机构：[1]College of Medical Technology, Sichuan College of Traditional Chinese Medicine, Mianyang, Sichuan 621000[2]Institute of Drug Clinical Trial/GCP Center, Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan 646000, P.R. China[3]Department of Oncology, Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan 646000, P.R. China
Patients with a variety of malignancies can develop malignant pleural effusion (MPE). MPE can cause significant symptoms and result in a marked decrease in quality of life and a poor prognosis. MPE is primarily considered as an immune and vascular manifestation of pleural metastases. In the present review, the existing evidence supporting the applicability of anti‑angiogenic therapy and immunotherapy for the treatment of MPE was summarized. Patients with MPE have benefited from anti‑angiogenic agents, including bevacizumab and endostar; however, no relevant prospective phase III trial has, thus far, specifically analyzed the benefit of anti‑angiogenic therapy in MPE. Immunotherapy for MPE may be sufficient to turn a dire clinical situation into a therapeutic advantage. Similar to anti‑angiogenic therapy, more clinical data on the efficiency and safety of immunotherapy for controlling MPE are urgently required. The combined use of anti‑angiogenic therapy and immunotherapy may be a promising strategy for MPE, which requires to be further understood.
语种：
外文
PubmedID：
中科院(CAS)分区：
出版当年[2021]版：
大类|2 区医学
小类|3 区肿瘤学
最新[2023]版：
大类|3 区医学
小类|3 区肿瘤学
第一作者：
第一作者机构：[1]College of Medical Technology, Sichuan College of Traditional Chinese Medicine, Mianyang, Sichuan 621000
共同第一作者：
通讯作者：
通讯机构：[2]Institute of Drug Clinical Trial/GCP Center, Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan 646000, P.R. China[*1]Institute of Drug Clinical Trial/GCP Center, Affiliated Hospital of Southwest Medical University, 25 Taiping Street, Luzhou, Sichuan 646000, P.R. China
推荐引用方式(GB/T 7714)：
He Dan,Ding Ruilin,Wen Qinglian,et al.Novel therapies for malignant pleural effusion: Anti‑angiogenic therapy and immunotherapy (Review).[J].International journal of oncology.2021,58(3):359-370.doi:10.3892/ijo.2021.5174.
APA：
He Dan,Ding Ruilin,Wen Qinglian&Chen Longxia.(2021).Novel therapies for malignant pleural effusion: Anti‑angiogenic therapy and immunotherapy (Review)..International journal of oncology,58,(3)
MLA：
He Dan,et al."Novel therapies for malignant pleural effusion: Anti‑angiogenic therapy and immunotherapy (Review).".International journal of oncology 58..3(2021):359-370
