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Excision margin of T3 basal cell carcinoma in maxillofacial area: A retrospective cohort study of Asians.

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机构： [1]Department of Oral & Maxillofacial-Head & Neck Oncology, Shanghai Ninth People's Hospital, College of Stomatology, Shanghai Jiao Tong University School of Medicine, Shanghai, China. [2]National Clinical Research Center for Oral Diseases, Shanghai, China. [3]Shanghai Key Laboratory of Stomatology Shanghai Research Institute of Stomatology, Shanghai, China. [4]Department of Oral and Maxillofacial Surgery, State Key Laboratory of Oral Diseases, West China Hospital of Stomatology (Sichuan University), Sichuan, China.

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Basal cell carcinoma is the most common skin cancer worldwide. Surgical excision is considered as the mainstay of treatment, while the evidence of excision margin in advanced stage is lacking, especially in maxillofacial area. We conducted a 2-center retrospective cohort study. Disease-free survival rate was estimated for 116 Asian patients with T3 basal cell carcinoma in maxillofacial area who received stand surgical excision with margin of 3-5 mm (Group A), 6-9 mm (Group B), and 10-15 mm (Group C). For the entire cohort, five-year disease-free survival rates of Groups A, B, and C were 82.1%, 93.5%, and 92.4%, respectively. When compared with Group B, Group A was correlated with lower disease-free survival rate (HR 5.48, p = .04), and Group C was not associated with different disease-free survival rate (HR 0.85, p = .62). Perineural invasion (p = .006) and pathologic subtypes of infiltrative basal cell carcinoma (p = .01) were independent prognosticator for disease-free survival rate. This multicenter cohort study validated that T3 basal cell carcinoma Asian patients of maxillofacial area treated with excision margin of 6-9 mm had a substantial benefit of disease-free survival rate and skin conservation. © 2020 Wiley Periodicals LLC.

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出版当年[2022]版：

大类 | 3 区医学

小类 | 3 区牙科与口腔外科

最新[2023]版：

大类 | 3 区医学

小类 | 4 区牙科与口腔外科

第一作者：

第一作者机构： [1]Department of Oral & Maxillofacial-Head & Neck Oncology, Shanghai Ninth People's Hospital, College of Stomatology, Shanghai Jiao Tong University School of Medicine, Shanghai, China. [2]National Clinical Research Center for Oral Diseases, Shanghai, China. [3]Shanghai Key Laboratory of Stomatology Shanghai Research Institute of Stomatology, Shanghai, China.

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