机构：[1]Department of Urology, Panzhihua Central Hospital, Panzhihua City, 617067, Sichuan Province, China.[2]Department of Pediatrics, Panzhihua Central Hospital, Panzhihua City, 617067, Sichuan Province, China.[3]Department of Urology, The General Hospital of CNPC in Jilin, Jilin City, 132011, China.[4]Department of Urology, Occupational Disease Hospital of Xinjiang Uygur Autonomous Region, Urumqi City 830000, Xinjiang Uygur Autonomous Region, China.[5]Department of Urology, The Affiliated Haikou Hospital ofXiangya School of Medicine, Central South University, Haikou, 570208, Hainan Province, China.[6]Department of Urology, 948 Army Hospital, Wusu City, Tacheng District, Xinjiang, 833000, China.[7]Department of Cellular Stress Biology, Roswell Park Cancer Institute, Buffalo, NY 14263, United States.
Cypate is an organic material with tumor treatment function, which has photothermal effect. Based on the characteristics of this material, this study adopted the coupling method to obtain FB-Cypate nano-microspheres, BDI-1-FB-Cypate albumin nano-microsphere diad and CPPs-BDI-1-FB-Cypate albumin nano-microsphere triad. Cypate and FB-Cypate materials were characterized by scanning TEM, particle size analyzer, and spectrophotometer. An injection-ureter introduction device was used to perfuse pediatric bladder cancer cells into the bladder cavity of nude mice, and different Cypate-type material solutions were perfused into the bladder cavity at the same time. Then, the anti-bladdertumor performance of different materials on tumor cells was compared. The test proves that the average particle diameter of FB-Cypate material is (102.3 ±8.6) nm, which can be used for near-infrared imaging, and the temperature rise is obvious under light conditions. In the test of inhibiting bladder cancer cells in children, the use of Cypate type materials can significantly inhibit the survival of bladder tumor cells, and it has less negative impact on physiological functions after surgery.
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外文
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第一作者：
第一作者机构：[1]Department of Urology, Panzhihua Central Hospital, Panzhihua City, 617067, Sichuan Province, China.
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推荐引用方式(GB/T 7714)：
Wang Ling,Tao Hong,Li Zhigang,et al.Preparation of Composite Cypate Nanoparticles and Its Application in the Treatment of Pediatric Bladder Tumors.[J].Journal of nanoscience and nanotechnology.2021,21(2):868-877.doi:10.1166/jnn.2021.18665.
APA：
Wang Ling,Tao Hong,Li Zhigang,Lei Yi,Bai Bing...&Irvine Darrell J.(2021).Preparation of Composite Cypate Nanoparticles and Its Application in the Treatment of Pediatric Bladder Tumors..Journal of nanoscience and nanotechnology,21,(2)
MLA：
Wang Ling,et al."Preparation of Composite Cypate Nanoparticles and Its Application in the Treatment of Pediatric Bladder Tumors.".Journal of nanoscience and nanotechnology 21..2(2021):868-877
