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The immune regulatory effects of tetrahedral framework nucleic acid on human T cells via the mitogen-activated protein kinase pathway.

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机构： [1]Department of Neurosurgery, West China Hospital, Sichuan University, Chengdu, China. [2]Sichuan Cancer Hospital & Institute, Centre for Translational Research in Cancer, Sichuan Cancer Center, Chengdu, China. [3]State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, China. [4]Department of Neurology, West China Hospital, Sichuan University, Chengdu, China. [5]College of Biomedical Engineering, Sichuan University, Chengdu, China. [6]School of Medicine, University of Electronic Science and Technology of China, Chengdu, China.

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Autoimmune diseases are a heterogeneous group of diseases which lose the immunological tolerance to self-antigens. It is well recognized that irregularly provoked T cells participate in the pathological immune responses. As a novel nanomaterial with promising applications, tetrahedral framework nucleic acid (TFNA) nanostructure was found to have immune regulatory effects on T cells in this study.To verify the successful fabrication of TFNA, the morphology of TFNA was observed by atomic force microscopy (AFM) and dynamic light scattering. The regulatory effect of TFNA was evaluated by flow cytometry after cocultured with CD3+ T cells isolated from healthy donors. Moreover, the associated signaling pathways were investigated. Finally, we verified our results on the T cells from patients with neuromyelitis optica spectrum disorder (NMOSD), which is a typical autoimmune disease induced by T cells.We revealed the alternative regulatory functions of TFNA in human primary T cells with steady status via the JNK signaling pathway. Moreover, by inhibiting both JNK and ERK phosphorylation, TFNA exhibited significant suppressive effects on IFNγ secretion from provoking T cells without affecting TNF secretion. Similar immune regulatory effects of TFNA were also observed in autoreactive T cells from patients with NMOSD.Overall, our results revealed a potential application of TFNA in regulating the adaptive immune system, as well as shed a light on the treatment of T cell-mediated autoimmune diseases.© 2021 The Authors. Cell Proliferation published by John Wiley & Sons Ltd.

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出版当年[2021]版：

大类 | 2 区生物学

小类 | 2 区细胞生物学

最新[2023]版：

大类 | 1 区

生物学

小类 | 2 区细胞生物学

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出版当年[2021]版：

Q1 CELL BIOLOGY

最新[2023]版：

Q2 CELL BIOLOGY

影响因子： 5.9 最新[2023版] 7.3 最新五年平均 8.755 出版当年[2021版] 7.834 出版当年五年平均 6.831 出版前一年[2020版] 8.5 出版后一年[2022版]

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第一作者机构： [1]Department of Neurosurgery, West China Hospital, Sichuan University, Chengdu, China.

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通讯机构： [2]Sichuan Cancer Hospital & Institute, Centre for Translational Research in Cancer, Sichuan Cancer Center, Chengdu, China. [3]State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, China. [5]College of Biomedical Engineering, Sichuan University, Chengdu, China. [6]School of Medicine, University of Electronic Science and Technology of China, Chengdu, China. [*1]State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, College of Biomedical Engineering, Sichuan University, Chengdu, 610041, China. [*2]Sichuan Cancer Hospital & Institute, Centre for Translational Research in Cancer, Sichuan Cancer Center, School of Medicine, University of Electronic Science and Technology of China, Chengdu, 610041, China.

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