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The mutual regulatory loop between TPTEP1 and miR-1303 in leukemogenesis of acute myeloid leukemia(Open Access)

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机构： [1]Department of Lymphoma, Sichuan Cancer Hospital & Institute, Sichun Cancer Center, School of Medicine, University of Electronic Science and Technology of China, No.55, Section 4, South Renmin Road, Chendu 610041, Sichuan, China. [2]Food Nutrition Center, West China Hospital, Sichun University, No.37, Guoxue Xiang, Wuhou District, Chendu 610041, Sichuan, China

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关键词： AML JNK/c-JUN Leukemogenesis MiR-1303 TPTEP1

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Background: Non-coding RNAs (ncRNAs) have been identified as key regulators during the pathogenesis and development of cancers. However, most of ncRNAs have never been explored in acute myeloid leukemia (AML). Methods: Gene expression was evaluated by quantitative real-time polymerase chain reaction (qRT-PCR) or western blot. Functional assays were performed to assess the cellular processes in AML cells. The relationship between genes was verified by means of a series of mechanism assays. Results: Transmembrane phosphatase with tensin homology pseudogene 1 (TPTEP1) was notably downregulated in AML cells, and functionally acted as a proliferation-inhibitor. Additionally, TPTEP1 suppressed AML cell growth by inactivating c-Jun N-terminal kinase (JNK)/c-JUN signaling pathway. MicroRNA (MiR)-1303, as an oncogene, was predicted and validated as a target of c-JUN in AML cells. Also, TPTEP1 interacted with miR-1303 and they were mutually silenced by each other in AML cells. Furthermore, the effect of TPTEP1 overexpression on AML cell proliferation was counteracted under miR-1303 upregulation. Conclusion: Our findings unmasked a feedback loop of TPTEP1/JNK/c-JUN/miR-1303 axis in AML cells, suggesting TPTEP1 and miR-1303 as potential targets for developing therapeutic strategies for AML patients. [Figure not available: see fulltext.] © 2021, The Author(s).

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出版当年[2021]版：

大类 | 3 区医学

小类 | 3 区肿瘤学

最新[2023]版：

大类 | 2 区医学

小类 | 3 区肿瘤学

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Q2 ONCOLOGY

最新[2023]版：

Q1 ONCOLOGY

影响因子： 5.3 最新[2023版] 5 最新五年平均 6.435 出版当年[2021版] 5.999 出版当年五年平均 5.722 出版前一年[2020版] 5.8 出版后一年[2022版]

第一作者：

第一作者机构： [1]Department of Lymphoma, Sichuan Cancer Hospital & Institute, Sichun Cancer Center, School of Medicine, University of Electronic Science and Technology of China, No.55, Section 4, South Renmin Road, Chendu 610041, Sichuan, China.

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