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Brain changes correlate with neuropathic pain in patients with neuromyelitis optica spectrum disorders.

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机构： [1]Department of Neurology, West China Hospital, Sichuan University, Chengdu, Sichuan, China [2]Department of Neurology, Chongqing City Hospital of Traditional Chinese Medicine, Chongqing, China [3]Department of Neurology, the first Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China [4]Department of Internal Medicine, Hospital of Chengdu Office of People’s Government of Tibetan Autonomous Region, Chengdu, Sichuan, China [5]Sichuan Cancer Hospital and research Institute, Sichuan Cancer Center, School of Medicine, University of Electronic Science and Technology of China, Chengdu, China [6]Department of Computer Science, Chengdu University of Information Technology

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Neuropathic pain (NP) is a highly disturbing sensory experience in patients with neuromyelitis optica spectrum disorders (NMOSD). However, the brain changes in NMOSD patients with NP have rarely been studied.The aim of the cross-sectional and follow-up longitudinal study was to investigate the brain changes in NMOSD patients with NP.In the cross-sectional study, comparisons were performed between groups with NP (W-NP) and without NP (Wo-NP), and age, sex and years of education were adjusted. We compared the voxel-wise whole-brain gray matter (GM) volume, cortical thickness (CT), cortical surface area (CSA) and local gyrification index (LGI). Probabilistic tractography started from regions with significant between-group differences in GM volume, CT, CSA and LGI. We also compared fractional anisotropy (FA), mean diffusivity (MD), radial diffusivity (RD) and axial diffusivity (AD) of the white matter (WM) skeleton using Tract-Based Spatial Statistics (TBSS). In the longitudinal study, the patients were followed for 2.0±0.0 years and underwent the same imaging scanning as the cross-sectional study. Changes of the CT, CSA, LGI and WM were obtained.Patients in the W-NP group were older than those in the Wo-NP group and showed significantly reduced LGI of the left temporal lobe and adjacent regions(regions of interest, ROIs), which participated in neuropathic pain processing, possibly by emotion and attention control. Probabilistic tractography started from ROIs, and the generated WM tracts showed decreased MD and RD in the W-NP group compared to the Wo-NP group. Using TBSS, both MD and RD decreased in extensive WM skeleton in the right hemisphere of the patients in the W-NP group. Additionally, in the follow-up longitudinal study, compared with patients in the Wo-NP group, patients in the W-NP group showed lower mean reduction rates of LGI of ROIs, and less increase of FA and more increases of MD, AD and RD in the extensive WM skeleton.These findings support the hypothesis that brain changes might correlate with NP in NMOSD patients and predict the changes related to NP over time.Copyright © 2021. Published by Elsevier B.V.

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出版当年[2021]版：

大类 | 3 区医学

小类 | 4 区临床神经病学

最新[2023]版：

大类 | 3 区医学

小类 | 4 区临床神经病学

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出版当年[2021]版：

Q2 CLINICAL NEUROLOGY

最新[2023]版：

Q2 CLINICAL NEUROLOGY

影响因子： 2.9 最新[2023版] 3.2 最新五年平均 4.808 出版当年[2021版] 4.585 出版当年五年平均 4.339 出版前一年[2020版] 4 出版后一年[2022版]

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第一作者机构： [1]Department of Neurology, West China Hospital, Sichuan University, Chengdu, Sichuan, China

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