详情页 - 四川省肿瘤医院知识库

当前位置：首页 > 详情页

Effect of Lactobacillus fermentum HFY06 Combined with Arabinoxylan on Reducing Lipid Accumulation in Mice Fed with High-Fat Diet.

文献详情

资源类型：

Pubmed体系：

作者：

机构： [1]Chongqing Collaborative Innovation Center for Functional Food, Chongqing Engineering Research Center of Functional Food, Chongqing Engineering Laboratory for Research and Development of Functional Food, Chongqing University of Education, Chongqing 400067, China [2]College of Biological and Chemical Engineering, Chongqing University of Education, Chongqing 400067, China [3]Department of Pain Medicine, The Ninth People’s Hospital of Chongqing, Chongqing, 400799 Sichuan, China [4]College of Food Science, Southwest University, Chongqing 400700, China [5]National Teaching Demonstration Center of Food Science and Engineering, Southwest University, Chongqing 400700, China [6]Chongqing Key Laboratory of Translational Research for Cancer Metastasis and Individualized Treatment, Chongqing University Cancer Hospital & Chongqing Cancer Institute & Chongqing Cancer Hospital, Chongqing 400030, China [7]Department of Public Health, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China

出处：

DOI：

ISSN：

摘要：

In this experiment, a high-fat diet was used to induce hyperlipidemia in mice to determine the synergistic effect of AX and L. fermentum HFY06 on the prevention of hyperlipidemia and its potential regulatory mechanism. The results of this study showed that after the AX and L. fermentum HFY06 synergistic intervention, the body weight, epididymal fat index, blood lipid level, and liver function indexes of mice were improved. In addition, the synbiotics comprising AX and L. fermentum HFY06 increased the CAT activity in the serum of mice on a high-fat diet, reduced NO and MDA levels, and improved the body's oxidative stress. From the perspective of molecular biology, on the one hand, AX and L. fermentum HFY06 synergistic intervention activated the AMPK pathway to regulate body lipid metabolism; up-regulated the mRNA expressions of CPT-1, PPAR-α, CYP7A1, and HSL; and down-regulated the mRNA expressions of ACC, C/EBPα, and LPL. On the other hand, the synergistic effect of AX and HFY06 enhanced the mRNA expressions of ZO-1, occludin, and claudin-1 in the small intestine of mice, increased the strength of the intestinal barrier, and optimized the composition of the intestinal microbiota. From the above results, it can be concluded that AX and L. fermentum HFY06 have a synergistic effect in improving hyperlipidemia. However, this study was only performed using animal models, and the lipid synthesis and metabolism mechanism are complicated; hence, further clinical studies are needed.Copyright © 2022 Fang Li et al.

基金：

语种：

PubmedID：

中科院(CAS)分区：

出版当年[2022]版：

大类 | 2 区生物学

小类 | 2 区细胞生物学

最新[2023]版：

无

第一作者：

第一作者机构： [1]Chongqing Collaborative Innovation Center for Functional Food, Chongqing Engineering Research Center of Functional Food, Chongqing Engineering Laboratory for Research and Development of Functional Food, Chongqing University of Education, Chongqing 400067, China [2]College of Biological and Chemical Engineering, Chongqing University of Education, Chongqing 400067, China

共同第一作者：

通讯作者：

通讯机构： [1]Chongqing Collaborative Innovation Center for Functional Food, Chongqing Engineering Research Center of Functional Food, Chongqing Engineering Laboratory for Research and Development of Functional Food, Chongqing University of Education, Chongqing 400067, China [2]College of Biological and Chemical Engineering, Chongqing University of Education, Chongqing 400067, China

推荐引用方式(GB/T 7714)：

APA：

MLA：