机构：[1]Laboratory of Molecular and Translational Medicine, West China Institute of Women and Children’s Health, West China Second University Hospital, Sichuan University, Chengdu 610041, China [2]Department of Forensic Biology,West China School of Preclinical and ForensicMedicine, Sichuan University, Chengdu 610041, China [3]Department of Neurosurgery, West China Hospital, Sichuan University, Chengdu 610041, China 四川大学华西医院[4]Department of Forensic Medicine, Kunming Medical University, Kunming 650031, China [5]Key Laboratory of Obstetric & Gynecologic and Pediatric Diseases and Birth Defects of Ministry of Education, Chengdu, Sichuan 610041, China
Several lines of evidence indicate that inflammatory processes play a key role in the happening and development of intracranial aneurysm (IA). Recently, polymorphisms in the TP53 gene were shown to be associated with inflammation and inflammatory disease. The aim of this study was to investigate the interactions of miR-34b/c and TP53 Arg72-Pro polymorphisms on the risk of IA in a Chinese population. A total of 590 individuals (including 164 patients with IA and 426 controls) were involved in this study. The polymorphisms (i.e., miR-34b/c rs4938723 and TP53 Arg72-Pro) were genotyped by polymerase chain reaction-restriction fragment length polymorphism assay and DNA sequencing. We found that the CC genotype of miR-34b/c rs4938723 was significantly associated with a decreased risk of IA compared with the TT genotype. Moreover, a significant gene interaction of the carriers with the combined genotypes of miR-34b/c rs4938723CC and TP53 Arg72Pro CG/CC/GG had a decreased risk of IA, compared with those carrying miR-34b/c rs4938723CT/TT+TP53 Arg72Pro GG/CG/CC combined genotypes. These findings suggest that the miR-34b/c rs4938723CC and TP53 Arg72-Pro polymorphisms may be involved in the susceptibility to IA.
基金：
the special research foundation
of doctoral priority to the development of field project (No.
20110181130013) and the Program for Changjiang Scholars
and Innovative Research Team in University (IRT 0935).
语种：
外文
PubmedID：
中科院(CAS)分区：
出版当年[2012]版：
大类|3 区医学
小类|4 区免疫学
最新[2023]版：
无
第一作者：
第一作者机构：[1]Laboratory of Molecular and Translational Medicine, West China Institute of Women and Children’s Health, West China Second University Hospital, Sichuan University, Chengdu 610041, China [2]Department of Forensic Biology,West China School of Preclinical and ForensicMedicine, Sichuan University, Chengdu 610041, China
通讯作者：
通讯机构：[1]Laboratory of Molecular and Translational Medicine, West China Institute of Women and Children’s Health, West China Second University Hospital, Sichuan University, Chengdu 610041, China [2]Department of Forensic Biology,West China School of Preclinical and ForensicMedicine, Sichuan University, Chengdu 610041, China [5]Key Laboratory of Obstetric & Gynecologic and Pediatric Diseases and Birth Defects of Ministry of Education, Chengdu, Sichuan 610041, China
推荐引用方式(GB/T 7714)：
Li Lijuan,Sima Xiutian,Bai Peng,et al.Interactions of miR-34b/c and TP53 polymorphisms on the risk of intracranial aneurysm.[J].Clinical & developmental immunology.2012,2012:567586.doi:10.1155/2012/567586.
APA：
Li Lijuan,Sima Xiutian,Bai Peng,Zhang Lushun,Sun Hong...&Gao Linbo.(2012).Interactions of miR-34b/c and TP53 polymorphisms on the risk of intracranial aneurysm..Clinical & developmental immunology,2012,
MLA：
Li Lijuan,et al."Interactions of miR-34b/c and TP53 polymorphisms on the risk of intracranial aneurysm.".Clinical & developmental immunology 2012.(2012):567586
