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Cardiovascular mortality among cancer survivors who developed breast cancer as a second primary malignancy.

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机构： [1]Laboratory of Molecular Diagnosis of Cancer, and Department of Medical Oncology, Clinical Research Center for Breast Diseases, West China Hospital, Sichuan University,Chengdu, Sichuan, P. R. China [2]Sichuan Cancer Hospital & Institute, Sichuan Cancer Center, School of Medicine, University of Electronic Science and Technology of China,Chengdu, China [3]Institute of Environmental Medicine, Karolinska Institute, Stockholm, Sweden [4]Department of Medicine, Roswell Park Cancer Institute, Buffalo, NY, USA [5]ClinicalEpidemiology and Biostatistics, School of Medical Sciences, Örebro University, 701 85 Örebro, Sweden [6]Department of Epidemiology, Harvard T.H. Chan School of Public Health,677 Huntington Avenue, Boston, MA, USA. [7]Department of Population Health Sciences, Weill Cornell Medicine, New York, NY, USA. [8]Center of Public Health Sciences, Faculty ofMedicine, University of Iceland, Sturlugata 8, 101 Reykjavik, Iceland [9]Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Nobels väg 12a, 171 77 Solna,Sweden [10]West China Biomedical Big Data Center, West China Hospital, Sichuan University, Chengdu, China.

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To assess the risk of cardiovascular mortality among cancer survivors who developed breast cancer as a second malignancy (BCa-2) compared with patients with first primary breast cancer (BCa-1) and the general population.Using the Surveillance, Epidemiology, and End Results database, we conducted a population-based cohort study including 1,024,047 BCa-1 and 41,744 BCa-2 patients diagnosed from the age 30 between 1975 and 2016, and the corresponding US female population (994,415,911 person-years; 5,403,551 cardiovascular deaths). Compared with the general population and BCa-1 patients, we calculated incidence rate ratios (IRRs) of cardiovascular deaths among BCa-2 patients using Poisson regression. To adjust for unmeasured confounders, we performed a nested, case-crossover analysis among BCa-2 patients who died from cardiovascular disease.Although BCa-2 patients had a mildly increased risk of cardiovascular mortality compared with the population (IRR 1.08) and BCa-1 patients (IRR 1.15), the association was pronounced among individuals aged 30-49 years (BCa-2 vs. population: IRR 6.61; BCa-2 vs. BCa-1: IRR 3.03). The risk elevation was greatest within the first month after diagnosis, compared with the population, but comparable with BCa-1 patients. The case-crossover analysis confirmed these results.Our findings suggest that patients with BCa-2 are at increased risk of cardiovascular mortality.© 2021. The Author(s), under exclusive licence to Springer Nature Limited.

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大类 | 1 区

医学

小类 | 2 区肿瘤学

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大类 | 1 区

医学

小类 | 2 区肿瘤学

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出版当年[2021]版：

Q1 ONCOLOGY

最新[2023]版：

Q1 ONCOLOGY

影响因子： 6.4 最新[2023版] 8.1 最新五年平均 9.082 出版当年[2021版] 8.326 出版当年五年平均 7.64 出版前一年[2020版] 8.8 出版后一年[2022版]

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第一作者机构： [1]Laboratory of Molecular Diagnosis of Cancer, and Department of Medical Oncology, Clinical Research Center for Breast Diseases, West China Hospital, Sichuan University,Chengdu, Sichuan, P. R. China [2]Sichuan Cancer Hospital & Institute, Sichuan Cancer Center, School of Medicine, University of Electronic Science and Technology of China,Chengdu, China

通讯作者：

通讯机构： [3]Institute of Environmental Medicine, Karolinska Institute, Stockholm, Sweden [6]Department of Epidemiology, Harvard T.H. Chan School of Public Health,677 Huntington Avenue, Boston, MA, USA. [10]West China Biomedical Big Data Center, West China Hospital, Sichuan University, Chengdu, China.

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