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Surgery Treatment Improved the Overall Survival Rate in Locoregional Myxoid Leiomyosarcoma than Other Myxosarcomas in the United States(Open Access)

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机构： [1]Key Lab of Aromatic Plant Resources Exploitation and Utilization in Sichuan Higher Education, Yibin University, Yibin,644000 Sichuan, China [2]Department of Pharmacology, Pharmaceutical College, Dalian Medical University, Dalian 116044, China [3]Department of Urology, First Affiliated Hospital of Dalian Medical University, Dalian 116044, China [4]Department of Oncology, First Affiliated Hospital of Dalian Medical University, Dalian 116044, China [5]Department of Urology, Second Affiliated Hospital of Dalian Medical University, Dalian 116044, China [6]Department of Immunology, Guangzhou Institute of Pediatrics, Guangzhou Women and Children’s Medical Center,Guangzhou Medical University, Guangzhou 510623, China [7]Guangdong Cardiovascular Institute, Guangdong Provincial People’s Hospital, Guangdong Academy of Medical Sciences,Guangzhou, Guangdong 510100, China [8]Department of Pharmacology and Pharmacotherapy, Faculty of Medicine, Interdisciplinary Excellence Center, University of Szeged,Szeged 6720, Hungary [9]Department of Pharmacology, School of Basic Medical Sciences, Xi’an Jiaotong University, Health Science Center,Xi’an 710061, China

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Myxosarcomas are rare malignant tumors of soft connective tissues, classified into various subtypes, including myxoid liposarcoma, myxoid chondrosarcoma, and myxoid leiomyosarcoma. In this study, we proposed to study the demographic, tumor characteristics, and overall survival rate and compared the treatment modalities between these cancers. Patient data collected based on locoregional metastasis presentation of the abovementioned tumors with a cutoff study of survival duration up to 10 years were obtained from the SEER database during 1975-2016. Our results indicated that elderly patients and females were more in locoregional myxoid leiomyosarcoma than myxoid liposarcoma and myxoid chondrosarcoma with locoregional metastasis. The white race represented the most patients who suffered from these cancers than other races. The heart is the primary site for the abovementioned cancers, in addition to the female genitals to the myxoid leiomyosarcoma. Myxoid liposarcoma and myxoid chondrosarcoma patients with locoregional metastasis were suffering from grade II, while locoregional myxoid leiomyosarcoma patients with blank grading were due to missed data. Surgery was the most common treatment modality in this study compared with radiotherapy and chemotherapy. Kaplan-Meier analysis showed a significant difference in survival time between the three subtypes by using histology, and myxoid leiomyosarcoma showed prolonged survival than others. Elderly, female, white, unknown grade, surgery, no radiation, and no chemotherapy variables were independent factors associated with overall survival among these cancers. Multivariate analysis also showed significant differences in overall survival between the three tumors by histology, and myxoid leiomyosarcoma was with a better prognosis than others. Multivariate analysis of locoregional myxoid leiomyosarcoma showed the statistical significance of black race, grade, and radiotherapy, indicating them as independent prognostic factors of locoregional myxoid leiomyosarcoma. We conclude that surgery was the primary treatment modality against these cancers than radiotherapy and chemotherapy. And the locoregional myxoid leiomyosarcomas showed a better prognosis and higher survival rate than locoregional myxoid liposarcoma and locoregional myxoid chondrosarcoma. © 2021 Marwan Almoiliqy et al.

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大类 | 2 区生物学

小类 | 3 区细胞生物学

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Q2 CELL BIOLOGY

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影响因子： 0 最新[2023版] 0 最新五年平均 7.31 出版当年[2021版] 8.427 出版当年五年平均 6.543 出版前一年[2020版]

第一作者：

第一作者机构： [1]Key Lab of Aromatic Plant Resources Exploitation and Utilization in Sichuan Higher Education, Yibin University, Yibin,644000 Sichuan, China [2]Department of Pharmacology, Pharmaceutical College, Dalian Medical University, Dalian 116044, China

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通讯作者：

通讯机构： [1]Key Lab of Aromatic Plant Resources Exploitation and Utilization in Sichuan Higher Education, Yibin University, Yibin,644000 Sichuan, China [2]Department of Pharmacology, Pharmaceutical College, Dalian Medical University, Dalian 116044, China

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