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The influence of beam optics asymmetric distribution on dose in scanning carbon-ion radiotherapy.

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机构： [1]Shanghai Institute of Applied Physics, Chinese Academy of Sciences, Shanghai, 201800, China. [2]University of Chinese Academy of Sciences, Beijing, 100049, China. [3]College of Physical Science and Technology (College of Nuclear Science and Engineering), Sichuan University, Chengdu, China. [4]Department of Nuclear Medicine, Shanghai Proton and Heavy Ion Center, Fudan University Cancer Hospital, Shanghai, China. [5]Department of Medical Physics, Shanghai Proton and Heavy Ion Center, Shanghai, China. [6]Shanghai Key Laboratory of Radiation Oncology (20dz2261000), Shanghai, China. [7]Shanghai Engineering Research Center of Proton and Heavy Ion Radiation Therapy, Shanghai, China.

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To quantify the influence of beam optics asymmetric distribution on dose.Nine reference cubic targets and corresponding plans with modulation widths (M) of 3, 6, and 9 cm and with center depths (CDs) of 6, 12, and 24 cm were generated by the treatment planning system (TPS). The Monte Carlo code FLUKA was used for simulating the dose distribution from the aforementioned original plans and the dose perturbation by varying ±5%, ±15%, ±20%, ±25%, and ±40% in spot full width half maximum to the X-direction while keeping consistent in the Y-direction. The dosimetric comparisons in dose deviation, γ-index analysis, lateral penumbra, and flatness were evaluated.The largest 3D absolute mean deviation was 15.0% ± 20.9% (mean ± standard deviation) in M3CD6, whereas with the variation from -15% to +20%, the values were below 5% for all cube plans. The lowest 2D γ-index passing rate was 80.6% with criteria of 2%-2 mm by a +40% variation in M3CD6. For the M9CD24 with a -40% variation, the maximum 1D dose deviations were 5.6% and 15.7% in the high-dose region and the edge of the radiation field, respectively. The maximum deviations of penumbra and flatness were 3.4 mm and 11.4%, respectively.The scenario of beam optics asymmetric showed relatively slight influence on the global dose distribution but severely affected dose on the edge of the radiation field. For scanning carbon-ion therapy facilities, beam spot lateral profile settings in TPS base data should be properly handled when beam optics asymmetry variation is over 15%.© 2022 The Authors. Journal of Applied Clinical Medical Physics published by Wiley Periodicals, LLC on behalf of The American Association of Physicists in Medicine.

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出版当年[2022]版：

大类 | 4 区医学

小类 | 4 区核医学

最新[2023]版：

大类 | 4 区医学

小类 | 4 区核医学

第一作者：

第一作者机构： [1]Shanghai Institute of Applied Physics, Chinese Academy of Sciences, Shanghai, 201800, China. [2]University of Chinese Academy of Sciences, Beijing, 100049, China.

通讯作者：

通讯机构： [1]Shanghai Institute of Applied Physics, Chinese Academy of Sciences, Shanghai, 201800, China. [5]Department of Medical Physics, Shanghai Proton and Heavy Ion Center, Shanghai, China. [6]Shanghai Key Laboratory of Radiation Oncology (20dz2261000), Shanghai, China. [7]Shanghai Engineering Research Center of Proton and Heavy Ion Radiation Therapy, Shanghai, China. [*1]Shanghai Engineering Research Center of Proton and Heavy Ion Radiation Therapy, Shanghai,China [*2]Shanghai Institute of Applied Physics, Chinese Academy of Sciences, Shanghai 201800, China.

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