机构：[1]Department of Medical Laboratory, West China Second University Hospital, Sichuan University, 610041 ChengDu, China[2]Key Laboratory of Obstetric & Gynecologic and Pediatric Diseases and Birth Defects of Ministry of Education, 610041 ChengDu, China[3]Institute of Health Policy & Hospital Management, Sichuan Provincial People’s Hospital, University of Electronic Science and Technology of China, Chengdu, China四川省人民医院[4]Chinese Academy of Sciences Sichuan Translational Medicine Research Hospital, 610072 ChengDu, China四川省人民医院
The present study attempted to analyse human papillomavirus (HPV) genotype distribution
and its association with cervical cytology results in women in western China. The present
retrospective analysis was performed in 1089 female outpatients with a positive HPV test
result who had undergone a cervical cytology test at the gynaecological clinic, West China
Second Hospital, Sichuan University, China, between January 2014 and December 2016. Of
the 1089 patients with HPV infection, multiple HPV genotypes were detected in 220 patients
(20.20%). Among the 1368 HPV genotypes detected, 1145 (83.70%) were high-risk subtypes.
The most common genotypes were HPV-52 (18.64%), HPV-16 (16.59%), HPV-58 (13.23%),
HPV-18 (6.80%), HPV-56 (5.56%) and HPV-59 (5.56%). Cervical cytology revealed abnormal
cells in 430 (39.49%) patients. The most common diagnoses were atypical squamous cells of
undetermined significance (ASC-US; 236 cases, 54.88%), low-grade squamous intraepithelial
lesions (LSIL; 151 cases, 35.12%), high-grade squamous intraepithelial lesions (HSIL; 63 cases,
14.65%) and atypical glandular cells (AGC; 21 cases, 4.88%). HPV-66 was significantly
associated (P = 0.037) with ASC; HPV-52 and HPV-56 were significantly associated with
LSIL (P = 0.009 and 0.026, respectively); HPV-16 (P < 0.001), HPV-33 (P = 0.014) and
HPV-58 (P = 0.003) were significantly associated with HSIL; and HPV-16 (P = 0.005) was significantly
associated with AGC. HPV-16, HPV-52 and HPV-58 are associated with different
diagnoses in patients with positive cervical cytological findings.
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外文
被引次数：
WOS：
PubmedID：
中科院(CAS)分区：
出版当年[2021]版：
大类|4 区医学
小类|4 区公共卫生、环境卫生与职业卫生4 区传染病学
最新[2023]版：
大类|4 区医学
小类|4 区传染病学4 区公共卫生、环境卫生与职业卫生
JCR分区：
出版当年[2021]版：
Q2INFECTIOUS DISEASESQ2PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH
第一作者机构：[1]Department of Medical Laboratory, West China Second University Hospital, Sichuan University, 610041 ChengDu, China[2]Key Laboratory of Obstetric & Gynecologic and Pediatric Diseases and Birth Defects of Ministry of Education, 610041 ChengDu, China
共同第一作者：
通讯作者：
通讯机构：[1]Department of Medical Laboratory, West China Second University Hospital, Sichuan University, 610041 ChengDu, China[2]Key Laboratory of Obstetric & Gynecologic and Pediatric Diseases and Birth Defects of Ministry of Education, 610041 ChengDu, China[3]Institute of Health Policy & Hospital Management, Sichuan Provincial People’s Hospital, University of Electronic Science and Technology of China, Chengdu, China[4]Chinese Academy of Sciences Sichuan Translational Medicine Research Hospital, 610072 ChengDu, China
推荐引用方式(GB/T 7714)：
Liu Fang,Chang Li,Bai Ting,et al.Association of Human Papillomavirus Genotype Distribution and Cervical Cytology: A Cross-sectional Study.[J].EPIDEMIOLOGY AND INFECTION.2021,149:doi:10.1017/S0950268821000741.
APA：
Liu Fang,Chang Li,Bai Ting,Liu Xiaojuan&Hu Jinliang.(2021).Association of Human Papillomavirus Genotype Distribution and Cervical Cytology: A Cross-sectional Study..EPIDEMIOLOGY AND INFECTION,149,
MLA：
Liu Fang,et al."Association of Human Papillomavirus Genotype Distribution and Cervical Cytology: A Cross-sectional Study.".EPIDEMIOLOGY AND INFECTION 149.(2021)
