Cancer is a fatal disease, with a collection of related diseases in various body parts. The conventional therapies cannot show the desired results of treatment due to their imprecise targeting, deprived drug delivery, and side effects. Therefore, it is required to make the drug engineered in such a way that it can target only cancerous cells and can inhibit its growth and proliferation. Nanotechnology is a technology that can target and differentiate between cancerous cells and the normal cells of the body. Silver itself is a good anticancer and antibacterial agent and employing it with phytochemicals having anticancer properties, and nanotechnology can give the best approach for the treatment. The synthesis of silver nanoparticles using plant extracts is an economical, energy-efficient, low-cost approach and it doesn't need any hazardous chemicals. In the present review, we discussed different methods of synthesis of silver nanoparticles using herbal extracts and their role against cancer therapy along with the synergistic role of silver and plant extracts against cancer in the formulation.Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.net.