机构：[1]Department of Thoracic Surgery, Sichuan Cancer Hospital &Institute, Sichuan Cancer Center, School of Medicine, University of Electronic Science and Technology of China, Chengdu, China.外科中心胸外科中心四川省人民医院四川省肿瘤医院胸外科[2]Laboratory of Pathology, West China Hospital, Sichuan University, Chengdu, China.四川大学华西医院[3]Genecast Biotechnology Co., Ltd, Wuxi, China.
To identify biomarkers related to esophageal squamous cell carcinoma (ESCC) prognosis by analyzing genetic variations and the infiltration levels of tumor-infiltrating lymphocytes (TILs) in patients.
The clinical features of 61 patients with ESCC were collected. DNA panel sequencing was performed to screen differentially expressed genes (DEGs). Transcriptome sequencing was performed to identify gene expression profiles, and subsequent enrichment analysis of DEGs was conducted using Metascape.
We identified 488 DEGs between patients with ESCC with distinct prognoses that were mainly enriched in the human immune response, fibrinogen complex, and protein activation cascade pathways. Among patients with ESCC treated with postoperative chemotherapy, those with a high infiltration level of myeloid-derived suppressor cells (MDSCs) had longer overall survival (OS), and OS was positively correlated with the infiltration level of T helper type 2 (Th2) cells among patients treated without chemotherapy after surgery. Additionally, in the case of MDSCs >0.7059 or Th2 cells <0.6290, patients receiving postoperative chemotherapy had a longer OS than those treated without chemotherapy following surgery.
The level of MDSCs or Th2 cells can be used as a biomarker for assessing the prognosis of patients with ESCC treated with or without postoperative chemotherapy, respectively.
基金：
The research was supported by the Sichuan
Science and Technology Program (Grant
number 2018JY0277 and 2019JDRC0076) and
the Bethune Charitable Foundation (Grant
number 320.320.2730.1876).
语种：
外文
被引次数：
WOS：
PubmedID：
中科院(CAS)分区：
出版当年[2021]版：
大类|4 区医学
小类|4 区医学：研究与实验4 区药学
最新[2023]版：
大类|4 区医学
小类|4 区医学：研究与实验4 区药学
JCR分区：
出版当年[2021]版：
Q4MEDICINE, RESEARCH & EXPERIMENTALQ4PHARMACOLOGY & PHARMACY
最新[2023]版：
Q4MEDICINE, RESEARCH & EXPERIMENTALQ4PHARMACOLOGY & PHARMACY
第一作者机构：[1]Department of Thoracic Surgery, Sichuan Cancer Hospital &Institute, Sichuan Cancer Center, School of Medicine, University of Electronic Science and Technology of China, Chengdu, China.
共同第一作者：
通讯作者：
通讯机构：[1]Department of Thoracic Surgery, Sichuan Cancer Hospital &Institute, Sichuan Cancer Center, School of Medicine, University of Electronic Science and Technology of China, Chengdu, China.[*1]Department of Thoracic Surgery, Sichuan Cancer Hospital & Institute, Sichuan Cancer Center, School of Medicine, University of Electronic Science and Technology of China, No. 55, Section 4, South Renmin Road, Chengdu 610041, China.
推荐引用方式(GB/T 7714)：
Peng Lin,He Wenwu,Ye Feng,et al.Identification of tumor-infiltrating lymphocyte subpopulations correlated with patient prognosis in esophageal squamous cell carcinoma.[J].JOURNAL OF INTERNATIONAL MEDICAL RESEARCH.2021,49(5):doi:10.1177/03000605211016206.
APA：
Peng Lin,He Wenwu,Ye Feng,Song Yane,Shi Xinying...&Han Yongtao.(2021).Identification of tumor-infiltrating lymphocyte subpopulations correlated with patient prognosis in esophageal squamous cell carcinoma..JOURNAL OF INTERNATIONAL MEDICAL RESEARCH,49,(5)
MLA：
Peng Lin,et al."Identification of tumor-infiltrating lymphocyte subpopulations correlated with patient prognosis in esophageal squamous cell carcinoma.".JOURNAL OF INTERNATIONAL MEDICAL RESEARCH 49..5(2021)
