机构：[1]Department of Medical Ultrasound, Affiliated Tumor Hospital of Guangxi Medical University, Nanning, China,[2]Departmentof Radiology, First Affiliated Hospital of Guangxi Medical University, Nanning, China,[3]Institute of Brain and PsychologicalSciences, Sichuan Normal University, Chengdu, China,[4]Department of Radiology, Seventh Affiliated Hospital of Sun Yat-senUniversity, Shenzhen, China,深圳市康宁医院深圳医学信息中心中国医学科学院阜外医院深圳医院[5]Department of Otorhinolaryngology Head and Neck Surgery, First Affiliated Hospitalof Guangxi Medical University, Nanning, China,[6]Department of Diagnostic Radiology, City of Hope National Medical Center,Duarte, CA, United States
Background: Brain functional alterations have been observed in children with congenital sensorineural hearing loss (CSNHL). The purpose of this study was to assess the alterations of regional homogeneity in children with CSNHL.</p> Methods: Forty-five children with CSNHL and 20 healthy controls were enrolled into this study. Brain resting-state functional MRI (rs-fMRI) for regional homogeneity including the Kendall coefficient consistency (KCC-ReHo) and the coherence-based parameter (Cohe-ReHo) was analyzed and compared between the two groups, i.e., the CSNHL group and the healthy control group.</p> Results: Compared to the healthy controls, children with CSNHL showed increased Cohe-ReHo values in left calcarine and decreased values in bilateral ventrolateral prefrontal cortex (VLPFC) and right dorsolateral prefrontal cortex (DLPFC). Children with CSNHL also had increased KCC-ReHo values in the left calcarine, cuneus, precentral gyrus, and right superior parietal lobule (SPL) and decreased values in the left VLPFC and right DLPFC. Correlations were detected between the ReHo values and age of the children with CSNHL. There were positive correlations between ReHo values in the pre-cuneus/pre-frontal cortex and age (p < 0.05). There were negative correlations between ReHo values in bilateral temporal lobes, fusiform gyrus, parahippocampal gyrus and precentral gyrus, and age (p < 0.05).</p> Conclusion: Children with CSNHL had RoHo alterations in the auditory, visual, motor, and other related brain cortices as compared to the healthy controls with normal hearing. There were significant correlations between ReHo values and age in brain regions involved in information integration and processing. Our study showed promising data using rs-fMRI ReHo parameters to assess brain functional alterations in children with CSNHL.</p>
基金：
Natural Science Foundation of Guangxi, P.R. ChinaNational Natural Science Foundation of Guangxi Province [2020GXNSFAA259047]; Basic Ability Enhancement Program for Young and Middle-aged Teachers of Guangxi, P.R. China [2020KY03035]; Clinical Research Climbing Program of the First Affiliated Hospital of Guangxi Medical University, P.R. China [YYZS2020021]
第一作者机构：[1]Department of Medical Ultrasound, Affiliated Tumor Hospital of Guangxi Medical University, Nanning, China,
共同第一作者：
通讯作者：
推荐引用方式(GB/T 7714)：
Guo Pingping,Lang Siyuan,Jiang Muliang,et al.Alterations of Regional Homogeneity in Children With Congenital Sensorineural Hearing Loss: A Resting-State fMRI Study[J].FRONTIERS IN NEUROSCIENCE.2021,15:doi:10.3389/fnins.2021.678910.
APA：
Guo, Pingping,Lang, Siyuan,Jiang, Muliang,Wang, Yifeng,Zeng, Zisan...&Chen, Bihong T..(2021).Alterations of Regional Homogeneity in Children With Congenital Sensorineural Hearing Loss: A Resting-State fMRI Study.FRONTIERS IN NEUROSCIENCE,15,
MLA：
Guo, Pingping,et al."Alterations of Regional Homogeneity in Children With Congenital Sensorineural Hearing Loss: A Resting-State fMRI Study".FRONTIERS IN NEUROSCIENCE 15.(2021)
