机构：[1]Department of Urology, Institute of Urology, West China Hospital, Sichuan University, Chengdu, China.四川大学华西医院[2]Department of Pediatrics, West China Second University Hospital, Sichuan University, Chengdu, China.[3]Key Laboratory of Birth Defects and Related Diseases of Women and Children (Sichuan University), Ministry of Education, Chengdu, China.
The aim of our study was to elaborate the association between metabolic syndrome (MS) and the tumor stage and grade of bladder cancer (BC).A systematic review and pooled analysis on PubMed, the Cochrane Library, Embase, Web of Science, CNKI, WANFANG and VIP from databases inception to July 24, 2020 was conducted by two independent authors. Relative risk (RR) was used as pooled effect estimates. The data analysis was accomplished by STATA 14.2.Three English and four Chinese articles were included in the final analysis. A pooled analysis of six studies showed that patients in MS group were at a 1.94-fold risk of high-stage BC when compared to their counterparts (RR: 1.94; 95% CI: 1.59-2.37), and the difference was statistically significant. For the components of MS, except for hypertension, patients with obesity (RR: 1.61; 95% CI: 1.33-1.95), hyperglycemia (RR: 2.20; 95% CI: 1.49-3.26) and low high-density lipoprotein cholesterol (HDL) (RR: 1.98; 95% CI: 1.51-2.58) had significantly higher risks of high-stage BC than the control groups. A pooled analysis of six studies indicated that MS can contribute substantially to the vulnerability of high-grade BC with significant difference (RR: 1.50; 95% CI: 1.37-1.65). Furthermore, patients with obesity (RR: 1.41; 95% CI: 1.18-1.69), hyperglycemia (RR: 1.42; 95% CI: 1.30-1.56), hypertension (RR: 1.13; 95% CI: 1.03-1.24), low HDL (RR: 1.29; 95% CI: 1.14-1.46) and high triglyceride (TG) (RR: 1.28; 95% CI: 1.11-1.46) were at a higher risk of high-grade BC than their counterparts.This meta-analysis revealed that MS and its components might be associated with high BC stage and grade.2021 Translational Cancer Research. All rights reserved.
基金：
Funding: This work was supported by Department of Science and Technology of Sichuan Province (2020YFH0099) and the National Natural Science Foundation of China (No. 81370272, 30901621/C1705).
语种：
外文
PubmedID：
中科院(CAS)分区：
出版当年[2021]版：
大类|4 区医学
小类|4 区肿瘤学
最新[2023]版：
大类|4 区医学
小类|4 区肿瘤学
第一作者：
第一作者机构：[1]Department of Urology, Institute of Urology, West China Hospital, Sichuan University, Chengdu, China.
共同第一作者：
通讯作者：
通讯机构：[2]Department of Pediatrics, West China Second University Hospital, Sichuan University, Chengdu, China.[3]Key Laboratory of Birth Defects and Related Diseases of Women and Children (Sichuan University), Ministry of Education, Chengdu, China.[*1]Department of Pediatrics, West China Second University Hospital, Sichuan University, No. 20, Section 3, Renmin Nan Lu, Chengdu 610041, China.
推荐引用方式(GB/T 7714)：
Feng Dechao,Song Pan,Yang Yubo,et al.Is metabolic syndrome associated with high tumor grade and stage of bladder cancer: a systematic review and meta-analysis.[J].Translational cancer research.2021,10(5):2188-2198.doi:10.21037/tcr-20-3350.
APA：
Feng Dechao,Song Pan,Yang Yubo,Wei Wuran&Li Li.(2021).Is metabolic syndrome associated with high tumor grade and stage of bladder cancer: a systematic review and meta-analysis..Translational cancer research,10,(5)
MLA：
Feng Dechao,et al."Is metabolic syndrome associated with high tumor grade and stage of bladder cancer: a systematic review and meta-analysis.".Translational cancer research 10..5(2021):2188-2198
