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Study on the Impact of Antioxidant on the FLASH Effect With 6 MeV X-Ray.

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收录情况： ◇ SCIE ◇ EI

作者：
Zhu H[1] * ; Xie D H[2] ; Yang Y[3] ; Wu D[4] ; Huang S M[5] ; Gao X[6] ; Peng Y[7] ; Wang B[8] ; Li C[9] ; Wang J[4] ; Xiao D[4] ; Li C[10] ; Qian C N[11] ; Deng X[7] ;
机构： [1]Department of Radiation Oncology, Sun Yat-Sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou, China, [2]Department ofNasopharyngeal Carcinoma, Sun Yat-Sen University Cancer Center, StateKey Laboratory of Oncology in Southern China, Collaborative InnovationCenter for Cancer Medicine, Guangzhou 510060, China, [3]Institute ofNuclear Physics and Chemistry, China Academy of Engineering Physics,Mianyang, China, [4]Institute of Applied Electronics, China Academy ofEngineering Physics, Mianyang, China, [5]Sun Yat-Sen University CancerCenter, Guangzhou, China, [6]Guangdong Provincial People’s Hospital,Guangzhou, China, [7]Sun Yat-Sen University Cancer Center, State KeyLaboratory of Oncology in South China, Collaborative Innovation Centerfor Cancer Medicine, Guangzhou, China, [8]State Key Laboratory of Oncology in South China [C]ollaborative Innovation Center for Cancer Medicine [D]epartment of Radiation Oncology, Sun Yat-Sen University CancerCenter., Guangzhou, China, [9]Sun Yat-Sen University Cancer Center, StateKey Laboratory of Oncology in Southern China, Collaborative InnovationCenter for Cancer Medicine, Guangzhou, China, [10]College of Life Science,Sichuan University, Chengdu, China, [11]Department of Nasopharyngeal Carcinoma, Sun Yat-Sen University Cancer Center, State Key Laboratoryof Oncology in Southern China, Collaborative Innovation Center for Cancer Medicine, Guangzhou, China
出处：
DOI： 10.1016/j.ijrobp.2021.07.822
ISSN：

摘要：
Recent studies reported that the ultra-high dose rate (FLASH) irradiation induced less healthy tissue damages compared with conventional dose rate (CONV) irradiation, this phenomenon was referred to as the FLASH effect and the underlying mechanism remains elusive. This work aims to investigate the impact of antioxidants on the FLASH effect.BALB/c nude mice were treated with the antioxidant N-Acetylcysteine (NAC) and received whole abdominal 6 MeV X-ray FLASH (> 150 Gy/s) or CONV (0.2 Gy/s) irradiation. The prescribed doses were 16 Gy (lethal dose) and 10 Gy (non-lethal dose). EBT3 films were used to confirm the dose. Mice were sacrificed 24 h post-irradiation (pi) to study acute tissue responses or followed up to 6 weeks to look at late-stage responses and the survival probability. Whole blood count, cytokine expression, histologic analysis, and TUNEL assay of intestine were used performed.Mice that received FLASH irradiation had a higher survival probability 6 weeks pi, and less acute and late-stage intestine damages compared to CONV irradiation. For mice that received FLASH irradiation, there are no statistically significant differences in whole blood count, survival probability and intestine damages between NAC treated group and the non-NAC treated group. However, for mice who received CONV irradiation, mice treated with NAC had significantly lower survival probability, more white blood cells, lymphocytes, and neutrophils compared to those not treated with NAC.6 MeV X-ray FLASH irradiation can spare healthy tissues compared to CONV irradiation. Administration of antioxidant lead to more radiation induced damages under CONV irradiation but no statistic significant impact on the tissue response to FLASH irradiation. More (ongoing) experiments should be performed to study the role of antioxidants in the FLASH effect.Copyright © 2021. Published by Elsevier Inc.

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出版当年[2021]版：
大类 | 2 区 医学
小类 | 2 区 肿瘤学 2 区 核医学
最新[2025]版：
大类 | 1 区 医学
小类 | 2 区 肿瘤学 2 区 核医学
JCR分区：
出版当年[2021]版：
Q1 ONCOLOGY Q1 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING
最新[2024]版：
Q1 ONCOLOGY Q1 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING

影响因子： 最新[2024版] 最新五年平均 出版当年[2021版] 出版当年五年平均 出版前一年[2020版] 出版后一年[2022版]

第一作者：
第一作者机构： [1]Department of Radiation Oncology, Sun Yat-Sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou, China,
推荐引用方式(GB/T 7714)：
Zhu H,Xie D H,Yang Y,et al.Study on the Impact of Antioxidant on the FLASH Effect With 6 MeV X-Ray.[J].INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS.2021,111(3):E244-E244.doi:10.1016/j.ijrobp.2021.07.822.
APA：
Zhu H,Xie D H,Yang Y,Wu D,Huang S M...&Deng X.(2021).Study on the Impact of Antioxidant on the FLASH Effect With 6 MeV X-Ray..INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS,111,(3)
MLA：
Zhu H,et al."Study on the Impact of Antioxidant on the FLASH Effect With 6 MeV X-Ray.".INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS 111..3(2021):E244-E244

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