机构：[1]Department of Anesthesiology, Second Affiliated Hospital, Army Medical University, Chongqing 400037, China[2]Department ofAnesthesiology, Yongchuan Hospital, Chongqing Medical University, Chongqing 402160, China[3]Department of Radiology, ChongqingUniversity Cancer Hospital & Chongqing Cancer Institute & Chongqing Cancer Hospital, Chongqing 400030, China[4]Department ofAnesthesiology, Affiliated Hospital of Southwest Medical University, Luzhou 646000, Sichuan, China
Ubiquinol-cytochrome c reductase core protein 1 (UQCRC1) is an indispensable component of mitochondrial complex III. It plays a key role in cardioprotection and maintaining mitochondrion function. However, the exact role of UQCRC1 in maintaining cardiac function has not been reported by in vivo models. Also, the exact biological functions of UQCRC1 are far from fully understood. UQCRC1+/- mice had decreased both mRNA and protein expression of UQCRC1 in the left ventricular myocardia, and these mice had reduced tolerance to acute exhaustive exercise including decreased time and distance with higher apoptosis rate, higher expression level of cleaved CASPASE 3, and higher ratio of cleaved PARP1 to full-length PARP1. Moreover, UQCRC1 knockdown led to increased LV interventricular septal thicknesses both at systole and diastole, as well as decreased LV volume both at end-systole and end-diastole. Finally, UQCRC1 gene disruption resulted in mitochondrial vacuolation, fibril disarrangement, and more severe morphological and structural changes in mitochondria after acute exhaustive exercise. In conclusion, UQCRC1 contributes to cardiac tolerance to acute exhaustive exercise in mice, and it may be an essential component of complex III, playing a crucial role in maintaining cardiac functions.
基金：
The author(s) disclosed receipt of the following financial support for the research, authorship, and/or publication of this
article: This work was supported by the National Natural
Science Foundation of China [Grant no. 81070094] and
Natural Science Foundation of Chongqing [Grant no.
CSTC2019jcyj-zdxmX0001].
语种：
外文
PubmedID：
中科院(CAS)分区：
出版当年[2021]版：
大类|4 区医学
小类|4 区医学：研究与实验
最新[2023]版：
大类|4 区医学
小类|4 区医学：研究与实验
第一作者：
第一作者机构：[1]Department of Anesthesiology, Second Affiliated Hospital, Army Medical University, Chongqing 400037, China[2]Department ofAnesthesiology, Yongchuan Hospital, Chongqing Medical University, Chongqing 402160, China
共同第一作者：
推荐引用方式(GB/T 7714)：
Yi Tingting,Chen Huifang,Zhan Jian,et al.Ubiquinol-cytochrome c reductase core protein 1 contributes to cardiac tolerance to acute exhaustive exercise.[J].Experimental biology and medicine (Maywood, N.J.).2021,15353702211046546.doi:10.1177/15353702211046546.
APA：
Yi Tingting,Chen Huifang,Zhan Jian,Li Yu,Long Zonghong...&Li Hong.(2021).Ubiquinol-cytochrome c reductase core protein 1 contributes to cardiac tolerance to acute exhaustive exercise..Experimental biology and medicine (Maywood, N.J.),,
MLA：
Yi Tingting,et al."Ubiquinol-cytochrome c reductase core protein 1 contributes to cardiac tolerance to acute exhaustive exercise.".Experimental biology and medicine (Maywood, N.J.) .(2021):15353702211046546
