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The outstanding antitumor capacity of CD4+ T helper lymphocytes.

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机构： [1]Laboratory of Human Diseases and Immunotherapies, West China Hospital, Sichuan University, Chengdu 610041, China [2]State Key Laboratory of Biotherapy, Cancer Center, West China Hospital, Sichuan University and Collaborative Innovation Center for Biotherapy, Chengdu 610041, China. [3]School of Medicine, Stanford University, Stanford, CA 94304, USA. [4]MOE Laboratory of Biosystems Homeostasis and Protection and Innovation Center for Cell Signaling Network, Life Sciences Institute, Zhejiang University, Hangzhou 310058, China.

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关键词： CD4+ T cell subsets antitumor immunity tumor-infiltrating lymphocytes cancer immunotherapy tumor microenvironment CD4+ CAR-T cells

摘要：

Over the past decades, tumor-resident immune cells have been extensively studied to dissect their biological functions and clinical roles. Tumor-infiltrating CD8+ T cells, because of their cytotoxic and killing ability, have been under the spotlight for a long time, whereas CD4+ T cells are considered just a supporting actor in the field of cancer immunotherapy. Until recently, accumulating evidence has demonstrated the ability of CD4+ T cells in eradicating solid tumors, and their functions in mediating antitumor immunity have been investigated in various orientations. In this review, we highlight the pivotal role of CD4+ T cells in eliciting vigorous antitumor immune responses, summarize key signaling axes and molecular networks behind these antitumor functions, and also propose possible targets and promising strategies which might translate into more efficient immunotherapies against human cancers. Copyright © 2020 The Authors. Published by Elsevier B.V. All rights reserved.

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出版当年[2020]版中科院分区表Review为是的期刊

：

大类 | 2 区医学

小类 | 2 区生化与分子生物学 2 区生物物理 2 区肿瘤学

最新[2023]版

：

大类 | 1 区

医学

小类 | 2 区生化与分子生物学 2 区生物物理 2 区肿瘤学

第一作者：

第一作者机构： [1]Laboratory of Human Diseases and Immunotherapies, West China Hospital, Sichuan University, Chengdu 610041, China [2]State Key Laboratory of Biotherapy, Cancer Center, West China Hospital, Sichuan University and Collaborative Innovation Center for Biotherapy, Chengdu 610041, China.

通讯作者：

通讯机构： [1]Laboratory of Human Diseases and Immunotherapies, West China Hospital, Sichuan University, Chengdu 610041, China [*1]Laboratory of Human Diseases and Immunotherapies, West China Hospital, Sichuan University, Chengdu 610041, China.

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The outstanding antitumor capacity of CD4+ T helper lymphocytes.

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