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Cyclin E in normal physiology and disease states.

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机构： [1]Department of Cancer Biology, Dana- Farber Cancer Institute, Department of Genetics, Blavatnik Institute, Harvard Medical School, Boston, MA 02215, USA [2]Sichuan Provincial Key Laboratory for Human Disease Gene Study, Sichuan Academy of Medical Sciences, Sichuan Provincial People's Hospital, University of Electronic Science and Technology, Chengdu, China

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E-type cyclins, collectively called cyclin E, represent key components of the core cell cycle machinery. In mammalian cells, two E-type cyclins, E1 and E2, activate cyclin-dependent kinase 2 (CDK2) and drive cell cycle progression by phosphorylating several cellular proteins. Abnormally elevated activity of cyclin E-CDK2 has been documented in many human tumor types. Moreover, cyclin E overexpression mediates resistance of tumor cells to various therapeutic agents. Recent work has revealed that the role of cyclin E extends well beyond cell proliferation and tumorigenesis, and it may regulate a diverse array of physiological and pathological processes. In this review, we discuss these various cyclin E functions and the potential for therapeutic targeting of cyclin E and cyclin E-CDK2 kinase.Copyright © 2021 Elsevier Ltd. All rights reserved.

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出版当年[2021]版中科院分区表Review为是的期刊

：

大类 | 1 区

生物学

小类 | 2 区细胞生物学

最新[2023]版

：

大类 | 1 区

生物学

小类 | 2 区细胞生物学

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出版当年[2021]版：

Q1 CELL BIOLOGY

最新[2023]版：

Q1 CELL BIOLOGY

影响因子： 13 最新[2023版] 19.5 最新五年平均 21.167 出版当年[2021版] 23.732 出版当年五年平均 20.808 出版前一年[2020版] 19 出版后一年[2022版]

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第一作者机构： [1]Department of Cancer Biology, Dana- Farber Cancer Institute, Department of Genetics, Blavatnik Institute, Harvard Medical School, Boston, MA 02215, USA

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