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Analysis of cognitive impairment in schizophrenia based on machine learning: Interaction between psychological stress and immune system.

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机构： [a]The Clinical Hospital of Chengdu Brain Science Institute, MOE Key Lab for Neuroinformation, University of Electronic Science and Technology of China, Chengdu, China [b]School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu, China [c]Chengdu Forth Provincial People’s Hospital, Chengdu Mental Health Center, Chengdu, China [d]CAS Key Laboratory of Mental Health, Institute of Psychology, Chinese Academy of Sciences, Beijing, China [e]Department of Psychology, University of Chinese Academy of Sciences, Beijing, China [f]Department of Psychiatry, Faculty of Medicine & Dentistry, University of Alberta, Canada [g]Sichuan Kelun Pharmaceutical CO., LTD., China

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The interaction between psychological stress and immune system may be associated with the cognitive impairment of schizophrenia. To employ machine learning algorithms to examine patterns of stress-immune networks with cognitive impairment in chronic schizophrenia, we selected cortisol, tumor necrosis factor (TNF) - α, interleukin (IL) - 2, IL-6 and IL-8 as biochemical indices reflecting the dysfunctional response to psychological stress and immune system in patients with schizophrenia. Basedon 14 kinds of interactions of above five variables, we were able to classify 37 chronic schizophrenia patients and 35 age and gender-matched healthy controls by using decision tree (DT) (Accuracy = 93.1%, Sensitivity = 97.3%, Specificity = 88.6%), random forest (RF) (Accuracy = 94.4%, Sensitivity = 91.9%, Specificity = 97.1%) and support vector machines (SVM) (Accuracy = 98.6%, Sensitivity = 100.0%, Specificity = 97.1%), which indicating that cortisol × TNF-α × IL-8 was the top risk factor for identifying chronic schizophrenia. Furthermore, we found that cortisol × TNF-α × IL-8 was positively correlated with PANSS cognitive subscore. Multiple stepwise linear regression analysis confirmed that PANSS cognitive subscore was correlated with duration of illness and cortisol × TNF-α × IL-8. The results suggest that the glucocorticoid-immune relationship may have an effect on the cognitive impairment of patients.Copyright © 2021 Elsevier B.V. All rights reserved.

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出版当年[2021]版：

大类 | 4 区医学

小类 | 4 区神经科学

最新[2023]版：

大类 | 4 区医学

小类 | 4 区神经科学

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第一作者机构： [a]The Clinical Hospital of Chengdu Brain Science Institute, MOE Key Lab for Neuroinformation, University of Electronic Science and Technology of China, Chengdu, China [b]School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu, China [c]Chengdu Forth Provincial People’s Hospital, Chengdu Mental Health Center, Chengdu, China

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通讯机构： [a]The Clinical Hospital of Chengdu Brain Science Institute, MOE Key Lab for Neuroinformation, University of Electronic Science and Technology of China, Chengdu, China [b]School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu, China [c]Chengdu Forth Provincial People’s Hospital, Chengdu Mental Health Center, Chengdu, China [d]CAS Key Laboratory of Mental Health, Institute of Psychology, Chinese Academy of Sciences, Beijing, China [e]Department of Psychology, University of Chinese Academy of Sciences, Beijing, China [*1]CAS Key Laboratory of Mental Health, Institute of Psychology, Chinese Academy of Sciences, Beijing, China [*2]The Clinical Hospital of Chengdu Brain Science Institute, MOE Key Lab for Neuroinformation, University of Electronic Science and Technology of China, Chengdu, China

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