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ROS-triggered Nanoinducer based on Dermatan sulfate enhances immunogenic cell death in melanoma.

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收录情况： ◇ SCIE

作者：
Zhang Qixiong[1,*1] ; Li Shanshan[2] ; Ren Jiandong[1] ; He Xia[1] ; Shi Houkui[3] ; Zhang Fuzhong[3] ; Li Hui[4] ; Tong Rongsheng[1] ;
机构： [1]Department of Pharmacy, Personalized Drug Therapy Key Laboratory of Sichuan Province, Sichuan Academy of Medical Science & Sichuan Provincial People's Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu 610072, China [2]College of Pharmacy, Southwest Minzu University, Chengdu 610000, China [3]Chengdu Institute of Chinese Herbal Medicine, Chengdu 610000, China [4]School of Chemical Engineering, Sichuan University, Chengdu 610000, China
出处：
DOI： 10.1016/j.jconrel.2022.04.026
ISSN：

关键词： Dermatan sulfate Specific-homing Immunogenic cell death Melanoma

摘要：
Due to its complexity, diversity and heterogeneity, melanoma is a kind of malignant tumor. It has been proved that the enhancement of anti-tumor immune response such as immunogenic cell death (ICD) is an important therapeutic strategy. In previous studies, we confirmed that dermatan sulfate (DS) from skin tissue could specifically homing to melanoma B16F10 cells. In this study, we propose a nanoinducer (DOX/ADS NP) based on a functional DS for melanoma. This nanosystem is composed of DS as framework, aromatic thioketal derivative (ATK) as functional grafting unit and doxorubicin (DOX) designed as an ICD inducer. Through the intermolecular interaction between DOX and ATK, DOX/ADS NP with specific-homing, high-loading and ROS-triggering release was obtained via self-assemble. Compared with free DOX and non-functionalized nanomedicine, DOX/ADS NP could release DOX into B16F10 cells better, and strongly induce the translocation of calreticulin (CRT) to the cell membrane. CRT is a marker of ICD, also as a "eat me" signal to stimulate the maturation and antigen presentation of dendritic cells. Therefore, a series of subsequent immune responses were activated: maturation of dendritic cells, T cells proliferation, increased tumor-infiltrating CTLs and the ratio of CTLs to Tregs, and up-regulated cytotoxic cytokine expression. In conclusion, DOX/ADS NP promoted ICD-associated immune response through more specific targeting effect and sensitive responsive DOX release, achieving better inhibitory effect on melanoma than free DOX and other nanoformulation. This biomimetic ICD nanoinducer based on DS is expected to provide new strategies and references for the treatment of melanoma.Copyright © 2021. Published by Elsevier B.V.

基金：
This work was supported by grants from the Sichuan Science and Technology Program [2019YFS0514, 2021YJ0128], Southwest Minzu University Research Startup Funds [RQD2022033], the Fundamental Research Funds for the Central Universities [ZYN2022057], the National Key Research and Development Program of China [2020YFC2005500], the National Natural Science Foundation of China [81570582, 82170660] and the Sichuan Provincial People's Hospital [30420200034, 30420210026-2].

基金编号： 2019YFS0514 2021YJ0128] Southwest Minzu University Research Startup Funds [RQD2022033] the Fundamental Research Funds for the Central Universities [ZYN2022057] the National Key Research and Development Program of China [2020YFC2005500] the National Natural Science Foundation of China [81570582 82170660] and the Sichuan Provincial People's Hospital [30420200034 30420210026-2

语种：
外文
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出版当年[2022]版：
大类 | 1 区 医学
小类 | 1 区 药学 1 区 化学：综合
最新[2023]版：
大类 | 1 区 医学
小类 | 1 区 化学：综合 1 区 药学
JCR分区：
出版当年[2022]版：
Q1 CHEMISTRY, MULTIDISCIPLINARY Q1 PHARMACOLOGY & PHARMACY
最新[2023]版：
Q1 CHEMISTRY, MULTIDISCIPLINARY Q1 PHARMACOLOGY & PHARMACY

影响因子： 最新[2023版] 最新五年平均 出版当年[2022版] 出版当年五年平均 出版前一年[2021版] 出版后一年[2023版]

第一作者：
第一作者机构： [1]Department of Pharmacy, Personalized Drug Therapy Key Laboratory of Sichuan Province, Sichuan Academy of Medical Science & Sichuan Provincial People's Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu 610072, China [*1]Department of Pharmacy, Personalized Drug Therapy Key Laboratory of Sichuan Province, Sichuan Academy of Medical Science & Sichuan Provincial People's Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu 610072, China.
共同第一作者：
通讯作者：
通讯机构： [1]Department of Pharmacy, Personalized Drug Therapy Key Laboratory of Sichuan Province, Sichuan Academy of Medical Science & Sichuan Provincial People's Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu 610072, China [*1]Department of Pharmacy, Personalized Drug Therapy Key Laboratory of Sichuan Province, Sichuan Academy of Medical Science & Sichuan Provincial People's Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu 610072, China.
推荐引用方式(GB/T 7714)：
Zhang Qixiong,Li Shanshan,Ren Jiandong,et al.ROS-triggered Nanoinducer based on Dermatan sulfate enhances immunogenic cell death in melanoma.[J].JOURNAL OF CONTROLLED RELEASE.2022,348:22-33.doi:10.1016/j.jconrel.2022.04.026.
APA：
Zhang Qixiong,Li Shanshan,Ren Jiandong,He Xia,Shi Houkui...&Tong Rongsheng.(2022).ROS-triggered Nanoinducer based on Dermatan sulfate enhances immunogenic cell death in melanoma..JOURNAL OF CONTROLLED RELEASE,348,
MLA：
Zhang Qixiong,et al."ROS-triggered Nanoinducer based on Dermatan sulfate enhances immunogenic cell death in melanoma.".JOURNAL OF CONTROLLED RELEASE 348.(2022):22-33

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