机构：[1]Department of Obstetrics and Gynecology, People’s Hospital of Leshan, Leshan, China[2]Department of Gynaecological Oncology, Sichuan Cancer Hospital & Institute, Sichuan Cancer Center, School of Medicine, University of Electronic Science and Technology of China, Chengdu, China四川省人民医院四川省肿瘤医院[3]Department of Academic Journal, Sichuan Provincial People’s Hospital, University of Electronic Science and Technology of China, Chengdu, China四川省人民医院[4]Chinese Academy of Sciences Sichuan Translational Medicine Research Hospital, Chengdu, China四川省人民医院[5]Department of Gynaecology and Obstetrics, Sichuan Provincial People’s Hospital, University of Electronic Science and Technology of China, Chengdu, China四川省人民医院
Background: It is important to investigate the risk factors of the failure of conservative treatment for cesarean scar pregnancy in order to improve the success rate of treatment and preserve the fertility of patients. This article aims to investigate these factors by meta-analysis, so as to serve as a clinical reference. Methods: PubMed, MEDLINE, Embase, and the Cochrane Library databases were searched. Literatures related to the treatment of cesarean scar pregnancy (CSP) were selected. Literatures were screened according to the inclusion and exclusion criteria, and the quality was evaluated. RevMan 5.3.5 software was used to conduct the meta-analysis on the factors of treatment failure. Results: A total of 7 articles were included in this study, involving 251 patients. Among them, there were 79 (31.5%) cases of conservative treatment failure. The results of the meta-analysis showed that more than 2 cesarean sections [OR =1.79, 95% CI: (0.94, 3.42), P=0.08], mass type CSP [OR =4.06, 95% CI: (2.11, 7.81), P<0.0001], serum beta-hCG value <20,000 U/L [OR =1.81, 95% CI: (0.92, 3.54), P=0.09], and pregnancy time over 3 years from last cesarean section [OR =4.12, 95% CI: (1.29, 13.08), P=0.02] were the risk factors for the failure of conservative treatment of CSP. Discussion: A total of 7 studies were included in this meta-analysis. The results showed that more than 2 cesarean sections, mass type CSP, serum beta-hCG value <20,000 U/L, and pregnancy time over 3 years from last cesarean section were risk factors for the failure of conservative treatment of CSP. Patients with the above risk factors should be screened and informed of the possibility of conservative treatment failure in a timely manner, and different methods should be considered for treatment.
第一作者机构：[1]Department of Obstetrics and Gynecology, People’s Hospital of Leshan, Leshan, China
通讯作者：
通讯机构：[3]Department of Academic Journal, Sichuan Provincial People’s Hospital, University of Electronic Science and Technology of China, Chengdu, China[4]Chinese Academy of Sciences Sichuan Translational Medicine Research Hospital, Chengdu, China[5]Department of Gynaecology and Obstetrics, Sichuan Provincial People’s Hospital, University of Electronic Science and Technology of China, Chengdu, China[*1]Sichuan Provincial People’s Hospital, University of Electronic Science and Technology of China, Chengdu 610072, China[*2]Chinese Academy of Sciences Sichuan Translational Medicine Research Hospital, No. 32, West Section 2, First Ring Road, Qingyang District, Chengdu 610072, China.
推荐引用方式(GB/T 7714)：
Wan Xiaoli,Liao Yun,Hu Ting,et al.A systematic review and meta-analysis of risk factors in the conservative treatment of cesarean scar pregnancy[J].ANNALS OF PALLIATIVE MEDICINE.2021,10(10):10434-10443.doi:10.21037/apm-21-2169.
APA：
Wan, Xiaoli,Liao, Yun,Hu, Ting,Xu, Hongmei,Xia, Xiuying...&Wang, Yan.(2021).A systematic review and meta-analysis of risk factors in the conservative treatment of cesarean scar pregnancy.ANNALS OF PALLIATIVE MEDICINE,10,(10)
MLA：
Wan, Xiaoli,et al."A systematic review and meta-analysis of risk factors in the conservative treatment of cesarean scar pregnancy".ANNALS OF PALLIATIVE MEDICINE 10..10(2021):10434-10443
