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Expression of sFRP-4 and beta-catenin in human colorectal carcinoma.

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机构： [1]Department of Gastroenterological Surgery and Institute of Digestive System Surgery, West China Hospital, Sichuan University, Chengdu, Sichuan, China [2]Department of Radiation Oncology, Sir Charles Gairdner Hospital, Nedlands 6009, Australia [3]Department of Pathology, Shanxi Children’s Hospital, Shanxi, China [4]Department of Pathology, Royal Perth Hospital, Perth 6000, Australia [5]School of Surgery and Pathology, M507, University of Western Australia, 35 Stirling Highway, Nedlands 6009, Australia [6]School of Anatomy and Human Biology, The University of Western Australia, Nedlands 6009, Australia

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Alterations to the Wnt signalling pathway occur in the majority of colorectal cancers and result in abnormal accumulation of beta-catenin. The secreted frizzled related proteins (sFRPs) are antagonists that bind Wnt and inhibit signalling along this pathway. We investigated expression of the sFRP family member, sFRP-4, and beta-catenin in 1,044 human colorectal carcinomas using tissue microarrays and immunohistochemistry. Both proteins showed markedly increased expression levels in tumors compared to normal mucosa, but no significant associations with pathological features or with patient outcome. sFRP-4 was co-expressed with beta-catenin, p53, and COX-2, while the absence of beta-catenin expression was strongly associated with loss of expression of the MLH1 mismatch repair gene. In contrast to other sFRP family members, sFRP-4 expression appears to be upregulated in colorectal carcinoma.

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出版当年[2006]版：

大类 | 3 区医学

最新[2023]版：

大类 | 1 区

医学

小类 | 2 区肿瘤学

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第一作者机构： [1]Department of Gastroenterological Surgery and Institute of Digestive System Surgery, West China Hospital, Sichuan University, Chengdu, Sichuan, China

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