个人中心| | 帮助
高级检索
当前位置： 首页 > 详情页

Value of intravoxel incoherent motion for assessment of lymph node status and tumor response after chemoradiation therapy in locally advanced rectal cancer.

| 导出 | |

文献详情

资源类型：
WOS体系：
Pubmed体系：

收录情况： ◇ SCIE

作者：
Li Hang[1,2] ; Yuan Yi[2] ; Chen Xiao Li[3] ; Chen Guang Wen[2] ; Liu Hao[4] ; Liu Yi Sha[5] ; Pang Ming Hui[6] ; Liu Si Yun[7] ; Pu Hong[2] ; Li Zhen Lin[1,*1] ;
机构： [1]Department of Radiology, West China Hospital, Sichuan University, Chengdu 610041, China [2]Department of Radiology, Sichuan Academy of Medical Sciences and Sichuan Provincial People’s Hospital, 32# Second Section of First Ring Road, Qingyang District, Chengdu 610070, Sichuan, China [3]Department of Radiology, Affiliated Cancer Hospital of Medical School, University of Electronic Science and Technology of China, Sichuan Cancer Hospital, Chengdu 610000, China [4]Department of Oncology, Sichuan Academy of Medical Sciences and Sichuan Provincial People’s Hospital, 32# Second Section of First Ring Road, Qingyang District, Chengdu 610070, Sichuan, China [5]Department of Pathology, Sichuan Academy of Medical Sciences and Sichuan Provincial People’s Hospital, 32# Second Section of First Ring Road, Qingyang District, Chengdu 610070, Sichuan, China [6]Department of Gastrointestinal Surgery, Sichuan Academy of Medical Sciences and Sichuan Provincial People’s Hospital, 32# Second Section of First Ring Road, Qingyang District, Chengdu 610070, Sichuan, China [7]GE Healthcare (China), 1# Tongji South Road, Daxing District, Beijing 100176, China
出处：
DOI： 10.1016/j.ejrad.2021.110106
ISSN：

摘要：
To assess the role of region of interest (ROI) selection of intravoxel incoherent motion (IVIM) for predicting lymph node metastases (LNM) and tumor response after chemoradiation therapy (CRT) in locally advanced rectal cancer.Seventy-nine patients with biopsy-proven rectal adenocarcinoma who underwent pre- and post-CRT MRI and surgery were prospectively enrolled. The exclusion criteria included nonresectable and/or metastatic disease and loss of follow-up. Pathological stage was determined using ypTNM stage and tumor regression grade. Slow diffusion coefficient (D), fast diffusion coefficient (D*), perfusion-related diffusion fraction (f), apparent diffusion coefficient (ADC) and their percentage changes (Δ%) were evaluated by two readers using whole-volume, single-slice and small samples ROI methods. Risk factors including carcinoembryonic antigen, post-CRT T-staging, extramural venous invasion and IVIM parameters were evaluated through multivariate analyses. Areas under the receiver operating characteristic curves (AUCs) were calculated to evaluate diagnostic performance. Duration of follow-up was two-year. Recurrence-free survival of patients with LNM and tumor response was estimated using Kaplan-Meier analysis.Interobserver agreement were good for pre- and post-CRT three ROI methods (intraclass correlation coefficient [ICC], 0.581-0.953). Whole-volume ROI-derived Δ%D was an independent risk factor for LNM, non-pathological complete response (non-pCR) and poor response (odds ratio, 0.940, 0.952, 0.805, respectively; all p < 0.001). Whole-volume ROI-derived Δ%D showed best AUC of 0.810, 0.851 and 0.903 for LNM, non-pCR and poor response (cutoff value, 31.8%, 54.5%, 52.8%, respectively). Patients with post-CRT LNM showed reduction in 2-year recurrence-free survival (hazard ratio, 3.253).Whole-volume ROI-derived Δ%D provided high diagnostic performance for evaluating post-CRT LNM and tumor response. Patients with post-CRT LNM showed earlier recurrence.Copyright © 2021 Elsevier B.V. All rights reserved.

基金：
This work was supported by Sichuan Science and Technology Program (grant number, No. 2020YFH0166) and the Key Research Project of Sichuan Province (grant number, No. 22ZDYF1998).
语种：
外文
被引次数：
WOS：
PubmedID：
中科院(CAS)分区：
出版当年[2022]版：
大类 | 3 区 医学
小类 | 3 区 核医学
最新[2023]版：
大类 | 3 区 医学
小类 | 3 区 核医学
JCR分区：
出版当年[2022]版：
Q2 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING
最新[2023]版：
Q1 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING

影响因子： 最新[2023版] 最新五年平均 出版当年[2022版] 出版当年五年平均 出版前一年[2021版] 出版后一年[2023版]

第一作者：
第一作者机构： [1]Department of Radiology, West China Hospital, Sichuan University, Chengdu 610041, China [2]Department of Radiology, Sichuan Academy of Medical Sciences and Sichuan Provincial People’s Hospital, 32# Second Section of First Ring Road, Qingyang District, Chengdu 610070, Sichuan, China
共同第一作者：
通讯作者：
通讯机构： [1]Department of Radiology, West China Hospital, Sichuan University, Chengdu 610041, China [*1]Department of Radiology, West China Hospital, Sichuan University, No. 37, GUOXUE Alley, Chengdu 610041, China.
推荐引用方式(GB/T 7714)：
Li Hang,Yuan Yi,Chen Xiao Li,et al.Value of intravoxel incoherent motion for assessment of lymph node status and tumor response after chemoradiation therapy in locally advanced rectal cancer.[J].EUROPEAN JOURNAL OF RADIOLOGY.2022,146:doi:10.1016/j.ejrad.2021.110106.
APA：
Li Hang,Yuan Yi,Chen Xiao Li,Chen Guang Wen,Liu Hao...&Li Zhen Lin.(2022).Value of intravoxel incoherent motion for assessment of lymph node status and tumor response after chemoradiation therapy in locally advanced rectal cancer..EUROPEAN JOURNAL OF RADIOLOGY,146,
MLA：
Li Hang,et al."Value of intravoxel incoherent motion for assessment of lymph node status and tumor response after chemoradiation therapy in locally advanced rectal cancer.".EUROPEAN JOURNAL OF RADIOLOGY 146.(2022)

资源点击量：43389 今日访问量：0 总访问量：3120 更新日期：2024-09-01 建议使用谷歌、火狐浏览器 常见问题

版权所有©2020 四川省肿瘤医院 技术支持：重庆聚合科技有限公司 地址：成都市人民南路四段55号