机构：[1]Sichuan Cancer Hospital & Institute, Sichuan Cancer Center, School of Medicine, University of Electronic Science and Technology of China, Radiation Oncology Key Laboratory of Sichuan Province, Chengdu, China四川省人民医院四川省肿瘤医院
This study aimed to quantify the effect of the dwell time deviation constraint (DTDC) on brachytherapy treatment for cervical cancer.A retrospective study was carried out on 20 patients with radical cervical cancer. The DTDC values changed from 0.0 to 1.0 by a step size of 0.2. We adjusted the optimization objectives to ensure that all plans were optimized to a high-risk clinical target volume (HRCTV) D90 (the dose to 90% of the HRCTV) = 6 Gy, while keeping the dose to the organs at risk as low as possible. The dose-volume histogram parameters and the dwell time data were compared between plans with different DTDC values.The HRCTV volume covered by 150% of the prescription dose gradually increased with increasing DTDC values. As the DTDC value increased from 0.0 to 1.0, the effective dwell point proportion increased from 61.78% to 90.30%. The mean dwell time initially decreased with an increase in the DTDC value, reached the minimum value at DTDC = 0.8, then slightly increased at DTDC = 1.0.When using inverse planning simulated annealing optimization for radical cervical cancer cases, the recommended DTDC value is approximately 0.6 if the organ dose needs to be limited.
基金：
Chengdu Science and
Technology Program (2019-YF09-00095-SN,
2019-YF05-00425-SN) and the Sichuan Science
and Technology Program (2019YJ0581,
2021YFG0320).
语种：
外文
被引次数：
WOS：
PubmedID：
中科院(CAS)分区：
出版当年[2021]版：
大类|4 区医学
小类|4 区医学：研究与实验4 区药学
最新[2023]版：
大类|4 区医学
小类|4 区医学：研究与实验4 区药学
JCR分区：
出版当年[2021]版：
Q4MEDICINE, RESEARCH & EXPERIMENTALQ4PHARMACOLOGY & PHARMACY
最新[2023]版：
Q4MEDICINE, RESEARCH & EXPERIMENTALQ4PHARMACOLOGY & PHARMACY
第一作者机构：[1]Sichuan Cancer Hospital & Institute, Sichuan Cancer Center, School of Medicine, University of Electronic Science and Technology of China, Radiation Oncology Key Laboratory of Sichuan Province, Chengdu, China
通讯作者：
通讯机构：[1]Sichuan Cancer Hospital & Institute, Sichuan Cancer Center, School of Medicine, University of Electronic Science and Technology of China, Radiation Oncology Key Laboratory of Sichuan Province, Chengdu, China[*1]Sichuan Cancer Hospital & Institute, Sichuan Cancer Center, School of Medicine, University of Electronic Science and Technology of China, Radiation Oncology Key Laboratory of Sichuan Province, No. 55, the 4th Section, Renmin South Road, Chengdu 610041, China.
推荐引用方式(GB/T 7714)：
Yan Gaoshu,Kang Shengwei,Tang Bin,et al.Effect of the dwell time deviation constraint on brachytherapy treatment planning for cervical cancer.[J].JOURNAL OF INTERNATIONAL MEDICAL RESEARCH.2021,49(8):doi:10.1177/03000605211037477.
APA：
Yan Gaoshu,Kang Shengwei,Tang Bin,Li Jie,Wang Pei...&Lang Jinyi.(2021).Effect of the dwell time deviation constraint on brachytherapy treatment planning for cervical cancer..JOURNAL OF INTERNATIONAL MEDICAL RESEARCH,49,(8)
MLA：
Yan Gaoshu,et al."Effect of the dwell time deviation constraint on brachytherapy treatment planning for cervical cancer.".JOURNAL OF INTERNATIONAL MEDICAL RESEARCH 49..8(2021)
