleans,Louisiana,United States,70121[13]Johns Hopkins Oncology Center,Baltimore,Maryland,United States,21287[14]Boston Medical Center,Boston,Massachusetts,United States,02118[15]Beth Israel Deaconess Medical Center,Boston,Massachusetts,United States,02215[16]Barbara Ann Karmanos Cancer Hospital,Detroit,Michigan,United States,48201[17]Henry Ford Hospital,Detroit,Michigan,United States,48202[18]Karmanos Cancer Institute,Farmington Hills,Michigan,United States,48334[19]Mayo Clinic,Rochester,Minnesota,United States,55905[20]Comprehensive Cancer Centers of Nevada - Twain,Las Vegas,Nevada,United States,89169[21]Summit Medical Group,Florham Park,New Jersey,United States,07932[22]Icahn School of Medicine At Mount Sinai,New York,New York,United States,10029[23]White Plains Hospital,White Plains,New York,United States,10601[24]University Hospitals Cleveland Medical Center,Cleveland,Ohio,United States,44106[25]Cleveland Clinic Foundation,Cleveland,Ohio,United States,44195[26]Providence Portland Med. Ctr,Portland,Oregon,United States,97213[27]Oregon Health & Science University,Portland,Oregon,United States,97239[28]Fox Chase Cancer Center,Philadelphia,Pennsylvania,United States,19111[29]Greenville Hospital System University Medical Center Institute For Translational Oncology Research,Greenville,South Carolina,United States,29605[30]Baylor Scott and White Research Institute,Dallas,Texas,United States,75246[31]Houston Methodist Research Institute,Houston,Texas,United States,77030[32]Riverside Regional Medical Center,Newport News,Virginia,United States,23601[33]Virginia Mason Medical Center,Seattle,Washington,United States,98101[34]West Virginia University Cancer Institute,Morgantown,West Virginia,United States,26506[35]Aurora Research Institute,Wauwatosa,Wisconsin,United States,53226[36]Landeskrankenhaus Universitatsklinikum Graz,Graz,Austria,08036[37]Innsbruck University Hospital,Innsbruck,Austria,A-6020[38]Ordensklinikum Krankenhaus Der Barmherzigen Schwestern Linz,Linz,Austria,04010[39]Salzburger Universitatsklinikum,Salzburg,Austria,05020[40]Landeskrankenhaus Steyr,Steyr,Austria,04400[41]Allgemeines Krankenhaus Der Stadt Wien,Vienna,Austria,01090[42]Ulb Hospital Erasme,Bruxelles,Belgium,01070[43]Universitair Ziekenhuis Brussel,Bruxelles,Belgium,01090[44]Universitair Ziekenhuis Gent,Gent,Belgium,09000[45]Hospital de Jolimont,Haine-st-paul,Belgium,07100[46]Az Groeninge Campus Kennedylaan,Kortrijk,Belgium,08500[47]Universitaire Ziekenhuis Leuven - Gasthuisberg,Leuven,Belgium,03000[48]Chu Ucl Namur University Hospital Mont-Godinne,Yvoir,Belgium,05530[49]University of Calgary - Cumming School of Medicine,Calgary,Alberta,Canada,T2N 4N1[50]Cancercare Manitoba,Winnipeg,Manitoba,Canada,R3E 0V9[51]Nova Scotia Health Authority/Qeii Health Sciences Centre,Halifax,Nova Scotia,Canada,B3H 4K4[52]Princess Margaret Cancer Center,Toronto,Ontario,Canada,MG5 2M9[53]Peking Union Medical College Hospital,Beijing,China,100032[54]West China Hospital Sichuan University,Chengdu,China,610041[55]Fujian Cancer Hospital,Fuzhou,China,350005[56]Sun Yat-Sen Memorial Hospital Sun Yat-Sen University,Guangdong,China,510000[57]Sun Yat-Sen Memorial Hospital Sun Yat-Sen University,Guangzhou,China,510000[58]Shulan Hangzhou Hospital Co Ltd,Hangzhou,China,310000[59]The Second Affiliated Hospital of Zhejiang University School of Medicine,Hangzhou,China,310009[60]Heilongjiang Province Cancer Hospital,Harbin,China,150081[61]University of Science and Technology of China-First Affiliated Hospital (Anhui Provincial Hospital),Hefei,China,230001[62]Kunming 1St People'S Hospital,Kunming,China,650032[63]Jiangsu Province Hospital,Nanjing,China,210029[64]The Affiliated Hospital of Qingdao University,Shandong,China,266071[65]Zhongshan Hospital Fudan University,Shanghai,China,200032[66]Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine,Shanghai,China,200092[67]Xinhua Hospital,SHanghai,China,200092[68]Sichuan Cancer Hospital,Sichuan,China,610041[69]Tianjin Medical University Cancer Institute Hospital,Tianjin,China,300060[70]Tongji Hospital Huazhong University of Science and Technology,Wuhan,China,430030[71]Hubei Cancer Hospital,Wuhan,China,430079[72]Northern Jiangsu Peoples Hospital,Yangzhou,China,225001[73]Herlev Og Gentofte Hospital,Herlev,Denmark,02730[74]Docrates Cancer Center,Helsinki,Finland,00180[75]Helsinki University Central Hospital,Helsinki,Finland,00290[76]Tampere University Hospital,Tampere,Finland,33521[77]Institut Sainte Catherine,Avignon Cedex 9,France,84918[78]Chu Besancon Hospital Jean Minjoz,Besancon,France,25030[79]Institut Bergonie,Bordeaux Cedex,France,33076[80]Hopital Beaujon,Clichy,France,92110[81]Hopital Prive Jean Mermoz,Lyon Cedex 08,France,69373[82]Chu Hopital de La Timone,Marseille Cedex 5,France,13385[83]Centre Hospitalier Universitaire de Nantes,Nantes,France,44000[84]Centre Antoine Lacassagne,Nice Cedex 02,France,06189[85]Hospital Universitaire Pitie-Salpetriere,Paris Cedex 13,France,75013[86]Hopital Europeen Georges Pompidou (Hegp),Paris Cedex 15,France,75015[87]Centre Hospitalier Universitaire de Bordeaux - Hospital Haut-Leveque,Pessac Cedex,France,336600[88]Hospital de La Miletrie,Poitiers Cedex,France,86021[89]Hopital Charles Nicolle Chu Rouen Hospital de Bois-Guillaume,Rouen Cedex,France,76031[90]University Hospital of Saint Etienne,Saint Etienne,France,42055[91]Centre de Lutte Contre Le Cancer - Institut de Cancerologie de L''Ouest - Rene Gauducheau,Saint Herblain,France,44800[92]Chu Toulouse Hopital Rangueil,Toulouse Cedex 9,France,31059[93]Chu Vandoeuvre-Les-Nancy Hopital Brabois,Vandoeuvre Les Nancy,France,54511[94]Institut Gustave Roussy,Villejuif Cedex,France,94805[95]University Medical Center Rwth Aachen,Aachen,Germany,52074[96]Charite - Campus Virchow-Klinikum,Berlin,Germany,13353[97]Charite Universitaetsmedizin Berlin - Campus Charite Mitte,Berlin,Germany,13353[98]Universitatsklinikum Bonn Aoer,Bonn,Germany,53127[99]Klinikum Bremen-Nord,Bremen,Germany,28755[100]University Clinic Carl Gustav Carus Technical University Dresden,Dresden,Germany,01307[101]Klinikum Der Johann Wolfgang Goethe University,Frankfurt,Germany,60590[102]University Medical Center Freiburg,Freiburg,Germany,79106[103]Universitatsklinikum Hamburg Eppendorf,Hamburg,Germany,20246[104]Asklepios Klinik Altona,Hamburg,Germany,22763[105]Hannover Medical School,Hannover,Germany,30625[106]Universitaetsklinikum Des Saarlandes,Homburg / Saar,Germany,66421[107]Universitatsklinikum Koln,Koln,Germany,50937[108]Universitatsklinikum Leipzig Aor,Leipzig,Germany,04103[109]Klinikum Ludwigsburg,Ludwigsburg,Germany,71640[110]OTTO-VON-GUERICKE-UNIVERSIT�T MAGDEBURG,Magdeburg,Germany,39120[111]Universitatsmedizin Der Johannes Gutenberg-Universitat Mainz Iii,Mainz,Germany,55131[112]University Hospital Grosshadern Munich,Munich,Germany,81377[113]Klinikum Nuernberg,Nuernberg,Germany,90419[114]Universitaetsklinikum in Tubingen,Tubingen,Germany,72076[115]University Hospital Tuebingen,Tubingen,Germany,72076[116]UNIVERSIT�TSKLINIKUM ULM,ULM,Germany,89081[117]St. Vincent''S University Hospital,Dublin 4,Ireland,D04 Y8V0[118]Soroka University Medical Center,Beer-sheva,Israel,84001[119]Rambam Health Care Campus,Haifa,Israel,3109601[120]Hadassah University Hospital,Jerusalem,Israel,9112001[121]Rabin Medical Center - Beilinson Hospital,Petach Tikva,Israel,4941492[122]Tel Aviv Sourasky Medical Center,Tel Aviv,Israel,64239[123]Azienda Ospedaliero Universitaria Ospedali Riuniti,Ancona,Italy,60126[124]Istituto Tumori Giovanni Paolo Ii Irccs Ospedale Oncologico Bari,Bari,Italy,70124[125]Ospedale Papa Giovanni Xxiii,Bergamo,Italy,24127[126]L AZIENDA OSPEDALIERO-UNIVERSITARIA DI BOLOGNA POLICLINICO S. ORSOLA � MALPIGHI,Bologna,Italy,40138[127]Fondazione Del Piemonte Per L''Oncologia Ircc Candiolo,Candiolo,Italy,10060[128]Presidio Ospedaliero Garibaldi Nesima,Catania,Italy,95100[129]Ospedale Degli Infermi - Faenza,Faenza,Italy,48018[130]Irccs Azienda Ospedaliera Universitaria San Martino,Genova,Italy,16132[131]Comitato Etico Fondazione Irccs Istituto Nazionale Dei Tumori,Milano,Italy,20133[132]Istituto Di Ricovero E Cura A Carattere Scientifico (Irccs) Ospedale San Raffaele,Milan,Italy,20132[133]European Institute of Oncology,Milan,Italy,20141[134]Azienda Socio Sanitaria Territoriale Grande Ospedale Metropolitano Niguarda,Milan,Italy,20162[135]A.O.U. Di Modena - Policlinico,Modena,Italy,41124[136]Istituto Nazionale Tumori Irccs Fondazione Pascale,Napoli,Italy,80131[137]Universita Degli Studi Della Campania Luigi Vanvitelli U.O.C. Oncologia Medica,Napoli,Italy,80138[138]Azienda Ospedaliera Universitaria San Luigi Gonzaga Orbassano,Orbassano,Italy,10043[139]Iov - Istituto Oncologico Veneto Irccs,Padova,Italy,35128[140]Presidio Ospedaliero Pescara,Pescara,Italy,65124[141]Azienda Ospedaliera Universitaria Pisana,Pisa,Italy,56126[142]Fondazione Policlinico Universitario Agostino Gemelli Irccs,Roma,Italy,00137[143]Istituto Nazionale Tumori Regina Elena Irccs,Roma,Italy,00144[144]Universita Campus Bio Medico Di Roma,Rome,Italy,00128[145]Azienda Ospedaliera San Camillo Forlanini,Rome,Italy,00152[146]Irccs Istituto Clinico Humanitas,Rozzano,Italy,20089[147]Azienda Ospedaliera Universitaria Senese Policlinico Santa Maria Alle Scotte,Siena,Italy,53100[148]Centro Ricerche Cliniche Di Verona (Crc),Verona,Italy,37134[149]San Bartolo Hospital,Vicenza,Italy,36100[150]Aichi Cancer Center Hospital,Aichi,Japan,464 8681[151]University of Tokyo Hospital,Bunkyo,Japan,113-8655[152]Chiba University Hospital,Chiba,Japan,260-8677[153]Chiba Cancer Center,Chiba,Japan,260-8717[154]National Hospital Organization Kyushu Cancer Center,Fukuoka-shi,Japan,812-8582[155]National Hospital Organization Kyushu Cancer Center,Fukuoka,Japan,811-1395[156]Hiroshima University Hospital,Hiroshima-shi,Japan,734-8551[157]Hokkaido University Hospital,Hokkaido,Japan,060-8648[158]Hyogo College of Medicine Hospital,Hyogo,Japan,663-8501[159]Kanazawa University Hospital,Ishikawa,Japan,920-8641[160]Teikyo University Hospital,Itabashi-ku,Japan,173-8606[161]Kobe University Hospital,Kobe,Japan,650-0017[162]Cancer Institute Hospital of Jfcr,Koto-ku,Japan,135-8550[163]Kyoto University Hospital,Kyoto-shi,Japan,606-8507[164]Nho Shikoku Cancer Center,Matsuyama,Japan,791-0280[165]Kyorin University Hospital,Mitaka,Japan,181-8611[166]Niigata Cancer Center Hospital,Niigata,Japan,951-8566[167]Osaka International Cancer Institute,Osaka-shi,Japan,541-8567[168]Kindai University Hospital,Osakasayama City,Japan,589-8511[169]Saitama Cancer Center,Saitama,Japan,362-0806[170]Tohoku University Hospital,Sendai-shi,Japan,980-8574[171]Keio University Hospital,Shinjuku-ku,Japan,160-8582[172]Shizuoka Cancer Center,Shizuoka,Japan,411-8777[173]Osaka University Hospital,Suita-shi,Japan,565-0871[174]Jichi Medical University Hospital,Tochigi,Japan,329-0498[175]Toyama University Hospital,Toyama,Japan,930-0194[176]Yamaguchi University Hospital,UBE,Japan,755-8505[177]Wakayama Medical University Hospital,Wakayama,Japan,641-8509[178]Kanagawa Cancer Center,Yokohama-shi,Japan,241-8515[179]Yokohama City University Medical Center,Yokohama,Japan,232-0024[180]Oita University Hospital,Yufu-shi,Japan,879-5593[181]Amsterdam University Medical Centre,Amsterdam,Netherlands,1100 DD[182]Maastricht Umc+,Maastricht,Netherlands,6202 AZ[183]Erasmus Medical Center,Rotterdam,Netherlands,3015 CE[184]Umc Utrecht,Utrecht,Netherlands,3584 CX[185]Oslo University Hospital,Oslo,Norway,00450[186]Hospital de La Santa Creu I Sant Pau,Barcelona,Spain,08026[187]Hospital General Universitario Vall D Hebron,Barcelona,Spain,08035[188]Hospital Clinic I Provincial,Barcelona,Spain,08036[189]Hospital Clinic de Barcelona,Barcelona,Spain,8036[190]Hospital Universitario Reina Sofia,Cordoba,Spain,14004[191]Hospital Universitario Reina Sofia,Córdoba,Spain,14004[192]Hospital Materno Teresa Herrera,la Coruna,Spain,15006[193]Hospital General Universitario Gregorio Maranon,Madrid,Spain,28007[194]Hospital Universitario Ramon Y Cajal,Madrid,Spain,28034[195]Hospital Universitario Hm Sanchinarro,Madrid,Spain,28050[196]Hospital Regional Universitario de Malaga,Malaga,Spain,29010[197]Clinica Universidad de Navarra (Cun),Pamplona,Spain,31008[198]Hospital Universitari Parc Tauli,Sabadell,Spain,08208[199]HOSPITAL UNiVERSITARIO DONOSTIA,San Sebastian,Spain,20014[200]Hospital Universitario Marques de Valdecilla,Santander,Spain,39008[201]Hospital General Universitario de Valencia,Valencia,Spain,46014[202]Karolinska Institute Universitetssjukhuset Solna,Solna,Sweden,171 64[203]Inselspital - Universitaetsspital Bern,Bern,Switzerland,03010[204]Universitatsspital Zurich,Zuerich,Switzerland,08091[205]Aberdeen Royal Infirmary,Aberdeen,United Kingdom,AB25 2ZN[206]Addenbrooke''S Hospital,Cambridge,United Kingdom,CB2 0QQ[207]Velindre Cancer Centre,Cardiff,United Kingdom,CF14 2TL[208]University Hospital Coventry and Warwickshire,Coventry,United Kingdom,CV2 2DX[209]The Royal Marsden Nhs Foundation Trust - Chelsea,London,United Kingdom,SW3 6JJ[210]Imperial College Healthcare Nhs Trust - Hammersmith Hospital,London,United Kingdom,W12 0HS[211]University College London Hospitals (Uclh),London,United Kingdom,WC1E 6BT[212]Kent Oncology Centre - Maidstone Hospital,Maidstone,United Kingdom,ME16 9QQ[213]The Christie Nhs Foundation Trust,Manchester,United Kingdom,M20 4BV[214]The Royal Marsden Nhs Foundation Trust - Sutton,Sutton,United Kingdom,SM2 5PT
The purpose of this study is to evaluate the efficacy and safety of pemigatinib versus gemcitabine plus cisplatin chemotherapy in first-line treatment of participants with unresectable or metastatic cholangiocarcinoma with FGFR2 rearrangement.
