机构：[1]Department of Epidemiology and Health Statistics, West China School of Public Health and West China Fourth Hospital, Sichuan University, Chengdu 610041, Sichuan, China.[2]Department of Pharmacy, West China Second University Hospital, Sichuan University, Chengdu 610041, Sichuan, China.[3]Department of Clinical Research Management, West China Hospital, Sichuan University, Chengdu 610041, Sichuan, China.四川大学华西医院[4]Institute of Clinical Pathology, West China Hospital, Sichuan University, Chengdu 610041, Sichuan, Chin四川大学华西医院
There is strong evidence to suggest that obesity-related proteins play a key role in pathways that are related to breast cancer. In this study, we aimed to establish a robust obesity-related protein score (ORPS) that could be used to assess breast cancer risk. Based on evidence from high-quality systematic reviews and population studies, we selected nine such proteins that are stable in vitro, and measured their circulating concentrations by ELISA in a case-control study conducted in Chengdu, Sichuan, China, with 279 breast cancer cases and 260 healthy controls. Two obesity-related protein scores (ORPS) were calculated using a three-step method, with linear-weighted summation, and the one with a larger area under the curve was chosen for further evaluation. As a result, ORPS (PS5pre or PS4post) was positively correlated with breast cancer risk (premenopausal: OR≤63 VS >63 3.696, 95% CI 2.025-6.747; postmenopausal: OR≤38 VS >38 7.100, 95% CI 3.134-16.084), and represented a better risk predictor among obese women compared to non-obese in pre- and postmenopausal women. Among different molecular subtypes, ORPS was positively correlated with Luminal breast cancer, with additionally positive association with triple-negative breast cancer in premenopausal women. The ORPS might be a potential marker of breast cancer risk among Chinese women.
基金：
Tis study was funded by the Grants from the National Natural Science Foundation of China (No. 81874282)
and was also supported by the Project of Sichuan Provincial Health Commission on breast cancer among urban
women (No. 20PJ093), as well as the Disciplines of Excellence-Clinical Research Incubation Project, West China
Hospital, Sichuan University (No. 2020HXFH009).
语种：
外文
PubmedID：
中科院(CAS)分区：
出版当年[2021]版：
大类|3 区综合性期刊
小类|3 区综合性期刊
最新[2023]版：
大类|2 区综合性期刊
小类|2 区综合性期刊
第一作者：
第一作者机构：[1]Department of Epidemiology and Health Statistics, West China School of Public Health and West China Fourth Hospital, Sichuan University, Chengdu 610041, Sichuan, China.[2]Department of Pharmacy, West China Second University Hospital, Sichuan University, Chengdu 610041, Sichuan, China.
共同第一作者：
通讯作者：
推荐引用方式(GB/T 7714)：
Diao Sha,Wu Xueyao,Zhang Xiaofan,et al.Obesity-related proteins score as a potential marker of breast cancer risk.[J].Scientific reports.2021,11(1):8230.doi:10.1038/s41598-021-87583-3.
APA：
Diao Sha,Wu Xueyao,Zhang Xiaofan,Hao Yu,Xu Bin...&Li Jiayuan.(2021).Obesity-related proteins score as a potential marker of breast cancer risk..Scientific reports,11,(1)
MLA：
Diao Sha,et al."Obesity-related proteins score as a potential marker of breast cancer risk.".Scientific reports 11..1(2021):8230
