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Nicotinamide mononucleotide attenuates doxorubicin-induced cardiotoxicity by reducing oxidative stress, inflammation and apoptosis in rats.

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收录情况： ◇ SCIE

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机构： [1]Department of Radiology, West China Hospital, Sichuan University, Chengdu, China. [2]Molecular Imaging Center, West China Hospital, Sichuan University, Chengdu, China. [3]Basic Medical School, Yunnan University of Chinese Medicine, Kunming, China. [4]The First Affiliated Hospital of Chengdu Medical College, Chengdu, China. [5]Sichuan Cancer Hospital and Institute, Sichuan Cancer Center, School of Medicine, University of Electronic Science and Technology of China, Radiation Oncology Key Laboratory of Sichuan Province, China

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Doxorubicin (DOX) is an effective and widely used antineoplastic drug. However, its clinical application is limited due to its dose-dependent cardiotoxicity. Great efforts have been made to explore the pathological mechanism of DOX-induced cardiotoxicity (DIC), but new drugs and strategies to alleviate cardiac damage are still needed. Here, we aimed to investigate the effect of nicotinamide mononucleotide (NMN) on DIC in rats. The results of the present study showed that DOX treatment significantly induced cardiac dysfunction and cardiac injury, whereas NMN alleviated these changes. In addition, NMN inhibited Dox-induced activation of nucleotide-binding domain-like receptor protein 3 (NLRP3) inflammasome-mediated inflammation, as evidenced by decreased caspase 1 and IL-1β activity. Moreover, NMN treatment increased glutathione (GSH) levels and superoxide dismutase (SOD) activity and decreased the levels of malondialdehyde (MDA) and reactive oxygen species (ROS) in DOX-treated rats. Furthermore, NMN treatment mitigated DOX-induced cardiomyocyte apoptosis and cardiac fibrosis. In conclusion, the results indicated that NMN protects against DIC in rats by inhibiting NLRP3 inflammasome activation, oxidative stress, and apoptosis.Copyright © 2021. Published by Elsevier Inc.

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出版当年[2021]版：

大类 | 3 区生物学

小类 | 3 区生物物理 4 区生化与分子生物学

最新[2023]版：

大类 | 3 区生物学

小类 | 2 区生物物理 3 区生化与分子生物学

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出版当年[2021]版：

Q2 BIOPHYSICS Q3 BIOCHEMISTRY & MOLECULAR BIOLOGY

最新[2023]版：

Q1 BIOPHYSICS Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY

影响因子： 3.8 最新[2023版] 3.8 最新五年平均 4.114 出版当年[2021版] 4.27 出版当年五年平均 4.013 出版前一年[2020版] 3.9 出版后一年[2022版]

第一作者：

第一作者机构： [1]Department of Radiology, West China Hospital, Sichuan University, Chengdu, China.

通讯作者：

通讯机构： [1]Department of Radiology, West China Hospital, Sichuan University, Chengdu, China. [*1]Department of Radiology, West China Hospital, Sichuan University, No. 37 Guoxue Road, Chengdu 610041, China

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