详情页 - 四川省肿瘤医院知识库

当前位置：首页 > 详情页

Metabolomics reveals the role of PPARα in Tripterygium Wilfordii-induced liver injury.

文献详情

资源类型：

Pubmed体系：

作者：

机构： [1]State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, 650201, China [2]University of Chinese Academy of Sciences, Beijing, 100049, China [3]Laboratory of Metabolomics and Drug-induced Liver Injury, Frontiers Science Center for Disease-related Molecular Network, West China Hospital, Sichuan University, Chengdu, 610041, China [4]Institute of Rare Diseases, West China Hospital of Sichuan University, Chengdu, 610041, China [5]Department of Gastroenterology and Hepatology, Sichuan University-University of Oxford Huaxi Joint Centre for Gastrointestinal Cancer, Frontiers Science Center for Disease-Related Molecular Network, West China Hospital, Sichuan University, Chengdu, 610041, China

出处：

DOI：

ISSN：

关键词： Tripterygium wilfordii Liver injury PPARα IL6-STAT3 Metabolomics

摘要：

Tripterygium glycosides tablets (TGT) and Tripterygium wilfordii tablets (TWT) have been used to treat autoimmune diseases clinically, however, the side effects of TWT are higher than TGT, especially for hepatotoxicity.This study aims to determine the mechanism of TWT-induced liver injury.We performed metabolomic analysis of samples from mice with liver injury induced by TGT and TWT. Ppara-null mice were used to determine the role of PPARα in TWT-induced liver injury.The results indicated that TWT induced the accumulation of medium- and long-chain carnitines metabolism, which was associated with the disruption of PPARα-IL6-STAT3 axis. PPARα agonists fenofibrate could reverse the liver injury from TWT and TP/Cel, and its protective role could be attenuated in Ppara-null mice. The toxicity difference of TWT and TGT was due to the different ratio of triptolide (TP) and celastrol (Cel) in the tablet in which TP/Cel was lower in TWT than TGT. The hepatotoxicity induced by TP and Cel also inhibited PPARα and upregulated IL6-STAT3 axis, which could be alleviated following by PPARα activation.These results indicated that PPARα plays an important role in the hepatotoxicity of Tripterygium wilfordii, and PPARα activation may offer a promising approach to prevent hepatotoxicity induced by the preparations of Tripterygium wilfordii.Copyright © 2022 Elsevier B.V. All rights reserved.

基金：

语种：

PubmedID：

中科院(CAS)分区：

出版当年[2022]版：

大类 | 2 区

医学

小类 | 1 区药学 1 区全科医学与补充医学 1 区植物科学 2 区药物化学

最新[2023]版：

大类 | 2 区

医学

小类 | 1 区药物化学 1 区全科医学与补充医学 1 区药学 1 区植物科学

第一作者：

第一作者机构： [1]State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, 650201, China [2]University of Chinese Academy of Sciences, Beijing, 100049, China [3]Laboratory of Metabolomics and Drug-induced Liver Injury, Frontiers Science Center for Disease-related Molecular Network, West China Hospital, Sichuan University, Chengdu, 610041, China

共同第一作者：

通讯作者：

通讯机构： [1]State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, 650201, China [3]Laboratory of Metabolomics and Drug-induced Liver Injury, Frontiers Science Center for Disease-related Molecular Network, West China Hospital, Sichuan University, Chengdu, 610041, China [5]Department of Gastroenterology and Hepatology, Sichuan University-University of Oxford Huaxi Joint Centre for Gastrointestinal Cancer, Frontiers Science Center for Disease-Related Molecular Network, West China Hospital, Sichuan University, Chengdu, 610041, China [*1]Laboratory of metabolomics and drug-induced liver injury, Frontiers Science Center for Disease-related Molecular Network, West China Hospital, Sichuan University, Chengdu, 610041, China

推荐引用方式(GB/T 7714)：

APA：

MLA：

Metabolomics reveals the role of PPARα in Tripterygium Wilfordii-induced liver injury.

文献详情

相关文献