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Prognostic Value of the Geriatric Nutritional Risk Index in Non-Small Cell Lung Cancer Patients: A Systematic Review and Meta-Analysis.

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机构： [1]Department of Respiratory and Critical Care Medicine, West China Hospital, Sichuan University, Chengdu, China. [2]Institute of Respiratory Health, Frontiers Science Center for Disease-Related Molecular Network, West China Hospital, Sichuan University, Chengdu, China.

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Novel evidence showed that the Geriatric Nutritional Risk Index (GNRI) may lead to poor prognosis of human cancers. Therefore, we conducted a meta-analysis to explore the impact of GNRI in lung cancer and its prognostic value.We searched the databases of PubMed, Web of Science, Embase, Scopus, and Cochrane Library up to July 2021 for relevant research and merged the hazard ratios (HRs) and 95% confidence intervals (CIs) to evaluate the association between GNRI and overall survival (OS), cancer-specific survival (CSS), and recurrence-free survival (RFS) in patients with lung cancer.Eight studies involving 2,399 patients were included in our primary meta-analysis. The results indicated that lower level of GNRI was associated with poorer OS, RFS, and CSS of lung cancer patients (OS: HR = 1.99, 95% CI: 1.68-2.35, p < 0.0001; RFS: HR = 2.34, 95% CI: 1.11-4.95, p = 0.0258; CSS: HR = 2.45, 95% CI: 1.43-4.18, p = 0.0011). The association was robust after subgroup analysis and sensitivity analysis.GNRI may be a prognostic factor of lung cancer, which can lead to poorer survival. However, more prospective studies are necessary to confirm the results.International Prospective Register of Systematic Reviews (PROSPERO), identifier CRD42021269574.Copyright © 2022 Wang, Li, Yang, Jin, Liu and Li.

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大类 | 3 区医学

小类 | 3 区肿瘤学

最新[2023]版：

大类 | 3 区医学

小类 | 3 区肿瘤学

第一作者：

第一作者机构： [1]Department of Respiratory and Critical Care Medicine, West China Hospital, Sichuan University, Chengdu, China. [2]Institute of Respiratory Health, Frontiers Science Center for Disease-Related Molecular Network, West China Hospital, Sichuan University, Chengdu, China.

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通讯机构： [1]Department of Respiratory and Critical Care Medicine, West China Hospital, Sichuan University, Chengdu, China. [2]Institute of Respiratory Health, Frontiers Science Center for Disease-Related Molecular Network, West China Hospital, Sichuan University, Chengdu, China.

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