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The epidemiology, pathophysiological mechanisms, and management toward COVID-19 patients with Type 2 diabetes: A systematic review.

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机构： [a]International Institute of Spatial Lifecourse Epidemiology (ISLE), Wuhan University, Wuhan, China [b]West China School of Public Health and West China Fourth Hospital, Sichuan University, Chengdu, China [c]Carver College of Medicine, University of Iowa, Iowa City, IA, USA [d]National Clinical Research Center of Geriatrics, Geriatric Medicine Center, West China Hospital, Sichuan University, Chengdu, Sichuan, China [e]School of Population Medicine and Public Health, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China [f]Department of Breast Surgical Oncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy ofMedical Sciences and Peking Union Medical College, Beijing, China [g]School of Resources and Environmental Science, Wuhan University, Wuhan, Chinaa

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This review comprehensively summarizes epidemiologic evidence of COVID-19 in patients with Type 2 diabetes, explores pathophysiological mechanisms, and integrates recommendations and guidelines for patient management. We found that diabetes was a risk factor for diagnosed infection and poor prognosis of COVID-19. Patients with diabetes may be more susceptible to adverse outcomes associated with SARS-CoV-2 infection due to impaired immune function and possible upregulation of enzymes that mediate viral invasion. The chronic inflammation caused by diabetes, coupled with the acute inflammatory reaction caused by SARS-CoV-2, results in a propensity for inflammatory storm. Patients with diabetes should be aware of their increased risk for COVID-19.Copyright © 2021 Primary Care Diabetes Europe. Published by Elsevier Ltd. All rights reserved.

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出版当年[2021]版：

大类 | 4 区医学

小类 | 4 区内分泌学与代谢 4 区初级卫生保健

最新[2023]版：

大类 | 4 区医学

小类 | 3 区初级卫生保健 4 区内分泌学与代谢

第一作者：

第一作者机构： [a]International Institute of Spatial Lifecourse Epidemiology (ISLE), Wuhan University, Wuhan, China [b]West China School of Public Health and West China Fourth Hospital, Sichuan University, Chengdu, China

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通讯作者：

通讯机构： [a]International Institute of Spatial Lifecourse Epidemiology (ISLE), Wuhan University, Wuhan, China [b]West China School of Public Health and West China Fourth Hospital, Sichuan University, Chengdu, China [g]School of Resources and Environmental Science, Wuhan University, Wuhan, Chinaa [*1]West China School of Public Health and West ChinaFourth Hospital, Sichuan University, Chengdu, China [*2]School of Resources and Environmental Science,Wuhan University, Wuhan, China.

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