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The role of Fibrinogen-like proteins in Cancer.

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机构： [1]Laboratory of Molecular Pharmacology, Department of Pharmacology, School of Pharmacy, Southwest Medical University, Luzhou, Sichuan, China. [2]South Sichuan Institute of Translational Medicine, Luzhou, Sichuan, China. [3]Department of Oncology and Hematology, Hospital (T.C.M) Affiliated to Southwest Medical University, Luzhou, Sichuan, China. [4]Department of Pharmacy, The Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan, China.

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关键词： FGF1 FGF2 Cancer

摘要：

Fibrinogen-associated protein (FREP) family is a family of proteins with a fibrin domain at the carboxyl terminus. Recent investigations illustrated that two members of FREP family, fibrinogen-like protein-1 (FGL1) and fibrinogen-like protein-2 (FGL2), play crucial roles in cancer by regulating the proliferation, invasion, and migration of tumor cells, or regulating the functions of immune cells in tumor microenvironment. Meanwhile, they are potential targets for medical intervention of tumor development. In this review, we discussed the structure, and the roles of FGL1 and FGL2 in tumors, especially the roles in regulating immune cell functions. © The author(s).

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出版当年[2021]版：

大类 | 2 区生物学

小类 | 2 区生化与分子生物学

最新[2025]版：

大类 | 1 区

生物学

小类 | 2 区生化与分子生物学

第一作者：

第一作者机构： [1]Laboratory of Molecular Pharmacology, Department of Pharmacology, School of Pharmacy, Southwest Medical University, Luzhou, Sichuan, China. [2]South Sichuan Institute of Translational Medicine, Luzhou, Sichuan, China.

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通讯作者：

通讯机构： [1]Laboratory of Molecular Pharmacology, Department of Pharmacology, School of Pharmacy, Southwest Medical University, Luzhou, Sichuan, China. [2]South Sichuan Institute of Translational Medicine, Luzhou, Sichuan, China. [4]Department of Pharmacy, The Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan, China. [*1]Laboratory of Molecular Pharmacology, Department of Pharmacology, School of Pharmacy, Southwest Medical University [*2]South Sichuan Institute of Translational Medicine [*3]Department of Pharmacy, The Affiliated Hospital of Southwest Medical University,Luzhou, Sichuan 646000, China

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