机构：[1]Liver Transplantation Division, Department of Liver Surgery and Laboratory of Liver Surgery, West China Hospital, Sichuan University, Chengdu, Sichuan, China.四川大学华西医院[2]Department of Bioengineering and Therapeutic Sciences and Liver Center, University of California, San Francisco, California, USA.[3]Institute of Pathology, University of Regensburg, Regensburg, Germany.
: Hepatocellular carcinoma (HCC) is a malignant liver tumor characterized by high molecular heterogeneity, which has hampered the development of effective targeted therapies severely. Recent experimental data have unraveled novel promising targets for HCC treatment.: Eligible articles were retrieved from PubMed and Web of Science databases up to July 2021. This review summarizes the established targeted therapies for advanced HCC, focusing on the strategies to overcome drug resistance and the search for combinational treatments. In addition, conventional biomarkers holding the promises for HCC treatments and novel therapeutic targets from the research field are discussed.: HCC is a molecularly complex disease, with several and distinct pathways playing critical roles in different tumor subtypes. Experimental models recapitulating the features of each tumor subset would be highly beneficial to design novel and more effective therapies against this disease. Furthermore, a deeper understanding of combinatorial drug synergism and the role of the tumor microenvironment in HCC will lead to improved therapeutic outcomes.
语种：
外文
PubmedID：
中科院(CAS)分区：
出版当年[2021]版：
大类|2 区医学
小类|2 区药学
最新[2023]版：
大类|2 区医学
小类|2 区药学
第一作者：
第一作者机构：[1]Liver Transplantation Division, Department of Liver Surgery and Laboratory of Liver Surgery, West China Hospital, Sichuan University, Chengdu, Sichuan, China.[2]Department of Bioengineering and Therapeutic Sciences and Liver Center, University of California, San Francisco, California, USA.
通讯作者：
推荐引用方式(GB/T 7714)：
Wang Haichuan,Chen Xin,Calvisi Diego F.Hepatocellular carcinoma (HCC): the most promising therapeutic targets in the preclinical arena based on tumor biology characteristics.[J].Expert opinion on therapeutic targets.2021,25(8):645-658.doi:10.1080/14728222.2021.1976142.
APA：
Wang Haichuan,Chen Xin&Calvisi Diego F.(2021).Hepatocellular carcinoma (HCC): the most promising therapeutic targets in the preclinical arena based on tumor biology characteristics..Expert opinion on therapeutic targets,25,(8)
MLA：
Wang Haichuan,et al."Hepatocellular carcinoma (HCC): the most promising therapeutic targets in the preclinical arena based on tumor biology characteristics.".Expert opinion on therapeutic targets 25..8(2021):645-658
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